“…The management of these lesions could refer to previous reviews 6,7 . In terms of apatinib, commonly reported side effects of apatinib to include hematologic toxicity, proteinuria, hypertension, fatigue, nausea, vomiting et al 8 . Regarding cutaneous lesions, the handfoot syndrome (HFS) is the most common skin reaction, which may result in a 50.5% incidence 5 .…”