The Efficacy and Safety of One‐Week Triple Therapy with Lansoprazole, Clarithromycin, and Metronidazole for the Treatment ofHelicobacter pyloriInfection in Japanese Patients

Takimoto, T; Satoh, Kiichi; Taniguchi, Yushi; Saifuku, Koji; Kihira, Ken; Seki, Masaru; Yoshida, Yukio; Ido, Kenichi; Kimura, Ken

doi:10.1111/j.1523-5378.1997.tb00064.x

Cited by 16 publications

(15 citation statements)

References 22 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The MACH 1 study has provided solid evidence favoring the efficacy of omeprazole-based regimens in H. pylori -infected patients with an eradication rate of 95–96% [13, 14, 15]. This has also been documented in trials including other proton pump inhibitors, like lansoprazole [16]and pantoprazole [17, 18], with similar results.…”

Section: Introductionsupporting

confidence: 52%

One-Week Triple Regime Therapy Consisting of Pantoprazole, Amoxicillin and Clarithromycin for Cure of Helicobacter pylori-Associated Upper Gastrointestinal Diseases

Dajani¹,

Awad²,

Ukabam³

et al. 1999

Digestion

View full text Add to dashboard Cite

This study was designed to determine the efficacy and safety of 1-week triple therapy regime consisting of pantoprazole, amoxicillin and clarithromycin in the cure of Helicobacter pylori infection leading to duodenal ulcer disease and/or gastritis. Sixty-one patients (47 males, 14 females with a mean age of 34 years) belonging to different ethnic groups suffering from H. pylori-associated duodenal ulcer and/or gastritis for an average of 2.46 years were recruited. Having satisfied primary selection criteria, patients received pantoprazole 40 mg b.i.d., clarithromycin 500 mg b.i.d. and amoxicillin 1,000 mg b.i.d. for 7 days. All medications were stopped there after H. pylori eradication was determined 4–6 weeks after treatment by a repeat endoscopy, a rapid urease test, H. pylori culture and histology assessment as indicators of cure. All three tests must be negative to consider the infection to have been successfully eradicated. Fifty-seven patients completed the efficacy analysis per protocol. Dramatic symptomatic improvement was noted in most patients immediately after stopping treatment and it was sustained at 6 weeks. At the end of the study, the healing rate of duodenal ulcers (complete re-epithelialization) following 1-week treatment only, as indicated above, and without any maintenance therapy was 66.7%, that of gastritis was 55.7%, and that of erosions was 64.3%. The overall eradication rate for H. pylori, however, was 93% (95% CI 83.0–98.1%). Furthermore, histologic evaluation revealed a remarkable resolution in the activity of gastritis in all the patients who had successful eradication of the infection.

show abstract

Section: Introductionsupporting

confidence: 52%

One-Week Triple Regime Therapy Consisting of Pantoprazole, Amoxicillin and Clarithromycin for Cure of Helicobacter pylori-Associated Upper Gastrointestinal Diseases

Dajani¹,

Awad²,

Ukabam³

et al. 1999

Digestion

View full text Add to dashboard Cite

show abstract

“…We have focused on documenting the side‐effects, which may account for the relatively high incidence compared with other studies 6 , . 8 , 10 , 26 , 27 However, patient compliance was very good in this study and only one patient withdrew from the study because of side‐effects. One of the major findings from our study was the significant reduction in the number of days with side‐effects with the use of a shorter regimen.…”

Section: Discussionmentioning

confidence: 73%

“…The reported eradication rates of lansoprazole, clarithromycin and metronidazole (LCM) triple therapy have varied from 78% to 92.3% 6 –9 . Few studies have focused on the impact of pre‐treatment antimicrobial resistance on the outcome of this regimen 7 .…”

Section: Discussionmentioning

confidence: 99%

Three‐day lansoprazole quadruple therapy for Helicobacter pylori‐positive duodenal ulcers: a randomized controlled study

Wong

Wang

Wong

et al. 2001

Aliment Pharmacol Ther

View full text Add to dashboard Cite

Aim: To compare the efficacy and tolerability of a 3‐day quadruple therapy with a standard 7‐day triple therapy in eradicating Helicobacter pylori infection and healing duodenal ulcers. Methods: Patients with H. pylori‐positive duodenal ulcers were randomized to receive either lansoprazole 30 mg, clarithromycin 500 mg, and metronidazole 400 mg twice daily for 7 days (LCM‐7) or lansoprazole 30 mg, clarithromycin 500 mg, metronidazole 400 mg, and bismuth subcitrate 240 mg twice daily for 3 days (LCMB‐3). No pre‐ or post‐treatment acid suppression was used. Follow‐up endoscopy was performed at week 6. Results: A total of 118 patients were recruited. Sixty patients in the LCM‐7 group and 53 patients in the LCMB‐3 group returned for endoscopy. Intention‐to‐treat eradication rates were 87% and 86% (P=0.94) and per protocol eradication rates were 87% and 94% (P=0.29) in the LCM‐7 and LCMB‐3 groups, respectively. Per protocol and intention‐to‐treat ulcer healing rates were 98% and 98% in LCM‐7 and 100% and 91% in LCMB‐3, respectively. There were no significant differences in efficacy in relation to the initial metronidazole and clarithromycin susceptibility. Significant reduction in the duration of side‐effects was found in the LCMB‐3 group. Conclusion: The 3‐day quadruple therapy is highly effective, better tolerated and can be considered as a first‐line therapy in duodenal ulcer management.

show abstract

“…A total of 73 studies (57 papers and 16 abstracts) were included in this systematic overview. 10–82 Of those, 60 were randomized controlled trials. The study design was unclear or unstated in 13 reports.…”

Section: Resultsmentioning

confidence: 99%

Pooled analysis of Helicobacter pylori eradication regimes in Asia

Wang

Wong

Lam

2000

J of Gastro and Hepatol

View full text Add to dashboard Cite

Proton pump inhibitor-based triple therapy with either clarithromycin, amoxycillin or metronidazole was one of the most commonly used and effective anti-H. pylori triple therapy regimens in Asia. The classical triple therapy with a bismuth, tetracycline and metronidazole combination has a similar efficacy. The results of anti-H. pylori treatment in Asia are not different from those in Western countries.

show abstract

The Efficacy and Safety of One‐Week Triple Therapy with Lansoprazole, Clarithromycin, and Metronidazole for the Treatment ofHelicobacter pyloriInfection in Japanese Patients

Cited by 16 publications

References 22 publications

One-Week Triple Regime Therapy Consisting of Pantoprazole, Amoxicillin and Clarithromycin for Cure of <i>Helicobacter pylori</i>-Associated Upper Gastrointestinal Diseases

One-Week Triple Regime Therapy Consisting of Pantoprazole, Amoxicillin and Clarithromycin for Cure of <i>Helicobacter pylori</i>-Associated Upper Gastrointestinal Diseases

Three‐day lansoprazole quadruple therapy for Helicobacter pylori‐positive duodenal ulcers: a randomized controlled study

Pooled analysis of Helicobacter pylori eradication regimes in Asia

Contact Info

Product

Resources

About