The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta‐analysis

Ali, Shereen; Wahbi, Walaa

doi:10.1111/odi.12631

Cited by 47 publications

(39 citation statements)

References 23 publications

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“…The pooled data of the three studies showed superiority of aloe vera in reducing pain in OSF patients especially at the end of the 1st and 2nd months, demonstrating good efficacy and quick action of aloe vera in reducing pain as compared to other treatment modalities. The outcome of this review corroborates previous systematic reviews which reported aloe vera to be effective in reducing mucosal pain in patients with various oral mucosal diseases including oral lichen planus, recurrent aphthous stomatitis, burning mouth syndrome, and radiation‐induced mucositis . Overall, the efficacy of aloe vera in alleviating signs and symptoms of OSF can be attributed to its analgesic and anti‐inflammatory properties .…”

Section: Discussionsupporting

confidence: 85%

“…Recently, aloe vera has been introduced as a natural herbal alternative for the management of OSF . Aloe vera is an ancient plant that has several pharmacological benefits and has long been used as a remedy for numerous medical conditions without any reported side effects . Primarily, the medical benefits of aloe vera are attributed to its analgesic, anti‐inflammatory, immune‐modulatory, antioxidant, anti‐neoplastic, and wound‐healing properties .…”

Section: Introductionmentioning

confidence: 99%

“…[15][16][17] Aloe vera is an ancient plant that has several pharmacological benefits and has long been used as a remedy for numerous medical conditions without any reported side effects. [18][19][20][21] Primarily, the medical benefits of aloe vera are attributed to its analgesic, anti-inflammatory, immune-modulatory, antioxidant, anti-neoplastic, and wound-healing properties. 18,22 A number of clinical trials have assessed the efficacy of aloe vera in the management of OSF patients.…”

mentioning

confidence: 99%

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Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta‐analysis

Al‐Maweri

Ashraf

Lingam

et al. 2018

J Oral Pathology Medicine

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The management of oral submucous fibrosis (OSF) is quite challenging, and as yet, no effective therapy is available for its management. The present systematic review and meta‐analysis sought to assess the effectiveness of aloe vera in alleviating pain and clinical signs of OSF. A comprehensive search in PubMed/Medline, Scopus, and Web of Science databases was conducted to identify the relevant randomized clinical trials. RevMan 5.3 software was used for data analysis. Six randomized controlled trials fulfilled the inclusion criteria. The results of meta‐analysis showed statistically significant differences between aloe vera and control groups in alleviating pain/burning sensation at the end of the first and second month, in favor of aloe vera, but no significant differences were found at the end of the third month. With regard to objective clinical outcomes, no statistically significant differences were found between the groups. Aloe vera has a promising effect in reducing pain/burning sensation and clinical improvement in patients with OSF. However, owing to the marked heterogeneity of the included studies, conducting well‐designed trials with long follow‐up periods, standardized outcome measures and adequate sample sizes are warranted.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta‐analysis

Al‐Maweri

Ashraf

Lingam

et al. 2018

J Oral Pathology Medicine

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“…[5] The main inconvenience of these treatments is represented by the side effects including insomnia, nervousness, fluid retention, electrolyte imbalance, hyperglycemia, osteoporosis, nephrotoxicity, gingival hyperplasia, nausea, and headache. [6] International Dental & Medical Journal of Advanced Research • Vol. 4 • 2018 Due to these side effects, the possibility of prolonged treatment with steroids, and the fact that the disease process could still last for years, an alternative therapy is desirable.…”

Section: Introductionmentioning

confidence: 99%

“…Topical treatment is a good choice because of its less harmful side effects. [6] Studies have demonstrated that AV has an important therapeutic uses in the management of oral lesions such as oral submucous fibrosis, radiation-induced mucositis, burning mouth syndrome, xerostomia, and recurrent aphthous ulcers. [8,9] The aim of the study is to evaluate the efficacy of AV gel in the treatment of OLP compared with placebo.…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Aloe vera Gel in Treatment of Oral Lichen Planus

