The Efficacy of Danofloxacin in the Therapy of Acute Bacterial Pneumonia in Housed Beef Cattle

Abstract

Danofloxacin* is an antimicrobial of the fluoroquinolone class, and has shown potent in vitro activity against the major bacterial pathogens involved in respiratory disease, Pasteurella haemolytica and Pasteurella multocida(1). Pharmacokinetic studies with danofloxacin in cattle have demonstrated an attractive profile. The drug is rapidly absorbed and distributed to respiratory tract tissues and secretions following intramuscular or subcutaneous administration ( 2, 3) . This paper summarizes the results of 11 studies in beef cattle conducted in Europe. The efficacy of danofloxacin against naturally occurring outbreaks of acute pneumonia was evaluated in comparison with oxytetracycline and trimethoprim/sulpha.
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