The Efficacy and Safety of the Chinese Herbal Formula, JTTZ, for the Treatment of Type 2 Diabetes with Obesity and Hyperlipidemia: A Multicenter Randomized, Positive-Controlled, Open-Label Clinical Trial

Yu, Xiaotong; Xu, Li; Zhou, Qiang; Wu, Shengping; Tian, Jiaxing; Piao, Chunli; Guo, Hailong; Zhang, Jun; Li, Liping; Wu, Shentao; Guo, Meizhen; Hong, Yuzhi; Pu, Weirong; Zhao, Xiao-Feng; Yang, Liu; Pang, Bing; Peng, Zhiping; Wang, Song; Lian, Fengmei; Tong, Xiaolin

doi:10.1155/2018/9519231

Cited by 27 publications

(45 citation statements)

References 35 publications

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“…This reduction in glucose levels represented a decrease of 52.6% ( p < .003) by fermented juice of M. citrifolia in Sprague‐Dawley male rats (Nayak et al, ). There are reports addressing an increasing number of Type 2 diabetes patients with concomitant obesity and hyperlipidemia syndromes (Yu et al, ). The ethanolic extract of M. citrifolia displayed higher porcine pancreatic lipase activity (75%) at 500–1,000 μg/ml concentration (Saraphanchotiwitthaya & Sripalakit, ).…”

Section: Discussionmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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Section: Discussionmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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“…The inhibitory effects on various enzymes that are related to carbohydrate metabolism, such as amylase and glycosidase (Lu et al, ; Sabitha, Panneerselvam, & Ramachandran, ; Zeng et al, ) along with the antioxidant capacity of this this plant, may relate to its antidiabetic property. There are reports addressing an increasing number of Type 2 diabetes patients with concomitant obesity and hyperlipidemia syndromes (Yu et al, ). Therefore, the lipid‐lowering capacity of the plant (Ngoc et al, ; Sabitha et al, ) may also be a positive indication for the management of these types of diseases.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical information and pharmacological activities of Okra (Abelmoschus esculentus): A literature‐based review

Islam

2018

Phytotherapy Research

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The findings suggest that A. esculentus contains various nutrients and important phytochemicals. It possesses a number of important biological activities, including antioxidant, anti-inflammatory and immunomodulatory, antibacterial, anticancer, antidiabetic, organ protective, and neuropharmacological activities. Moreover, the plant also has lipid-lowering, trypsin inhibitory, hemagglutinating, antiadhesive, and antifatigue activities. The fruit and seeds are well tolerated in humans and other animals. In conclusion, A. esculentus may be one of the best sources of pharmacologically active lead compounds. More research is necessary on its toxicogenetic effects in animals.

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“…It is urgent to seek an effective preventive measure to delay DKD. CHMs have been common in treating DM [37][38][39][40][41][42]and its complications [43][44][45], including DKD. In modern times, Many patients have turned to Chinese herbal medicine for treatment as a complementary and basic combinationdrug therapy for kidney disease in China due to its fewer adverse reactions and more effective interventions.…”

Section: Discussionmentioning

confidence: 99%

Chinese herbal medicine Tangshen Formula Treatment For Type 2 Diabetic Kidney Disease in Early Stage : study protocol for a randomized controlled trial

Jin

Huang

Meng

et al. 2019

Preprint

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Background: Diabetic kidney disease (DKD) is the main cause of end stage kidney disease(ESKD) and It has become a heavy economic and social burden due to its high prevalence and morbidity. However, the current therapies for DKD are not entirely perfect. The most effective strategy is that patients with DKD should be diagnosed and treated early. Preliminary studies showed the Chinese herbal Tangshen Formula(TSF) may delay the progression of DKD, reducing microand macro-albuminuria, improving renal function. This trial was conducted to assess the effectiveness and safety of TSF used in combination with conventional treatment. Methods/design: We are implementing a randomized, placebo-controlled, multicenter, clinical trial as a means of evaluating the effectiveness and safety of TSF. 623 participants will be randomized in a 1:1 ratio to an experiment group (TSF plus Losartan) and a control group (placebo plus Losartan). The trial cycle lasts 24 weeks. The primary outcome will be changes in ACR from baseline to 24 weeks between the two groups and ACR will be compared at baseline and treatment endpoint in each group. The secondary outcome will be changes in the ratio of progression into the clinical proteinuria period after intervention, Urine micro albumin negative conversion rate, the ratio of normal urinary micro albumin, doubling rate of baseline creatinine value and GFR between the two groups. Safety in medication will also be evaluated.Discussion: We hypothesize that type 2 diabetic patients in early stage of DKD will benefit from TSF. If successful, this study will provide an evidence-based complementary remedies for delaying the progression of DKD.Trial registration: ClinicalTrials.gov (NCT03009864)

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The Efficacy and Safety of the Chinese Herbal Formula, JTTZ, for the Treatment of Type 2 Diabetes with Obesity and Hyperlipidemia: A Multicenter Randomized, Positive-Controlled, Open-Label Clinical Trial

Cited by 27 publications

References 35 publications

Indian Morinda species: A review

Indian Morinda species: A review

Phytochemical information and pharmacological activities of Okra (Abelmoschus esculentus): A literature‐based review

Chinese herbal medicine Tangshen Formula Treatment For Type 2 Diabetic Kidney Disease in Early Stage : study protocol for a randomized controlled trial

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