2003
DOI: 10.2165/00128071-200304070-00006
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The Efficacy of Calcipotriol + Acitretin Combination Therapy for Psoriasis

Abstract: Our results showed that calcipotriol might enhance the clinical outcome of systemic acitretin therapy. More large, well-controlled, long-term studies need to be conducted to determine whether there is indeed a beneficial effect of the addition of calcipotriol to acitretin treatment and whether this effect is maintained over long-term periods.

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Cited by 43 publications
(18 citation statements)
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“…35 In one study the number of patients clear or almost clear was increased from 41% to 67% by the addition of calcipotriol 36 and the number of patients with complete clearance increased in the other from 15% to 40% after 12 weeks. 37 …”
Section: Acitretin and Calcipotriol Ointmentmentioning
confidence: 99%
“…35 In one study the number of patients clear or almost clear was increased from 41% to 67% by the addition of calcipotriol 36 and the number of patients with complete clearance increased in the other from 15% to 40% after 12 weeks. 37 …”
Section: Acitretin and Calcipotriol Ointmentmentioning
confidence: 99%
“…[109][110][111]116,117 Three trials considered the drug as a monotherapy compared with placebo 109,110 or PUVA 111 and the other two trials investigated the combination of acitretin with calcipotriol compared with acitretin alone. 116,117 There are additional trials of etretinate versus placebo; 66 however, in this review we did not assume that etretinate equated with acitretin and these trials have not been included.…”
Section: Trials Involving Acitretinmentioning
confidence: 99%
“…116, 117 One trial found that clearance was achieved significantly more often with combination therapy than with acitretin and placebo, 116 but the other trial did not. 117 Overall, the few data available indicate that acitretin has some efficacy in the treatment of psoriasis and this might be enhanced when use in combination with calcipotriol.…”
Section: Trials Involving Acitretinmentioning
confidence: 99%
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“…Its effectiveness in monotherapy is low and it is usually administered in combination with other topical or systemic treatments in order to obtain faster whitening with fewer secondary effects. It has been used in combination with vitamin D derivates applied topically (3,4) with psoralen ultraviolet A therapy (PUVA) and UVB phototherapy, and with methotrexate and cyclosporine (5).…”
Section: Sirmentioning
confidence: 99%