The Efficacy of Ankaferd Blood Stopper in Heparin‐Induced Hemostatic Abnormality in a Rat Epistaxis Model

İynen, İsmail; Söğüt, Özgür; Köse, Rüştü

doi:10.1177/0194599811415594

Cited by 12 publications

(13 citation statements)

References 21 publications

(51 reference statements)

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“…In the present study, topically administered ABS conferred a hemostatic effect in a rabbit epistaxis model. Iynen et al [22] reported that ABS solution reduced nasal bleeding in normal rats to 1.57 vs. 2.86 min in heparin-pretreated rats. Bilgili et al [8] used an ABS tampon in a porcine model to treat skin bleeding following laceration and saphenous vein and artery hemorrhage.…”

Section: Discussionmentioning

confidence: 99%

“…Cipil et al [20] reported that application of topical ABS to an amputated leg shortened bleeding time in both untreated and warfarin-treated rats, and Iynen et al [22] reported that ABS decreased bleeding volume. Similarly, in our study, topical application of ABS in a rabbit epistaxis model decreased the amount of bleeding compared with the control group.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

Yurttaş

Şereflican

Terzi

et al. 2015

Eur Arch Otorhinolaryngol

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The aim of this study was to evaluate the histopathological impact, effectiveness, and safety of two hemostatic agents, Ankaferd Blood Stopper (ABS) and microporous polysaccharide hemospheres (MPH), in an experimental rabbit epistaxis model. Rabbits were randomly assigned, using a computerized random number generator, to the following three groups of six animals: group 1 (control, irrigated with saline); group 2 (ABS-treated); and group 3 (MPH-treated). In all groups, a standardized rabbit epistaxis model was used. Hemostasis time and extent of nasal bleeding were measured to compare the hemostatic effect of ABS and MPH among groups. Septums were removed for histopathological analysis, 7 days after the procedure. ABS reduced hemostasis time to 104.2 s and amount of bleeding to 20.5 mg. MPH reduced hemostasis time to 71.7 s and amount of bleeding to 11.5 mg. Mean bleeding time in wounds administered ABS and MPH was significantly shorter compared with wounds administered isotonic saline solution (p = 0.004). ABS and MPH application decreased bleeding significantly compared with the control group (p = 0.004). Bleeding time and amount in the MPH group was significantly reduced compared with the ABS group (p = 0.013 and p = 0.004, respectively). There was no significant difference in the histopathological evaluation results between the ABS, MPH, and control groups. Our data indicate that both ABS and MPH represent safe, effective, and fast-acting hemostatic agents in the management of epistaxis. MPH was more effective than ABS in terms of hemostasis time and amount of bleeding.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

Yurttaş

Şereflican

Terzi

et al. 2015

Eur Arch Otorhinolaryngol

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show abstract

“…is to prevent or manage for arterial and venous thrombosis (7,16). The use of such anticoagulant agents alters the coagulation cascade in the body (1,16). One of the most important factors in coagulation is the vitamin K. Warfarin is one of the most common used vitamin K antagonist agent and it is quickly adsorbed and well tolerated by oral route.…”

Section: Discussionmentioning

confidence: 99%

“…Ankaferd Blood Stopper® ABS (Ankaferd Health Products Ltd., İstanbul, Turkey) products are available as a liquid (solution), spray or in a dressing (tampon) forms that contain a standardized mixture of 5 medicinal plant extracts. The liquid form of ABS was used in the study and it includes active ingredients as follows: 0.16 mg of dried leaf of Vitis vinifera, 0.12 mg of dried root of Urtica dioica, 0.14 mg of dried leaf of Alpinia officinarum, 0.18 mg of dried leaf of Glycyrrhiza glabra, and 0.10 mg of dried leaf of Thymus vulgaris (1).…”

Section: Methodsmentioning

confidence: 99%

“…Bleeding is a common challenging problem especially in patients who take an anticoagulant or antiaggregant treatment (i.e., patients with clotting disorders). Severe bleeding can be a life-threatening condition and should be managed effectively in a variety of ways including mechanic sponge pressing on the bleeding area; vessel ligation; applying chemical or electro-cauterization and cryotherapy; using topical haemostatic or vasoconstrictor agents and etc (1)(2)(3)(4). Various haemostatic agents have been investigated for their role in haemostasis for decades (2,4).…”

Section: Introductionmentioning

confidence: 99%

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The Hemostatic Effect of Ankaferd Blood Stopper in Rat Bleeding Models with Antithrombotic Drug Therapy: An Experimental <i>In Vivo</i> Study

Akbulut¹,

Akar²,

Eren³

et al. 2018

meandros

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Amaç: Ankaferd kanama durdurucu, eksternal hemorajinin tedavisinde hemostatik bir ajan olarak kullanılan beş tıbbi bitki özütünün bir karışımıdır. Bu çalışmanın amacı, Ankaferd kanama durdurucusunun (ABS) antitrombotik ilaç almış in vivo modellerde diş çekimi sonrası kanama üzerine hemostatik etkilerini değerlendirmektir. Öz Objective: Ankaferd blood stopper is a mixture of five medicinal plant extracts used as a hemostatic agent for management of external hemorrhage. The aim of this study was to evaluate the hemostatic effects of Ankaferd blood stopper (ABS) on bleeding after tooth extraction in vivo models with taking antithrombotic drug. Materials and Methods: Forty-eight male Albino Wistar rats were divided into six groups of 8 animals each. Maxillary right first molar tooth of the rats were extracted under general anesthesia. 2 mL saline solutions were applied topically to Control group (group 1), Warfarin group (group 3) and Heparin group (group 5) on the sockets immediately after extraction. Two ml ABS's were applied topically to Ankaferd group (group 2), Warfarin-Ankaferd group (group 4) and Heparin-Ankaferd group (group 6) likewise. The bleeding time and the amount of bleeding were compared among 6 groups just following the tooth extraction. The collected data results were analysed statistically by the ANOVA followed by Tukey test for pair-wise comparisons. Results: The bleeding time was longer in Warfarin and Heparin group than the Control group (p<0.05), Ankaferd, Warfarin-Ankaferd and Heparin-Ankaferd groups (p>0.05). Similiarly, the amount of bleeding of Warfarin group was significantly higher than those of the Control and Warfarin-Ankaferd group (p<0.05). The amount of bleeding were lower in Control, Heparin and Heparin-Ankaferd groups but the differences were not statistically significant (p>0.05). Conclusion: Topically administered ABS is less effective on bleeding control of Warfarin-induced bleeding model than Heparin-induced bleeding model in wistar rats. Resulting small difference in between warfarin and heparin should be investigated in future studies.

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Comparison of the Ankaferd Blood Stopper Tampon and the Merocel Nasal Tampon after Septoplasty Surgery

2022

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The Efficacy of Ankaferd Blood Stopper in Heparin‐Induced Hemostatic Abnormality in a Rat Epistaxis Model

Abstract: ABS irrigation was more effective than saline irrigation for treating anterior epistaxis hemostasis in animals using a compressive dressing with or without heparin pretreatment.

Cited by 12 publications

References 21 publications

Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

Comparison of microporous polysaccharide hemospheres and Ankaferd Blood Stopper in a rabbit epistaxis model

The Hemostatic Effect of Ankaferd Blood Stopper in Rat Bleeding Models with Antithrombotic Drug Therapy: An Experimental <i>In Vivo</i> Study

Comparison of the Ankaferd Blood Stopper Tampon and the Merocel Nasal Tampon after Septoplasty Surgery

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