Ahmed¹,

Gadalla²,

Elmeadawy³

et al. 2018

IDJAR

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Background: Aloe vera (AV) gels with different concentrations are available in the market. In this study, we evaluate the efficacy of AV gel with two different concentrations in the treatment of oral lichen planus (OLP) compared with placebo. Materials and Methods: A total of 21 females suffering from the clinical signs and symptoms of OLP were grouped into Group (I) patients receiving AV gel divided into two subgroups, subgroup (A) received AV 70% concentration (7 patients) and subgroup)B) received AV 90% concentration (7 patients) and Group (II) control group received placebo (7 patients).Results: There was no statistically significant difference between ulcer sizes at all points of follow-up in Egyptian and Australian AV compared to placebo. The degree of change was higher in Egyptian than Australian AV regarding size, erythema, reticulation, and total area of lesion. However, there was no statistically significant difference between two types of treatment as regards all measured parameters (P > 0.05). Conclusions: AV gel whether Egyptian or Australian is statistically significantly more effective than placebo in inducing marked improvement clinically of OLP. Therefore, AV gel can be considered a safe alternative treatment for patients with OLP. Clinical Significance: AV gel can be considered a safe alternative treatment for patients with OLP.

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Interventions for treating oral lichen planus: corticosteroid therapies

Lodi

Manfredi

Mercadante

et al. 2020

Cochrane Database of Systematic Reviews

100

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Background Oral lichen planus (OLP) is a relatively common chronic T cell-mediated disease, which can cause significant pain, particularly in its erosive or ulcerative forms. As pain is the indication for treatment of OLP, pain resolution is the primary outcome for this review. This review is an update of a version last published in 2011, but focuses on the evidence for corticosteroid treatment only. A second review considering non-corticosteroid treatments is in progress. Objectives To assess the e ects and safety of corticosteroids, in any formulation, for treating people with symptoms of oral lichen planus. Search methods Cochrane Oral Health's Information Specialist searched the following databases to 25 February 2019: Cochrane Oral Health's Trials Register, CENTRAL (2019, Issue 1), MEDLINE Ovid, and Embase Ovid. ClinicalTrials.gov and the World Health Organization International Clinical Trials Registry Platform were searched for ongoing trials. There were no restrictions on language or date of publication. Selection criteria We considered randomised controlled clinical trials (RCTs) of any local or systemic corticosteroid treatment compared with a placebo, a calcineurin inhibitor, another corticosteroid, any other local or systemic (or both) drug, or the same corticosteroid plus an adjunctive treatment. Data collection and analysis Three review authors independently scanned the titles and abstracts of all reports identified, and assessed risk of bias using the Cochrane tool and extracted data from included studies. For dichotomous outcomes, we expressed the estimates of e ects of an intervention as risk ratios (RR), with 95% confidence intervals (CI). For continuous outcomes, we used mean di erences (MD) and 95% CI. The statistical unit of analysis was the participant. We conducted meta-analyses only with studies of similar comparisons reporting the same outcome measures. We assessed the overall certainty of the evidence using GRADE. Main results We included 35 studies (1474 participants) in this review. We assessed seven studies at low risk of bias overall, 11 at unclear and the remaining 17 studies at high risk of bias. We present results for our main outcomes, pain and clinical resolution measured at the end of Interventions for treating oral lichen planus: corticosteroid therapies (Review)

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The efficacy of aloe vera in management of oral lichen planus: a systematic review and meta‐analysis

Cited by 47 publications

References 23 publications

Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta‐analysis

Aloe vera in treatment of oral submucous fibrosis: A systematic review and meta‐analysis

The Efficacy of Aloe vera Gel in Treatment of Oral Lichen Planus

Interventions for treating oral lichen planus: corticosteroid therapies

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