The efficacy of anti-viral therapy and serotherapy of tick-borne encephalitis in children

Скрипченко, Н В; Ivanova, G. P.; Skripchenko, E.Yu.; Пульман, Н. Ф.; Мурина, Е. А.

doi:10.17116/jnevro201911907240

Cited by 3 publications

(1 citation statement)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Ribavirin has also been used to treat patients infected with Lassa fever virus or Crimean-Congo hemorrhagic fever virus ( Ascioglu et al, 2011 ; Johnson et al, 2018 ; Cheng et al, 2022 ). In particular, ribavirin had antiviral efficacy in children with tick-borne encephalitis ( Skripchenko et al, 2019 ). Although ribavirin is regarded as a safe antiviral drug, the effectiveness of ribavirin for the viruses remains to be validated and the precise mechanisms of ribavirin action are still not completely understood.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of tick-borne encephalitis virus in cell cultures by ribavirin

Tang¹,

Tang²,

Peng³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

Tick-borne encephalitis virus (TBEV) belonging to arboviruses is a major member of zoonotic pathogens. TBEV infection causes severe human encephalitis without specific antiviral drugs. Due to its use of antiviral drug against a wide range of viruses, we investigated antiviral effect of ribavirin against TBEV in susceptible human cell lines A549 and SH-SY5Y. Ribavirin displayed minor cytotoxicity on multiple cell lines. Ribavirin obviously impaired TBEV replication and protected the infected cells from cytopathic effect. Importantly, ribavirin markedly inhibited TBEV propagation, as evidenced by impairment of TBEV production and viral RNA replication. Treatment with ribavirin (co-treatment and post-treatment) led to a dose-dependent reduction in TBEV titers as well as the viral RNA levels. Antiviral protein myxovirus resistance A mRNA expression was significantly up-regulated and signal transducer and activator of transcription 3 was activated in TBEV-infected A549 cells upon the ribavirin treatment. Induction of inflammatory cytokine tumor necrosis factor alpha by TBEV was decreased in A549 cells with the treatment of ribavirin, whereas interleukin 1 beta release appeared to be unaffected. These results suggest that ribavirin might represent a promising safe and effective antiviral drug against TBEV.

show abstract

Section: Introductionmentioning

confidence: 99%

Inhibition of tick-borne encephalitis virus in cell cultures by ribavirin

Tang¹,

Tang²,

Peng³

et al. 2023

Front. Microbiol.

View full text Add to dashboard Cite

show abstract

Structural epilepsy or herpes simplex encephalitis relapse: diagnostic problems

Gorelik¹,

Скрипченко²,

Вильниц³

et al. 2022

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Hopantomide in pediatric neurological practice: outlooks

Пылаева¹

2021

Rus. ž. det. nevrol.

View full text Add to dashboard Cite

Hopantomide® is a drug containing calcium salt of hopantenic acid. The drug is registered and produced in Russia (Usolye-Siberian Chemical Pharmaceutical Factory) with the use of own raw materials and goes through a full production cycle, which guarantees quality control at every stage. Hopantomide belongs to nootropics and has neurometabolic, neuroprotective, and neurotrophic properties, as well as anticonvulsant action. According to the package insert and results of the studies evaluating the efficacy of hopantenic acid, Hopantomide has a number of positive therapeutic effects. It increases brain resistance to hypoxia and toxic substances, stimulates anabolic processes in neurons, improves mental and physical performance, combines moderate sedative action with mild stimulating effect, reduces motor excitability with simultaneous regulation of behavior, improves the metabolism of gamma-aminobutyric acid and normalizes its level in individuals with chronic alcohol intoxication and after alcohol withdrawal, has anxiolytic and thymoleptic properties, inhibits the abnormal bladder reflex and detrusor tone. This ensures high efficacy of Hopantomide in the treatment of various nervous diseases in different age groups. In our opinion, the combination of various positive effects of just one drug can significantly reduce the pharmacological burden. In this review, we discuss well-known and potential mechanisms of action, indications for its use with a focus on Hopantomide benefits in pediatric neurological practice, and studies evaluating the efficacy of hopantenic acid in clinical practice. Particular attention is paid to the possibilities of its use in children, including those with attention deficit hyperactivity disorder and developmental delay, as well as the part of combination therapy for epilepsy together with antiepileptic drugs.Drugs containing hopantenic acid are well tolerated by patients, including children who receive it for a long time.

show abstract

The efficacy of anti-viral therapy and serotherapy of tick-borne encephalitis in children

Cited by 3 publications

References 9 publications

Inhibition of tick-borne encephalitis virus in cell cultures by ribavirin

Inhibition of tick-borne encephalitis virus in cell cultures by ribavirin

Structural epilepsy or herpes simplex encephalitis relapse: diagnostic problems

Hopantomide in pediatric neurological practice: outlooks

Contact Info

Product

Resources

About