The efficacy and safety of yukmijihwang-hwan (Liuweidihuang-wan) for type 2 diabetes mellitus without complications

Baek, Ji-Soo; Kim, Jinmi; Shin, Seon-Mi; Cho, Chungsik

doi:10.1097/md.0000000000029087

Cited by 4 publications

(2 citation statements)

References 5 publications

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“…In the long-term clinical application and clinical trials, no liver and kidney toxicity and adverse reactions to Liuwei Dihuang pill were observed [ 6 , 20 ]. Previous studies show that the central nervous system, respiratory system, and cardiovascular system of mice and rats were normal after oral administration of Liuwei Dihuang 15 g·kg –1 , while there was no death in mice and rats after 14 days of administration of 15 g·kg –1 Liuwei Dihuang either [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Network pharmacology and molecular docking approach to elucidate the mechanisms of Liuwei Dihuang pill in diabetic osteoporosis

Huang

Lin

et al. 2022

J Orthop Surg Res

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Background Diabetic osteoporosis (DOP) is one of the chronic complications of diabetes mellitus, but without a standardized treatment plan till now. Liuwei Dihuang pill (LDP) has gradually exerted a remarkable effect on DOP in recent years; its specific mechanism is not clear yet. Methods We adopted network pharmacology approaches, including multi-database search, pharmacokinetic screening, network construction analysis, gene ontology enrichment analysis, Kyoto Encyclopedia of Genes and Genomes pathway analysis and molecular docking to elaborate the active components, signaling pathways and potential mechanisms of LDP in the treatment of DOP. Results Twenty-seven active ingredients and 55 related disease targets have been found through integrated network pharmacology. Functional enrichment analysis shows that five key active ingredients, including beta-sitosterol, stigmasterol, diosgenin, tetrahydroalstonine, and kadsurenone, may give full scope to insulin secretion estrogen-level raising and angiogenesis in biological process through the pivotal targets. In addition, the underlying effect of PI3K/AKT/FOXO and VEGF pathways is also suggested in the treatment. Conclusion Based on systematic network pharmacology methods, we predicted the basic pharmacological effects and potential mechanisms of LDP in the treatment of DOP, revealing that LDP may treat DOP through multiple targets and multiple signaling pathways, which provide evidence for the further study of pharmacological mechanism and broader clinical thinking.

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Section: Resultsmentioning

confidence: 99%

Network pharmacology and molecular docking approach to elucidate the mechanisms of Liuwei Dihuang pill in diabetic osteoporosis

Huang

Lin

et al. 2022

J Orthop Surg Res

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“…Some formulas using Rehmannia as the main herb have gradually developed into proprietary Chinese medicines, such as Six Drugs, Yougui Pill, and Jin Kui Shen Qi Wan. Bolus of Six Drugs is commonly used to treat diseases such as diabetes (Baek et al, 2022), osteoporosis(R. , and atherosclerosis(Q. . Lycium-Rehmannia pills can be used to treat dry eye syndrome (Lou et al, 2020).…”

Section: Chinese Medicine Formula Of Rehmanniae Radixmentioning

confidence: 99%

Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix.

Jia,

Chen,

Wang

et al. 2023

Preprint

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The traditional Chinese medicine (TCM) Rehmanniae Radix (RR) refers to the fresh or dried root tuber of the plant Rehmannia glutinosa Libosch of the family Scrophulariaceae. As a traditional Chinese herbal medicine (CHM), it possesses multiple effects, including analgesia, sedation, anti-inflammation, antioxidation, anti-tumor, immunomodulation, cardiovascular and cerebrovascular regulation, and nerve damage repair, and it has been widely used in clinical practice. In recent years, scientists have extensively studied the active components and pharmacological effects of RR. Active ingredients mainly include iridoid glycosides (such as catalpol and aucuboside), phenylpropanoid glycosides (such as acteoside), other saccharides, and unsaturated fatty acids. In addition, the Chinese patent medicine (CPM) and Chinese decoction related to RR have also become major research subjects for TCM practitioners; one example is the Bolus of Six Drugs, which includes Rehmannia, Lily Bulb and Rehmannia Decoction, and Siwu Decoction. This article reviews recent literature on RR; summarizes the studies on its chemical constituents, pharmacological effects, and clinical applications; and analyzes the progress and limitations of current investigations to provide reference for further exploration and development of RR.

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Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden

Wu,

Yoshino,

Maeda-Minami

et al. 2024

Sci Rep

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Temperature perception is essential for humans to discern the environment and maintain homeostasis. However, some individuals experience cold hypersensitivity, characterized by a subjective feeling of coldness despite ambient environmental temperatures being normal, the underlying mechanisms of which are unknown. In this study, we aimed to investigate the relationship between subjective cold symptoms and somatic burden or single nucleotide polymorphisms to understand the causes of cold hypersensitivity. We conducted an online questionnaire survey [comprising 30 questions, including past medical history, subjective symptoms of cold hypersensitivity, and the Somatic Symptom Scale-8 (SSS-8)]. Respondents were 1200 Japanese adult female volunteers (age: 20–59 years), recruited between April 21 and May 25, 2022, who were customers of MYCODE, a personal genome service in Japan. Among the 1111 participants, 599 (54%) reported cold hypersensitivity. Higher cold hypersensitivity severity was positively associated with the SSS-8 scores. Additionally, a genome-wide association study for cold hypersensitivity was conducted using array-based genomic data obtained from genetic testing. We identified 11 lead variants showing suggestive associations (P < 1 × 10–5) with cold hypersensitivity, some of which showed a reasonable change in expression in specific tissues in the Genotype-Tissue Expression database. The study findings shed light on the underlying causes of cold hypersensitivity.

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The efficacy and safety of yukmijihwang-hwan (Liuweidihuang-wan) for type 2 diabetes mellitus without complications

Cited by 4 publications

References 5 publications

Network pharmacology and molecular docking approach to elucidate the mechanisms of Liuwei Dihuang pill in diabetic osteoporosis

Network pharmacology and molecular docking approach to elucidate the mechanisms of Liuwei Dihuang pill in diabetic osteoporosis

Progress of research into the pharmacological effect and clinical application of the traditional Chinese medicine Rehmanniae Radix.

Exploratory study of cold hypersensitivity in Japanese women: genetic associations and somatic symptom burden

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