The efficacy and safety of Banxia-Houpo-Tang for chronic pharyngitis

Xu, Chenyi; Yue, Rensong; Lv, Xuelian; Wu, Tingchao; Yang, Maoyi; Chen, Yuan

doi:10.1097/md.0000000000019922

Cited by 2 publications

(2 citation statements)

References 26 publications

(19 reference statements)

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“…The remission rate greater than or equal to 33.33% was efficient for total pharyngeal symptoms and signs. The remission rates of symptoms and signs were the ratio of the total score before treatment minus the total score after treatment to the total score before treatment ( Xu et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial

Wu,

Zhang,

Kuang

et al. 2024

Front. Pharmacol.

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Background: In clinical practice, antibiotics and/or inhaled or oral hormone preparations are the first line of treatment for chronic pharyngitis. However, this therapeutic regimen is not satisfactory enough. At present, medicinal plants as dietary supplements or functional foods are widely recognized for the treatment and prevention of different diseases.Purpose: This study aimed to evaluate the efficacy of the botanical lozenge made from several medicinal plant extracts in the treatment of chronic pharyngitis and its effects on patients’ illness perception and adherence to treatment.Methods: Patients with chronic pharyngitis were randomly assigned to the experimental group (n = 52) or the control group (n = 51). Patients were given botanical lozenges prepared from the extracts of medicinal plants such as Siraitia grosvenorii (Swingle) C. Jeffrey ex A.M.Lu and Zhi Y. Zhang [Cucurbitaceae; Siraitiae fructus], Lonicera japonica Thunb [Caprifoliaceae; Lonicerae japonicae flos], Platycodon grandiflorus (Jacq.) A. DC [Campanulaceae; Platycodon radix], and Glycyrrhiza uralensis Fisch. ex DC [Fabaceae; Glycyrrhizae radix et rhizoma] or placebos made of starch for 15 days. The improvement of pharyngeal symptoms and signs, illness perception, and adherence to treatment were evaluated at the end of the intervention.Results: The total score of pharyngeal symptoms of patients in the experimental group (3.33 ± 2.33) was significantly lower than that in the control group (5.20 ± 2.93) (p < 0.01). In comparison to the control group (3.43 ± 1.43), the total pharyngeal signs score of patients in the experimental group (2.69 ± 1.59) was considerably lower (p < 0.01). The improvement rates of pharyngeal itching, dry throat, pharyngeal foreign body sensation, aggravation due to excessive speaking, and congestion of pharyngeal mucosa in the experimental group were 73.81%, 67.50%, 67.57%, 65.22% and 44%, respectively, which were significantly higher than those in the control group (p < 0.05). In addition, patients taking botanical lozenges had better illness perception and adherence to treatment than those taking placebos (p < 0.05). Patients with low adherence to treatment showed less personal control, concerns, and understanding of chronic pharyngitis (p < 0.05).Conclusion: Botanical lozenges not only aided patients in recovering from chronic pharyngitis but also improved their positive perceptions of the disease, which helped them adhere to their treatment regimen.Clinical Trial Registration: [https://www.chictr.org.cn/], identifier [ChiCTR2200062139].

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Section: Methodsmentioning

confidence: 99%

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial

Wu,

Zhang,

Kuang

et al. 2024

Front. Pharmacol.

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“…Presently, anti-infective therapies are considered among the main methods for CP treatment [ 10 - 14 ]. Although these therapies can improve the condition, they are associated with several side effects, symptom recurrence, and late drug resistance and can only relieve short-term emergencies.…”

Section: Introductionmentioning

confidence: 99%

Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology

Fang,

Jiang,

Zhang

et al. 2024

CCHTS

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This study investigated the molecular action mechanism of a compound herb, also known as the Dendrobium officinale throat-clearing formula (QYF), by using network pharmacology and animal experimental validation methods to treat chronic pharyngitis (CP). The active ingredients and disease targets of QYF were determined by searching the Batman-TCM and GeneCards databases. Subsequently, the drug-active ingredient-target and protein-protein interaction networks were constructed, and the core targets were obtained through network topology. The Metascape database was screened, and the core targets were enriched with Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes. In total, 1403 and 241 potential targets for drugs and diseases, respectively, and 81 intersecting targets were yielded. The core targets included TNF, IL-6, and IL-1β, and the core pathways included PI3K-Akt. The QYF treatment group exhibited effectively improved general signs, enhanced anti-inflammatory ability in vitro, reduced serum and tissue expressions of TNF-α, IL-6, and IL-1β inflammatory factors, and decreased blood LPS levels and Myd88, TLR4, PI3K, Akt, and NF-κB p65 protein expression in the tissues. QYF could inhibit LPS production, which regulated the expression of the TLR4/PI3K/Akt/NF-κB signaling pathway to suppress the expression of the related inflammatory factors (i.e., TNF-α, IL-6, and IL-1β), thereby alleviating the CP process. background: With the increasing pressure of life, modern people often use hot pot, barbecue or drinking and other bad lifestyle to relieve anxiety. In long-term spicy food, drinking will stimulate the throat, causing CP.The treatment of CP using theories related to Chinese medicine has obvious advantages, such as less toxic side effects, mild and long-lasting curative effects, and appropriate treatment. other: This study's results will help further investigate the potential mechanisms of QYF in the treatment of CP.

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The efficacy and safety of Banxia-Houpo-Tang for chronic pharyngitis

Cited by 2 publications

References 26 publications

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial

Efficacy of botanical lozenges in the treatment of chronic pharyngitis: a randomized controlled trial

Exploring the Action Mechanism and Validation of the Key Pathways of Dendrobium officinale Throat-clearing Formula for the Treatment of Chronic Pharyngitis Based on Network Pharmacology

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