The efficacy and safety of fexofenadine HCl and pseudoephedrine, alone and in combination, in seasonal allergic rhinitis☆☆☆★

Sussman, Gordon; Mason, Jolene; Compton, Diana; Stewart, John A.; Ricard, Nancy

doi:10.1016/s0091-6749(99)70120-x

Cited by 62 publications

(39 citation statements)

References 19 publications

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“…In many countries, the combination of oral H 1 -antihistamines and decongestants represents a large market share (1612)(1613)(1614)(1615). The objectives of these combinations are to improve nasal obstruction which shows little change using oral H 1 -antihistamines.…”

Section: 27mentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,812

1,761

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Section: 27mentioning

confidence: 99%

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Bousquet¹,

Khaltaev²,

Cruz³

et al. 2008

Allergy

3,812

1,761

View full text Add to dashboard Cite

“…177,178 Second, companies claiming anti-inflammatory effects of their antihistamine have often added an oral vasoconstrictor to the antihistamine, which improves the efficacy on nasal blockage. [179][180][181] This addition is a reflection of the lack of effect of the antihistamine as a sole therapy. LEUKOTRIENE RECEPTOR ANTAGONISTS.…”

Section: Effect On Nasal Inflammationmentioning

confidence: 99%

Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication

Åkerlund

Andersson

Leflein³

et al. 2005

Journal of Allergy and Clinical Immunology

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“…1 In a review of 16 human pharmacokinetic studies, Chen et al reported that the half-life of fexofenadine varies between 3 and 17 hours. 9 In our study, the half-life of fexofenadine w/o microemulsion was significantly (P , 0.05) decreased (by 2.04-fold) when compared with a commercial fexofenadine syrup (Fexofen ® , Sanovel, Istanbul, Turkey) because of differences in clearance rates and distribution volumes for the two formulations.…”

Section: Introductionmentioning

confidence: 99%

Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies

Gündoğdu¹,

Álvarez²,

Karasulu³

2011

IJN

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Fexofenadine (FEX) has high solubility and low permeability (BCS, Class III). In this work, novel FEX loaded water in oil microemulsion (w/o) was designed to improve bioavailability and compared with Fexofen ® syrup in in vitro and in vivo studies. In addition, pharmacokinetic parameters in permeability studies were estimated by using WinNonLin software program. w/o microemulsion system was optimized using a pseudoternary phase diagram, composed of span 80/lutrol F 68 (9.5:0.5 w/w), oleic acide, isopropyl alcohol and water as surfactant mixture; oil and cosurfactant was developed for oral drug delivery. w/o microemulsion systems were characterized by phase behavior, particle size, viscosity and solubilization capacity. In vitro studies were studied using Caco-2 cell monolayer. Pharmacokinetic parameters of w/o microemulsion were investigated in rabbits and compared to Fexofen ® syrup. Fexofen ® syrup and microemulsion were administered by oral gavage at 6 mg/kg of the same concentration. The experimental results indicated that microemulsion (HLB = 5.53) formed nanometer sized droplets (33.29 ± 1.76) and had good physical stability. This microemulsion increased the oral bioavailability of FEX which was highly water-soluble but fairly impermeable. The relative bioavailability of FEX microemulsion was about 376.76% compared with commercial syrup in rabbits. In vitro experiments were further employed for the enhanced effect of the microemulsion for FEX. These results suggest that novel w/o microemulsion plays an important role in enhancing oral bioavailability of low permeability drugs.

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The efficacy and safety of fexofenadine HCl and pseudoephedrine, alone and in combination, in seasonal allergic rhinitis☆☆☆★

Cited by 62 publications

References 19 publications

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Allergic Rhinitis and its Impact on Asthma (ARIA) 2008*

Clinical trial design, nasal allergen challenge models, and considerations of relevance to pediatrics, nasal polyposis, and different classes of medication

Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies

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