The efficacy of corticosteroid therapy in inflammatory bowel disease: analysis of a 5‐year UK inception cohort

Abstract

SUMMARY BackgroundCorticosteroids remain the mainstay of first-line therapy in active inflammatory bowel disease.

Ulcerative colitis in a Southern European country: A national perspective

“…Although different definitions and time frames were applied, this percentage was similar to what was found by others, 19 where 38% of patients were considered corticodependent or needing alternative treatments, namely, surgery.…”

Current use of immunosuppressive agents in inflammatory bowel disease patients in East China

“…Although glucocorticoids are effective in the induction of remission for IBD, more than 20% of patients may be steroid-refractory or become steroid-dependent [15][16][17] . Meta-analyses showed that glucocorticoids are not effective for medical maintenance.…”

Predictive factors of response to intravenous ciclosporin in severe ulcerative colitis: the development of a novel prediction formula

“…1,2 Patients with severe symptoms are treated with intravenous corticosteroids as a first-line therapy with a response rate of approximately 60%. [3][4][5][6] Previous studies have determined some predictive indices of response to intravenous corticosteroids in patients with UC: Oxford Index consisting of stool frequency and C-reactive protein on the third day after corticosteroid administration, Sweden Index (fulminant colitis index) consisting of stool frequency and C-reactive protein on the third day after corticosteroid administration, and Ho Index consisting of serum albumin on the first day, transverse colon diameter on plain X-ray, and average stool frequency on the first to third days after corticosteroid administration (Table S1). [7][8][9] In other reports, the presence of severe endoscopic lesions and long duration of present flare-up were also shown to be useful for predicting response to intravenous corticosteroids.…”