The Efficacy and Safety of Early Postoperative Botulinum Toxin A Injection for Facial Scars

Lee, Seo H.; Min, Hyung Jun; Kim, Yang W.; Cheon, Young Woo

doi:10.1007/s00266-017-1008-7

Cited by 43 publications

(64 citation statements)

References 24 publications

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“…Several studies (Table ) have been conducted to show the efficiency of BoNT‐A in surgical scars and wound healing. A study conducted by Lee et al found early postoperative BoNT‐A injection to be safe and effective in improving the scar qualities.…”

Section: Bont‐a In the Prevention And Treatment Of Pathological Scarsmentioning

confidence: 99%

Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review

Carrero

Liu

et al. 2018

J of Cosmetic Dermatology

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Botulinum Toxin Type A is a potent neurotoxin that is produced by a gram‐positive bacteria clostridium botulinum. Its utilization in the treatment of various medical condition has expanded over the years in both medical and esthetic uses. It is being preferred by most physicians due to its efficacy and lack of side effects. It can be used as monotherapy or combined therapy. The aim of this review study was to show the role and mechanism of action of Botulinum toxin type A in the treatment and prevention of hypertrophic scars and keloids. The clear mechanisms underlying hypertrophic scars and keloids are still not clearly understood; however, the mechanism of action of Botulinum toxin type A has been shown to include action on wound tension, action on collagen, and action on fibroblasts. Different randomized controlled trials, double‐blind, and placebo‐controlled studies have been conducted to investigate its use in treatment and prevention of hypertrophic scars and keloids, and it still is one of the active areas of research in Dermatology and related fields. Method: In March 2018, we performed a literature search in PubMed for clinical studies, clinical trials, case reports, controlled trials, randomized controlled trials, and systemic reviews. The search terms we used were “BOTULINUM TOXIN” AND “HYPERTROPHIC SCARS” OR “KELOIDS” (from 1980). The search resulted in 1000 articles, out of these 35 articles met our inclusion exclusion criteria. Our inclusion criteria included relevant original articles relevant, critical systemic reviews, and crucial referenced articles, exclusion criteria included duplicates and articles not published in English language. We have reviewed these papers to show the role and mechanism of action of Botulinum toxin type A in the treatment and prevention of hypertrophic scars and keloids.

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Section: Bont‐a In the Prevention And Treatment Of Pathological Scarsmentioning

confidence: 99%

Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review

Carrero

Liu

et al. 2018

J of Cosmetic Dermatology

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“…A total of 10 studies were included in the comparison, but two studies measured the data from two points, so there were 12 data in total (Figure ). The standardized mean difference (SMD) was chosen because of the large gap between the research results (0.32 ~ 3.25 mm).…”

Section: Resultsmentioning

confidence: 99%

“…A total of 9 studies were included in the comparison (Figure ) . The heterogeneity test suggested that there was heterogeneity between studies ( χ 2 = 139.16, P ＜ .00001, I 2 = 94%＞50%), so the random effect model was adopted for the combination, WMD = −1.82[95%CI: (−2.54,‐1.10), P ＜ .00001]; The results suggested that the VSS scores were significantly different between the two groups, and the VSS score was lower in the BTXA group than in the control group.…”

Section: Resultsmentioning

confidence: 99%

“…Ten of 18 studies reported adverse reactions . Besides transient pain, pruritus, and mild headache at the injection point, there were 2 cases of ptosis, 1 case of philtrum fixation wound, 1 case of asymmetrical smile, 1 case of asymmetric oral commissure, 1 case of asymmetric eyebrow, 1 case of abscess, and 1 case of ischemia.…”

Section: Resultsmentioning

confidence: 99%

“…Two meta‐analysis results published by Wang and Wang before including 9 studies respectively have showed that BTXA injection is a safe and effective treatment for scar prevention, but some recent studies have reached negative conclusions . Therefore, a larger range of meta‐analysis is needed for evidence support.…”

Section: Discussionmentioning

confidence: 99%

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The Safety and efficacy of botulinum toxin type A injection for postoperative scar prevention: A systematic review and meta‐analysis

Yang

2019

J of Cosmetic Dermatology

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Background Active prevention and treatment of scars are particularly important. Several studies have used botulinum toxin type A(BTXA) to prevent postoperative scarring. The aim of this systematic review and meta‐analysis was to systematically evaluate the efficacy and safety of BTXA in preventing and treating postoperative scars. Methods A computer‐based search was conducted for the five databases including PubMed, Cochrane Library, EMBASE, CNKI, and Wanfang up to May 22, 2019, to collect the relevant literatures on BTXA treatment of postoperative hypertrophic scars. A meta‐analysis was made with the software of Revman 5.3 based on the study endpoint of scar width, Vancouver Scar Scale (VSS), Visual Analogue Scale (VAS) scores, and patient satisfaction as well. Results A total of 18 randomized controlled trials (RCTs) studies were included with 915 patients in all. The result showed that, compared with the control group, the scar width, VAS scores, and VSS scores of the BTXA group were significantly improved and higher patient satisfaction was achieved. Conclusion BTXA has a certain curative effect on postoperative scar prevention and treatment without obvious side effects.

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Effectiveness and Safety of Botulinum Toxin Type A Injection for Scar Prevention: A Systematic Review and Meta-analysis

Wang

Zhang

et al. 2019

Aesth Plast Surg

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The Efficacy and Safety of Early Postoperative Botulinum Toxin A Injection for Facial Scars

Abstract: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Cited by 43 publications

References 24 publications

Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review

Botulinum toxin type A for the treatment and prevention of hypertrophic scars and keloids: Updated review

The Safety and efficacy of botulinum toxin type A injection for postoperative scar prevention: A systematic review and meta‐analysis

Effectiveness and Safety of Botulinum Toxin Type A Injection for Scar Prevention: A Systematic Review and Meta-analysis

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