The efficacy of 12 weeks non-surgical treatment for patients not eligible for total knee replacement: a randomized controlled trial with 1-year follow-up

Abstract

ClinicalTrials.gov (NCT01535001).

One year effectiveness of neuromuscular exercise compared with instruction in analgesic use on knee function in patients with early knee osteoarthritis: the EXERPHARMA randomized trial

“…Our finding of sustained improvement in PROs during a year is in line with two recent randomized trials investigating the longterm effects of 12 weeks NEMEX 5,14 . Both studies observed continued within-group improvements at 12 or 24 months followup for the NEMEX groups.…”

“…One-year positive effects of non-surgical interventions including NEMEX have been reported in randomized trials of patients with moderate to severe knee OA 4,5 (within-group Cohen's d ranging between 0.35 and 0.60) or in conjunction with total knee replacement 4,6,7 (within-group Cohen's d ranging between 0.47 and 0.87). One-year improvements have also been shown when NEMEX is delivered large-scale in clinical practice 8 .…”

What interventions can improve quality of life or psychosocial factors of individuals with knee osteoarthritis? A systematic review with meta-analysis of primary outcomes from randomised controlled trials

“…Specifically, exercise therapy was superior in improving knee-related QoL compared with self-management booklet (SMD=0.59, CI 0.16 to 1.02) 53. Exercise therapy was as effective as no treatment (SMD=0.21, CI −0.30 to 0.71) 54…”

Translating Comprehensive Conservative Care for Chronic Knee Pain Into a Digital Care Pathway: 12-Week and 6-Month Outcomes for the Hinge Health Program

“…Such programs have shown clinically relevant reductions in pain that last up to 5 years [10,11] and medical cost savings due to a reduced need for injections, drugs, and surgery [8], with one intervention for CKP due to knee OA showing a 75% (8/41 had knee replacement in control vs 2/42 in treatment) reduction in rate of total knee replacements [12]. Comprehensive care for CKP due to knee OA is also more effective at reducing pain in the long-term compared with physical therapy only [13-16]. However, chronic pain programs are rare for CKP, and over 80% of individuals with CKP due to knee OA receive suboptimal conservative care [17].…”