The Efficacy and Safety of Sertaconazole Cream (2 %) in Diaper Dermatitis Candidiasis

Abstract

AimDiaper dermatitis (DD) is an inflammatory irritating condition that is common in infants. Most cases are associated with the yeast colonization of Candida or diaper dermatitis candidiasis (DDC), and therefore, the signs and symptoms improve with antimycotic treatment. Sertaconazole is a broad-spectrum third-generation imidazole derivative that is effective and safe for the treatment for superficial mycoses, such as tineas, candidiasis, and pityriasis versicolor. Our goal was to assess the efficacy and safety of sertaconazole cream (2 %) in DDC.Materials and methodsTwenty-seven patients with clinical and mycological diagnosis of DDC were enrolled and treated with 2 daily applications for 14 days and were followed-up for 2 further weeks.ResultsThree etiologic agents were isolated: Candida albicans in 88.8 %, Candida parapsilosis in 7.3 %, and Candida glabrata in 3.2 %. There was an average symptom reduction from 7.1 to 3.2 in the middle of treatment and to 1.2 and 0.4 units at the end of treatment and follow-up, respectively. The treatment evaluation at the end of the follow-up period showed a total clinical and mycological cure in 88.8 %, improvement in 3.7 %, and failure in 7.4 %. There was side effect (3.7 %) of skin irritation, but the drug was not discontinued.ConclusionsBased on its safety and effectiveness, sertaconazole cream may be considered a new alternative for DDC treatment.

Enhanced antifungal effects of amphotericin B-TPGS-b-(PCL-ran-PGA) nanoparticles in vitro and in vivo

“…This upward trend is concerning considering the limited number of antifungal drugs available. 5 Therefore, there is an urgent need for the development of new antifungal agents.…”

“…In addition, ADRs, such as kidney damage, hypokalemia, and even thrombophlebitis, are also common and may be occasionally serious. 5 The lipid formulations of AMB may alleviate the toxicity and increase the bioavailability of AMB. 5,6 Nevertheless, the high cost of these formulations puts them beyond the reach of most of patients with fungal infection.…”

Zinc Oxide 30% and Tocopherol Compared to 10% Zinc Oxide Ointment in the Treatment of Infant's Diaper Dermatitis: A Triple Blinded Controlled Randomized Trial

“…In multiple clinical studies, mycosis has been isolated in up to 80% [6] of children with DD which can be present for even three or more days [7]. Once the stratum corneum has been damaged the skin is more vulnerable to secondary infections by bacteria and fungi.…”

“…Once the stratum corneum has been damaged the skin is more vulnerable to secondary infections by bacteria and fungi. Ferrazzini [7] found that colonization with Candida albicans was significantly increased in children with symptomatic diaper rash. A wide variety of other infections has been reported but it appears that Candida is the most common opportunistic invader in diaper areas.…”

“…Not all patients respond equally to skin protective agents, and when DD is present for more than 72 hours' colonization plays a more important role in the pathology [1,16]. According to literature [7,8] a department internal research confirmed 80% DD frequency on population. Nitzan and Cohen [17] said that there was a very little evidence demonstrating convincingly the efficacy of zinc as a first-line treatment for any dermatological condition, furthermore many authors highlighted the correlation of colonization and DD patients [10].…”