The efficacy and safety of posterior scleral reinforcement using genipin cross-linked sclera for macular detachment and retinoschisis in highly myopic eyes

Zhu, Siquan; Zheng, Linyan; Pan, An-Peng; Yu, A-Yong; Wang, Qinmei; Xue, Anquan

doi:10.1136/bjophthalmol-2015-308087

Cited by 22 publications

(31 citation statements)

References 19 publications

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“…Combining PSR with PPV might be an effective approach in treating unclosed MH. In our previous study,16 the genipin cross linking of allogeneic sclera is beneficial to the control of AL. The reinforcement effect was well maintained with an average decrease in AL of 2.15±0.56 mm in more than a 1-year period.…”

Section: Discussionmentioning

confidence: 89%

“…Macular buckling combined with vitrectomy was an effective approach in treating myopic MHRD, because they released the traction caused by intraocular and outer ocular forces. PSR16 shortens the AL and relieves the outer traction on the retina. The surgical technique is also conducive to make the retinal pigmented epithelium layers closer to the neurosensory layer.…”

Section: Discussionmentioning

confidence: 99%

“…The surgical technique of PSR was published previously 16. The procedure was improved by shortening the AL of the diseased eye and more force was applied to the scleral strips to achieve better therapeutic efficacy for patients with MH and retinal detachment.…”

Section: Methodsmentioning

confidence: 99%

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Posterior scleral reinforcement using genipin-cross-linked sclera for macular hole retinal detachment in highly myopic eyes

et al. 2018

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Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

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Posterior scleral reinforcement using genipin-cross-linked sclera for macular hole retinal detachment in highly myopic eyes

et al. 2018

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“…Its antimyofibroblast activity was also studied as a way to prevent posterior capsular opacification in cataract surgery [29]. Recently it has even been suggested as an efficient and safe treatment for macular detachment and retinoschisis in highly myopic eyes using a genipin cross-linked sclera as reinforcement [30]. Genipin is known for its excellent biocompatibility [31].…”

Section: Discussionmentioning

confidence: 99%

Optimizing Genipin Concentration for Corneal Collagen Cross-Linking: An ex vivo Study

et al. 2018

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Purpose: Studying genipin variable concentrations, treatment durations, and delivery methods as a substance to increase corneal stiffness by inducing corneal collagen cross-linking (CXL). Materials and Methods: 100 bovine corneas treated with different genipin concentrations (0.1, 0.5, and 1%) and treatment durations (15 min, 40 min, 2 h, and 3 days) through different delivery methods compared to 10 controls treated with riboflavin/UV. Histology examination, enzymatic digestion with collagenase and thermal differential scanning calorimetry were performed on the different samples. Results: Bovine corneas soaked in 0.5% genipin morphologically showed 4.7% CXL in comparison to 5.6% in controls (p < 0.05). Corneas treated with topical 0.5% genipin, by a 140-µL drop applied hourly for 2 h, showed 7% corneal CXL. Corneas treated with topical genipin 0.5% for 30 min, 1 and 2 h showed 54 ± 6, 40 ± 7, and 39 ± 9% enzymatic degradation, respectively, in comparison to controls (74%). Corneas treated with 0.5% genipin for 1, 2, and 8 h showed higher thermal denaturation resistance (Td values of 64.9 ± 0.3, 64.7 ± 0.0 and 67.3 ± 0.9), respectively, in comparison to the control group (64.6 ± 0.5) (p < 0.05). Conclusions: Genipin 0.5%, in a 140-µL drop applied hourly for 2 h, showed better potential to enhance corneal stiffness and stability through inducing CXL.

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“…articular cartilage, human patella tendons, and posterior scleral reinforcement with excellent biocompatibility. [23][24][25] Genipin is definitely a superior crosslinking agent due to its stability, biocompatibility, and general safety.…”

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confidence: 99%

Genipin-Crosslinked Donor Sclera for Posterior Scleral Contraction/Reinforcement to Fight Progressive Myopia

Xue

Zheng

Tan

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Myopia has become a global public health problem, particularly in East Asia where myopic retinopathy has become one of the leading causes of blindness and visual impairment in the elderly population. The purpose of this study was to evaluate the efficacy of posterior scleral contraction/reinforcement (PSCR) surgery on controlling the progressive elongation of axial length of highly myopic eyes in young patients.METHODS. This is a prospective self-controlled interventional case series. Forty young patients (<18-years old) with progressive high myopia received PSCR with a genipin-crosslinked donor scleral strip for one eye and the fellow eye served as concurrent control without surgery. The main outcome measurement was the change of axial length over 2 to 3 years of follow-up. RESULTS.Immediately after the surgery, axial length was shortened and subsequently increased by 0.32 mm over the follow-up period. In contrast, axial length of the fellow eyes increased by 0.82 mm over the same period (P < 0.001, paired t-test). PSCR delayed axial elongation in eyes with or without staphyloma. No significant change of visual acuity, cornea refractive power, or retina thickness was noted between the surgery and fellow eyes. None of the patients lost visual acuity compared with the baseline. The procedure was well tolerated with only temporary corneal refractive axis shifts that recovered by the 6-month postsurgical visit.CONCLUSIONS. PSCR with genipin-crosslinked sclera is safe and effective to restrain eye globe elongation in young patients within a 2-to 3-year follow-up period.

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The efficacy and safety of posterior scleral reinforcement using genipin cross-linked sclera for macular detachment and retinoschisis in highly myopic eyes

Cited by 22 publications

References 19 publications

Posterior scleral reinforcement using genipin-cross-linked sclera for macular hole retinal detachment in highly myopic eyes

Posterior scleral reinforcement using genipin-cross-linked sclera for macular hole retinal detachment in highly myopic eyes

Optimizing Genipin Concentration for Corneal Collagen Cross-Linking: An ex vivo Study

Genipin-Crosslinked Donor Sclera for Posterior Scleral Contraction/Reinforcement to Fight Progressive Myopia

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