The Efficacy and Safety of Chitosan on Facial Skin Sebum

Abstract

Introduction: Seborrhea or oily skin has been one of the most common complaints affecting both men and women physically and psychologically. Chitosan is a biopolymer obtained from the alkaline deacetylation of chitin. Due to its positively charged nature, chitosan can effectively bind to lipids. Therefore, chitosan nanoparticle (CN) formulation may benefit in the reduction of skin sebum. Objective: The aim of this study was to evaluate the efficacy and safety of CN formulation in the reduction of skin sebum. Method: The study was a randomized, double-blinded, placebo-controlled trial in 24 participants aged 18–40 years with clinical seborrhea. Participants were randomly assigned to apply the CN and gum (CN-G) or placebo (gum alone) twice daily for 4 weeks. Sebum level, corneometry, transepidermal water loss (TEWL), and clinical seborrhea grading were evaluated at baseline and week 2 and 4. Results: In the T-zone, sebum levels in the CN-G group were significantly lower than the placebo group at week 4 (p = 0.043), while for the U-zone, sebum levels were not different between groups. There were no statistical differences in corneometry and TEWL at any visit. Although the clinical seborrhea grading in CN-G was lower, it was not significantly different from the placebo. A few cases reported mild and self-limiting scaling and acneiform eruption. Conclusion: The CN-G gel could significantly reduce sebum levels on seborrhea patients with acceptable safety profiles.

Chitin, Chitosan, and Nanochitin: Extraction, Synthesis, and Applications

“…Due to the positive charge on chitosan, it can act as a humectant to maintain skin moisture or strengthen hair and act as a conditioner through interactions with hair keratin [ 126 ]. Suspensions of chitosan nanoparticles in guar gum have been indicated to reduce skin sebum levels in seborrhea patients [ 127 ]. Azimi et al found that chitin nanofibrils electrosprayed onto cellulose films improved compatibility with skin cells and downregulated inflammatory cytokines, indicating potential applications for nanochitin in cosmetics [ 128 ].…”

Implementasi Fuzzy Tsukamoto Dan Algoritma Genetika Pada Pemilihan Skincare

“…Gangguan kesehatan kulit yang sering dialami oleh pasien di Klinik Nanisa adalah pembesaran pori-pori wajah, komedo, dan telangiactasis. Gangguan kesehatan yang pertama adalah pori-pori wajah yang membesar dapat disebabkan oleh perbedaan jenis kelamin, kecenderungan genetik, penuaan, paparan sinar ultraviolet kronis, xenobiotik komedogenik, jerawat, dan seborrhoea [10]. Selain pori-pori membesar, komedo juga menjadi permasalahan yang sering ditemui pada pasien.…”

Chitosan: A Promising Multifunctional Cosmetic Ingredient for Skin and Hair Care

“…Thus, the interaction between the positive charges of the chitosan backbone and the anionic charges of the skin surface can be exploited as a very promising tool for ensuring the targeted release of cleaners [70]. Moreover, Theerawattanawit et al [71] demonstrated that chitosan gels may be exploited for reducing sebum levels without any side effects.…”