The Efficacy and Safety of Fentanyl Buccal Tablet Compared with Immediate-Release Oxycodone for the Management of Breakthrough Pain in Opioid-Tolerant Patients with Chronic Pain

Abstract

FBT resulted in more rapid onset of analgesia and was generally well tolerated in comparison with oxycodone for the treatment of BTP in opioid-tolerant patients.

Fentanyl Buccal Tablet vs. Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Randomized, Crossover, Comparison Study

“…23 In a randomized, double-blind, double-dummy comparison study with oral oxycodone, the differences in the decrease of pain intensity after 15 and 30 minutes, 0.22e0.33 points on NRS, respectively, although significant, were clinically negligible because they were largely less of one point. After 15 and 30 minutes, meaningful pain relief was observed in 16% and 45%, respectively, of episodes treated with FBT; at the same time intervals, only in 13% and 41% of episodes was there a pain decrease $33% and $50%, respectively.…”

How practical are transmucosal fentanyl products for breakthrough cancer pain? novel use of placebo formulations to survey user opinion: Table 1

“…They are similar in cost (about £5 (US$8) per dose), are more effective than placebo, but have not been directly compared with orally administered analgesics or with each other in patients with cancer 7. Such comparison is limited to the buccal/sublingual tablet and oxycodone in patients with chronic non-cancer pain 8. This makes selecting the most appropriate product to use difficult.…”

Fentanyl for the Treatment of Tumor-Related Breakthrough Pain

“…The numbers of episodes with 33% or 50% pain reduction were 13% versus 9% and 6% versus 4%, respectively, after 15 minutes, and 41% versus 32% and 21% versus 16%, respectively, after 30 minutes (NNT between 11 and 50). There was no difference in type and severity of adverse effects (15).…”