The efficacy of 99mTc-HIG for sentinel lymph node mapping in breast cancer patients

Gençoğlu, Esra Arzu; Yalcn, Hulya; Yağmurdur, Mahmut Can; Özen, Aynur; Başaran, Ö.; Karakayal, Feza; Ekici, Yahya; Karakayal, Hamdi; Aktaş, Ayşe

doi:10.1097/01.mnm.0000173300.86891.43

Cited by 4 publications

(2 citation statements)

References 30 publications

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“…It provides significant information about the lymphatic pathways and helps in shortening the duration of the SLN biopsy. [35][36][37][38][39][40] In our sample, preoperative bilateral SLN detection was successful in 100% of the patients where a clear focal accumulation of radioactivity was visible in both axillary regions. In the majority of patients, the mean number of SLN detected was 2 per patient and no extra-axillary radioactive accumulations were observed.…”

Section: Discussionmentioning

confidence: 86%

The Influence of Subfascial Transaxillary Breast Augmentation in Axillary Lymphatic Drainage Patterns and Sentinel Lymph Node Detection

Munhoz

Aldrighi

Ono

et al. 2007

Annals of Plastic Surgery

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Section: Discussionmentioning

confidence: 86%

The Influence of Subfascial Transaxillary Breast Augmentation in Axillary Lymphatic Drainage Patterns and Sentinel Lymph Node Detection

Munhoz

Aldrighi

Ono

et al. 2007

Annals of Plastic Surgery

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“…Unfortunately, these radiopharmaceuticals are not always available in Asia. Other proposed radiopharmaceuticals include Tc-99m-labeled dextran, Tc-99m hydroxy ethyl starch, Tc-99m human serum albumin (HSA), Tc-99m stannous phytate, and Tc-99m human polyclonal immunoglobulin G (HIG) [2,3]. However, commonly available and inexpensive Tc-99m diphosphonate has never been evaluated for sentinel lymph node mapping despite Boxen′s suggestion.…”

Section: Introductionmentioning

confidence: 99%

Tc-99m Diphosphonate as a Potential Radiotracer to Detect Sentinel Lymph Nodes in Patients with Breast Cancer

Yang

Lim

Song

2010

Nucl Med Mol Imaging

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Purpose To evaluate the potential of Tc-99m diphosphonate as a tracer for sentinel lymph node biopsy in breast cancer. Methods Lymphoscintigraphs of 35 patients (50.9 ± 10.2 years) with breast cancer were acquired after administering a subareolar intradermal injection of Tc-99m diphosphonate 18 h before surgery. Static images were taken within 15 min (early phase) and 15 h after injection (delayed phase). The lymphoscintigraphic identification rate was defined as the percentage of subjects studied with visible foci at axillae. Sentinel lymph node biopsies were performed using a gamma probe and by blue dye injection. Any node that was radioactive or stained with blue dye was labeled as a sentinel lymph node. Lymph nodes without radioactivity or blue dye staining were defined as nonsentinel lymph nodes. The intraoperative identification rate was defined as the percentage of patients with a radioactive sentinel lymph node. Percentages of lymphoid cells expressing S-100, CD83, and CD1a were compared.Results The lymphoscintigraphic identification rate was 94.3% (33/35) during the early phase and 96.9% (31/32) during the delayed phase, whereas the intraoperative identification rate was 94.3% (33/35). The mean percentages of lymphoid cells that stained positively for S-100 or CD83 were lower in sentinel lymph nodes than in nonsentinel lymph nodes (1.5% vs. 9.0% for S-100, and 4.5% vs. 9.3% for CD83, respectively, p=0.0286). The mean percentages of lymphoid cells in sentinel lymph nodes and non-sentinel lymph nodes expressing CD1a were 3.3% and 7.0%, respectively (p=ns). Conclusions Tc-99m diphosphonate can reliably detect regional lymph nodes in breast cancer.

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Use of 99mTc labelled human immunoglobulin G for sentinel node imaging

Bury¹

2005

Nuclear Medicine Communications

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The efficacy of 99mTc-HIG for sentinel lymph node mapping in breast cancer patients

Abstract: We conclude that Tc-HIG may be a suitable agent for SLN detection by lymphoscintigraphy and intraoperative gamma probe application in early-stage breast cancer patients.

Cited by 4 publications

References 30 publications

The Influence of Subfascial Transaxillary Breast Augmentation in Axillary Lymphatic Drainage Patterns and Sentinel Lymph Node Detection

The Influence of Subfascial Transaxillary Breast Augmentation in Axillary Lymphatic Drainage Patterns and Sentinel Lymph Node Detection

Tc-99m Diphosphonate as a Potential Radiotracer to Detect Sentinel Lymph Nodes in Patients with Breast Cancer

Use of 99mTc labelled human immunoglobulin G for sentinel node imaging

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