The efficacy and safety of fractional erbium yag laser combined with topical amniotic membrane stem cell (AMSC) metabolite product for facial rejuvenation: A controlled, split-face study

Widianingsih, Ni Putu Susari; Setyaningrum, Trisniartami; Prakoeswa, Cita Rosita Sigit

doi:10.4081/dr.2019.8036

Cited by 3 publications

(3 citation statements)

References 5 publications

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“…The study selection process is summarized in Figure 1. From a total of 399 records, 12 studies were eligible and included in the data analysis [8][9][10][11][12][13][14][15][16][17][18][19].…”

Section: Resultsmentioning

confidence: 99%

“…The RCT of Widianingsih et al evaluated the outcomes of Er:YAG laser-assisted amniotic membrane stem cell (AMSC) metabolite product delivery following three sessions at 4-week intervals [14]. At 3 months follow-up, a slightly better but not significant result in the AMSC compared to the saline side was observed in terms of pores, wrinkles, pigmentation, and skin tone.…”

Section: Facial Rejuvenation and Rhytidesmentioning

confidence: 99%

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Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

Seretis,

Papaioannou

2023

Cosmetics

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Laser-assisted drug delivery (LADD) has gained prominence as a promising technique with the potential to enhance topical drug skin penetration and absorption. However, the effectiveness of various laser-assisted facial procedures remains unclear. This systematic review aimed to explore and summarize the evidence regarding the indications, clinical outcomes, and adverse effects of LADD performed on the face. Based on a predetermined protocol, an electronic search in MEDLINE, Scopus, the Cochrane Library, and CENTRAL electronic databases was conducted. Eligible studies comprised prospective controlled trials that explored the utility of laser-assisted techniques for topical medication facial application and reported on efficacy and/or safety. Secondary outcomes encompassed patient satisfaction. This review included 12 prospective controlled studies involving a total of 271 participants. LADD, through various laser types, topical medications, clinical protocols, and follow-up assessments, showed enhanced melasma, facial rejuvenation, scar, and periprocedural laser outcomes without increased risk of adverse effects. This review provides evidence that LADD is an effective and safe adjunct for various facial procedures. It also highlights the necessity for further high-quality studies with larger sample sizes, standardized treatment protocols, and evaluation of long-term outcomes and adverse effects in order to elucidate the potential of laser-assisted drug delivery.

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Section: Resultsmentioning

confidence: 99%

Section: Facial Rejuvenation and Rhytidesmentioning

confidence: 99%

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

Seretis,

Papaioannou

2023

Cosmetics

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“…Split-face research on the efficacy and safety of AMSC-CM after Er-Yag laser showed a more significant repair in pores compared to normal saline. [ 15 ] Rahmadewi has also published a study on AMSC metabolite product and vitamin E after laser fractional CO 2 and reported improved pores in photoaging patients. [ 16 ]…”

Section: Discussionmentioning

confidence: 99%

The Comparison between Microneedling and Fractional CO2 Laser for Amniotic Membrane Stem Cell-Conditioned Medium and Vitamin C in Photoaging Treatment

Indramaya,

Listiawan,

Citrashanty

et al. 2023

Indian Journal of Dermatology

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Context: Photoaging correlates with ultraviolet radiation (UVR). In addition to direct and indirect DNA damage, UVR leads to a breakdown of collagen, resulting in enlarged pores, visible wrinkles, also uneven skin tones and pigmentations. Amniotic membrane stem cell (AMSC) can be a useful modality in cell regeneration. Vitamin C has been known as an agent of depigmentation, antioxidants, and collagen synthesis. A topical combination of amniotic membrane stem cell-conditioned medium (AMSC-CM) and vitamin C is expected to improve photoaging. Fractional CO 2 laser and microneedling served as transdermal drug delivery. Aims: To compare between microneedling and fractional CO 2 laser for the administration of AMSC-CM and vitamin C in photoaging treatment. Methods and Material: Sixty Indonesian women with photoaged skins participated in this experimental analytic, controlled, matching research and were divided into two groups. Thirty women received fractional CO 2 laser, and others received microneedling. All participants received a topical combination of AMSC-CM and vitamin C. Three treatment sessions were repeated at a four-week interval for fractional CO 2 laser and a two-week interval for microneedling. We evaluated the progression and side effects using a skin analyzer on weeks 0, 4, and 8 for the microneedling group and for the fractional CO 2 laser group on weeks 0, 4, and 12. Results: Assessment of wrinkles, UV spots, skin tone, and pore revealed a statistically significant effect of a topical combination of AMSC-CM and vitamin C after fractional CO 2 laser ( p < 0.05). Conclusions: Combination of AMSC-CM and vitamin c using fractional CO 2 laser can improve photoaging and is better compared to microneedling.

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Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events

Smith

2022

Pharmaceutics

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Laser-assisted drug delivery (LADD) is an increasingly studied and applied methodology for drug delivery. It has been used in a wide variety of clinical applications. Given the relatively low barrier to entry for clinicians as well as ongoing research in this area, the authors aimed to review outcomes relating to safety in laser-assisted drug delivery. A systematic review was conducted, with the databases PubMed, Medline and Embase searched in September 2022. Included articles were those that mentioned laser-assisted drug delivery in human subjects that also reported adverse effects or safety outcomes. There were no language-based exclusions. Conference abstracts and literature reviews were excluded. The results were then tabulated and categorized according to the application of LADD. In total, 501 articles were obtained. Following deduplication, screening, and full text review 70 articles of various study designs were included. Common findings were erythema, oedema, pain, and crusting following LADD. Several notably more severe adverse effects such as generalized urticaria, infection, scarring and dyspigmentation were noted. However, these events were varied depending on the clinical use of LADD. Relevant negatives were also noted whereby no studies reported life-threatening adverse effects. Limitations included limited details regarding the adverse effects within the full texts, lack of follow-up, and risk of bias. In conclusion, there were multiple adverse effects that clinicians should consider prior to carrying out LADD, where treatment goals and patient tolerability should be considered. Further evidence is needed to quantitatively determine these risks.

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The efficacy and safety of fractional erbium yag laser combined with topical amniotic membrane stem cell (AMSC) metabolite product for facial rejuvenation: A controlled, split-face study

Cited by 3 publications

References 5 publications

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

Laser-Assisted Drug Delivery on the Face: A Systematic Review of Indications and Outcomes

The Comparison between Microneedling and Fractional CO2 Laser for Amniotic Membrane Stem Cell-Conditioned Medium and Vitamin C in Photoaging Treatment

Laser-Assisted Drug Delivery: A Systematic Review of Safety and Adverse Events

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