The efficacy, mode of action and safety of non-steroidal non-antimicrobial growth promoters

Sn, Dixon

doi:10.1007/bf02228596

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Conversely, treatment of castrated males with androgen increased plasma growth hormone concentrations (Davis et al, 1977). Treatment with oestrogens, such as oestradiol-l7fi, diethylstilboestrol, hexoestrol and zeranol, also increased plasma somatotropin concentrations in sheep, cattle, steers, and in man (Wiedemann et al, 1976;Dixon, 1983;Galbraith, 1983;Buttery & Sinnett-Smith, 1984;Davis et al, 1984;Moll et al, 1986).…”

Section: Discussionmentioning

confidence: 99%

Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone

Witkamp

Nijmeijer

Duin

et al. 1989

Vet Pharm & Therapeutics

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Daily subcutaneous BST injection in lactating cows, bulls and castrated male dwarf goats did not induce significant changes in the pharmacokinetic parameters of antipyrine (AP) and sulphadimidine (SDD). Similarly, no changes were obtained after injection of slow-release BST formulations in lactating cows and non-lactating female goats. In contrast to androgenic hormones, both zeranol and proligestone had no effect upon the disposition of AP and SDD, although both synthetic hormones did induce enhanced plasma somatotropin concentrations. In goats, metabolic effects induced by zeranol and BST included significant reductions in plasma urea values, whereas plasma creatinine levels were somewhat lower after daily BST administration.

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Section: Discussionmentioning

confidence: 99%

Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone

Witkamp

Nijmeijer

Duin

et al. 1989

Vet Pharm & Therapeutics

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Changes in intramuscular fat, fatty acid profile and cholesterol content induced by zeranol implantation strategy in hair lambs

Valenzuela-Grijalva

González‐Ríos

Islava

et al. 2011

J. Sci. Food Agric.

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Natural sex steroids and their xenobiotic analogs in animal production: Growth, carcass quality, pharmacokinetics, metabolism, mode of action, residues, methods, and epidemiology

Lone

1997

Critical Reviews in Food Science and Nutrition

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Natural and xenobiotic compounds having sex-related actions have long been used for growth promotion and various changes in carcass quality in meat animals. The first compounds used were synthetic estrogens; however, later on a whole battery of compounds having androgenic, and progestogenic actions have also been involved. In surveying the effects of these compounds in meat-producing animals, it became clear that these drugs increase the growth rate of the treated animals and bring about changes in the carcass that are generally characterized by lower fat content and more lean mass. Extensive studies undertaken in various countries, including the European Economic Community (EEC), have shown that if used according to good husbandry practices, the meat from treated animals does not have excessive amounts of residues compared with the endogenous amount of steroid production in the animals in question and also in human beings. The banning of these compounds in the European community brought a new phenomenon of illegal or black market cocktails. These mixtures of anabolic steroids are injected into the body of the animals rather than implanted in the ears, which is the normal practice in countries where they have not yet been banned. Several screening and confirmatory methods are now available for monitoring programs. However, these programs need excessive resources in terms of manpower, funds, and proper legislation, which in underdeveloped countries is questionable, particularly in the absence of strong scientific evidence for the exercise.

show abstract

The efficacy, mode of action and safety of non-steroidal non-antimicrobial growth promoters

Cited by 4 publications

References 10 publications

Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone

Has bovine somatotropin (BST) an effect upon drug disposition? Comparative studies in goats and cattle with sulphadimidine and antipyrine after parenteral administration of BST, zeranol and proligestone

Changes in intramuscular fat, fatty acid profile and cholesterol content induced by zeranol implantation strategy in hair lambs

Natural sex steroids and their xenobiotic analogs in animal production: Growth, carcass quality, pharmacokinetics, metabolism, mode of action, residues, methods, and epidemiology

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