The Efficacy and Complications of Salvage Cryotherapy of the Prostate

Pisters, Louis L.; Eschenbach, Andrew C. von; Scott, Shellie M.; Swanson, David A.; Dinney, Colin P.N.; Pettaway, Curtis A.; Babaian, R. Joseph

doi:10.1016/s0022-5347(01)65084-5

Cited by 206 publications

(67 citation statements)

References 16 publications

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“…Reported results have been modest with the largest series of patients treated at MD Anderson Cancer Center. 80 Seventy-seven per cent of patients had negative sextant biopsies 6 months after cryoablation, but only 45 or 150 patients (31%) had persistently undetectable PSA with a mean follow-up for 13.5 months. A double freeze ± thaw cycle appeared to be more effective than a single cycle in reducing both positive post-treatment biopsy and biochemical failure rates.…”

Section: Recurrence After Radiation Therapymentioning

confidence: 92%

Local therapy for prostate-specific antigen recurrence after definitive treatment

Meng

Carroll

2001

Prostate Cancer Prostatic Dis

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Section: Recurrence After Radiation Therapymentioning

confidence: 92%

Local therapy for prostate-specific antigen recurrence after definitive treatment

Meng

Carroll

2001

Prostate Cancer Prostatic Dis

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“…Otras técnicas utilizables serían la braquiterapia, con SLE de 34% a 5 años aunque con menos efectos secundarios que la cirugía 31 . La crioterapia ofrece resultados controvertidos, que dependerían mucho del autor evaluado 32 . No existe evidencia científica de calidad significativa sobre la mejor terapia de rescate en la recidiva local post-RR.…”

Section: Riesgo Relacionado Cap Porcentaje Biopsias Negativasunclassified

Estado actual del ultrasonido de alta frecuencia (HIFU) en el tratamiento del adenocarcinoma prostático

García

Rascón

Amo

et al. 2007

Actas Urológicas Españolas

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RESUMENESTADO ACTUAL DEL ULTRASONIDO DE ALTA FRECUENCIA (HIFU) EN EL TRATAMIENTO DEL ADENOCARCINOMA PROSTÁTICO Objetivo. Evaluar el estado actual de la utilización del Ultrasonido de Alta Intensidad (HIFU) en el tratamiento del adenocarcinoma prostático (Cap).Método. Hemos llevado a cabo una revisión del papel actual del HIFU en el tratamiento del Cap.Resultados. La tecnología HIFU está actualmente siendo aplicada ya de forma habitual en Europa en el tratamiento del Cap. Las indicaciones principales en la actualidad son dos: la aplicación del HIFU como primer escalón terapéutico y como terapia de rescate en recidivas post-radioterapia. Los trabajos actuales están basados en equipos clínicos en desarrollo. Aunque las últimas publicaciones sugieren que HIFU es una forma de tratamiento útil para el Cap bien y moderadamente diferenciado, existe todavía falta de comparaciones de esta terapia menos invasiva con los tratamientos estándar. Seguimos detectando en los trabajos disparidad en la definición de supervivencia libre de enfermedad (SLE), lo que dificulta la interpretación de resultados y la extracción de conclusiones definitivas.Conclusiones. La experiencia de los grupos de trabajo especializados en HIFU es altamente prometedora. Entre los aspectos a destacar está su gran capacidad de destrucción tumoral local tanto en los casos primarios como en las recidivas post-radioterapia. Para extraer conclusiones a medio y largo plazo debemos generar ensayos clí-nicos randomizados y controlados con seguimiento suficiente para medir beneficios en términos de supervivencia global y calidad de vida (balance efectos adversos / beneficios), realizar comparaciones con las terapias estándar y homogeneizar los criterios de definición de la SLE.Palabras clave: Ultrasonido de alta frecuencia (HIFU). Adenocarcinoma prostático. ABSTRACT CURRENT STATE OF HIGH INTENSITY FOCUSED ULTRASOUND (HIFU) AS TREATMENT OF PROSTATICCARCINOMA Objective. To evaluate the current state of high intensity focused ultrasound as therapeutical option of prostatic carcinoma (PCa) Methods. We completed an extense review of urologic literature on the role of HIFU on the treatment of PCa.Results. This technique is nowadays usually being indicated in Europe as treatment of many cases of either primary or relapsed PCa after radiotherapy. Although some reports suggest that HIFU is very effective as treatment for low and medium risk localized PCa patients, no randomized series comparing this technique with conventional therapies have been presented yet. Great disparity in criteria to define free-disease survival is detected, which make difficult the interpretation of results.Conclusions. Experience of some groups in HIFU is highly promising. Local tumour destruction is evident both in primary and relapsed PCa cases. To make conclusions in the long-term, controlled-randomized trials must be designed, with follow-up to measure benefits in global survival and quality of live. Comparisons must be completed with conventional techniques, and a uniform definition of dis...

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“…Complications associated with salvage cryotherapy are higher than primary cases. 26,27 The tissues surrounding the prostate are likely to have poor vascular circulation and hence limited healing abilities post radiotherapy. 28 Therefore, freezing must be stopped once the leading edge of the iceball has reached the capsule of the prostate.…”

Section: Technical Considerations Of Salvage Cryoablationmentioning

confidence: 99%

Salvage cryosurgery for locally recurrent prostate cancer following radiotherapy

Ahmed

Lindsey

Davies

2004

Prostate Cancer Prostatic Dis

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The Efficacy and Complications of Salvage Cryotherapy of the Prostate

Abstract: Salvage cryotherapy impacts local tumor control as evident by the high frequency of negative posttreatment biopsies. A double freeze-thaw cycle appears more effective than a single cycle. Like salvage prostatectomy, salvage cryotherapy causes significant morbidity.

Cited by 206 publications

References 16 publications

Local therapy for prostate-specific antigen recurrence after definitive treatment

Local therapy for prostate-specific antigen recurrence after definitive treatment

Estado actual del ultrasonido de alta frecuencia (HIFU) en el tratamiento del adenocarcinoma prostático

Salvage cryosurgery for locally recurrent prostate cancer following radiotherapy

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