The efficacy of cyclosporine A in cats with presumed atopic dermatitis: A double blind, randomised prednisolone-controlled study

Wisselink, M. A.; Willemse, Ton

doi:10.1016/j.tvjl.2007.11.018

Cited by 50 publications

(98 citation statements)

References 13 publications

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“…The use of ciclosporin is gaining acceptance for treatment of feline allergic dermatitis, as several studies and anecdotal reports have demonstrated efficacy and apparent safety 3,4 . The true safety of this drug is of concern, as only limited data are available that specifically address the adverse effects of ciclosporin in cats 5–7 …”

Section: Introductionmentioning

confidence: 99%

Adverse events in 50 cats with allergic dermatitis receiving ciclosporin

Heinrich¹,

McKeever²,

Eisenschenk³

2011

Veterinary Dermatology

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Ciclosporin is an immunosuppressive drug that has been used to treat allergies and other immune-mediated diseases in cats, dogs and humans. Information about the adverse effects of ciclosporin in cats has been limited to smaller studies and case reports. Adverse effects in dogs are mainly gastrointestinal in nature, but humans can also experience hypertension and altered renal function. The aim of this retrospective case series study was to document the occurrence and clinical appearance of adverse events in cats receiving ciclosporin to treat allergic skin disease. The medical records of 50 cats with allergic dermatitis treated with oral ciclosporin (1.9-7.3 mg/kg/day) were reviewed. Adverse events occurred in 66% (33 cats). Adverse events likely to be associated with ciclosporin included the following: vomiting or diarrhoea within 1-8 weeks of receiving ciclosporin (24%), weight loss (16%), anorexia and subsequent hepatic lipidosis (2%) and gingival hyperplasia (2%). Other adverse events less likely to be associated with ciclosporin therapy included the following: weight gain (14%), dental tartar and gingivitis (10%), otitis (4%), chronic diarrhoea (4%), inflammatory bowel disease with indolent gastrointestinal lymphoma (2%), urinary tract infection (2%), cataract (2%), elevated liver enzymes (2%), hyperthyroidism and renal failure (2%) and transient inappropriate urination (2%). Some cats experienced multiple adverse events. Case-control studies are needed to prove cause and effect of ciclosporin with regard to these adverse events.

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Section: Introductionmentioning

confidence: 99%

Adverse events in 50 cats with allergic dermatitis receiving ciclosporin

Heinrich¹,

McKeever²,

Eisenschenk³

2011

Veterinary Dermatology

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“…In our study, only 56.3% of the cats responded to prednisone, while 83.7% responded to prednisolone. A previous report indicated that only 36% of cats with AD had a satisfactory response to prednisolone 49) .…”

Section: Discussionmentioning

confidence: 97%

“…FAD is now a widely accepted clinical and therapeutic reality 3,4,6,14,[26][27][28][29]33,38,46,48,49) .…”

Section: Introductionmentioning

confidence: 99%

Feline Atopic Dermatitis: A Retrospective Study of 194 Cases (1988^|^ndash;2003)

Scott

Miller

2013

Jpn J Vet Dermatol

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Atopic dermatitis was diagnosed in 13.8% of the feline dermatology cases and 0.9% of all cats examined over a 15-year period. No age or sex predilection was found, but Abyssinians, Himalayans, and Persians were over-represented. Clinical signs were nonseasonal in 62.4% of the cats. Cutaneous reaction patterns -in descending order of prevalence -included initially lesionless symmetrical pruritus (especially face, ears, and neck), self-induced hair loss (especially abdomen, back, and legs), miliary dermatitis (especially back and neck), and eosinophilic granuloma complex (especially lips, abdomen, and medial thighs). Multiple cutaneous reaction patterns were present in 36.2% of the cats. Secondary bacterial or yeast infections occurred in 18.6% and 6.6%, respectively, of the cats. Only 4.5% of the cats had concurrent food allergy, and none had flea-bite hypersensitivity. Medical management with systemic glucocorticoids, antihistamines, omega-6/ omega-3 fatty acids, allergen-specific immunotherapy, or combinations of these provided satisfactory control of clinical signs for the majority of affected cats.

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“…In general practice, it accounts for approximately 2% of skin diseases presented to a primary care veterinarian. 74,106 If the cat responds to cyclosporine therapy, the cost of immunotherapy versus cyclosporine therapy should be considered, insofar as cyclosporine therapy is inexpensive in small patients and may be less expensive for long-term management. 95,96 Briefly, the difference is the administration of allergens in increasing amounts until a maintenance dose is reached over approximately 1 month (traditional) versus several days (rush).…”

Section: Dermatophytosismentioning

confidence: 99%

Dermatology

Moriello¹

2012

The Cat

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The efficacy of cyclosporine A in cats with presumed atopic dermatitis: A double blind, randomised prednisolone-controlled study

Cited by 50 publications

References 13 publications

Adverse events in 50 cats with allergic dermatitis receiving ciclosporin

Adverse events in 50 cats with allergic dermatitis receiving ciclosporin

Feline Atopic Dermatitis: A Retrospective Study of 194 Cases (1988^|^ndash;2003)

Dermatology

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