The Efficacy and Safety of Denosumab for Treating Giant Cell Tumor of Bone: A Systematic Review and Meta-Analysis

Abstract

Giant cell tumor of bone (GCTB) is a benign tumor of bone and is considered as a local aggressive tumor of bone. [1][2][3][4][5][6][7] The variation incidence of GCTB was reported between 1.03 and 1.66 per 1,000,000 popula-tion. 8 Among them, the mortality rate was 23%. 9 Currently, the management of GCTB was conflicting, and the surgical management is the widest treatment used, such as: wide resection and curratage. 4,[10][11][12] The wide