The Efficacy and Safety of a 755-nm Picosecond Laser in the Treatment of Physiologic Lip Hyperpigmentation in Thai Patients

Abstract

BACKGROUND Physiologic lip hyperpigmentation is a common aesthetic concern, especially in Southeast Asia. There is limited data on the application of the picosecond laser for this condition. OBJECTIVE To evaluate the efficacy and safety of using a 755-nm picosecond laser in the treatment of physiologic lip hyperpigmentation. METHODS Twenty healthy patients with physiologic lip hyperpigmentation received 5 bi-weekly treatments with a 755nm picosecond laser using a 6-mm spot size, fluence of 0.71 J/cm 2 at 5 Hz. Subjective and objective evaluation on the improvement of lip hyperpigmentation were obtained at baseline, 2 weeks after each treatment and at 1, 3, and 6 months after the final treatment. Patient self-assessment, pain score, and adverse reactions were also recorded. RESULTS All patients completed the study and attended all follow-ups. Most (52.6%) patients presented with moderate clinical improvement at 6-month follow-up. The average melanin index decreased significantly after the fourth treatment (p 5 .048) and at 1-month follow-up (p 5 .026). More than half the patients (70%) reported moderate-to-marked improvement at 6-month follow-up. Only 1 patient presented with a transient adverse reaction of lip edema. CONCLUSION The 755-nm picosecond laser is safe and effective for the treatment of physiologic lip hyperpigmentation in Thai patients.

Evaluation of the Efficacy of the 755 nm Picosecond Laser in Eliminating Pigmented Skin Lesions after a Single Treatment Based on Photographic Analysis with Polarised Light

“…Additionally, a number of persons recruited for our study exceeds what has been described so far in the literature. For instance, Woraphong Manuskiatti [29] randomized 18 patients, Ng et al recruited 20 patients [30] and Bonan et al enrolled 63 patients [24]. Chesnut et al provided data on three patients [31] so as Huang [32], whilst Fabi et al evaluated the efficacy in 20 patients [33] and Yiming Li analysed 37 persons [34].…”