The Effects on the Pain of Infiltration Anesthesia at the Canine Mucobuccal Region by Different Concentrations of Topical Anesthesia

Ishii, Toshiharu; Nakanishi, Osamu; Fujimoto, Atsuhito; Shimizu, Eiji; Yamamuro, Tsukasa; Fukui, Ikuto; Kou, Fusaji; Fuushuku, Hirotaka; Koba, Hirotaka; Horiuchi, Nobuko; Nishi, Masakatsu

doi:10.2504/kds.49.533

J Kyushu Dent Soc

1995

DOI: 10.2504/kds.49.533

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The Effects on the Pain of Infiltration Anesthesia at the Canine Mucobuccal Region by Different Concentrations of Topical Anesthesia

Toshiharu Ishii¹,

Osamu Nakanishi²,

Atsuhito Fujimoto³

et al.

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“…Regarding the analgesic effects of topical anesthetics for the oral cavity, evaluation using not only VAS 1,[3][4][5] but also based on the depth of injection needle insertion 6) have been reported.…”

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confidence: 99%

Development and Clinical Evaluation of New Topical Anesthetic Formulations for Dental Care

Ando

Shimoo²,

Nakasato³

et al. 2016

Biological & Pharmaceutical Bulletin

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To provide safe dental care, it is important to minimize the pain associated with the initial injection of the local anesthetic. For this purpose, a topical anesthetic is preliminarily applied to the area where a needle will be inserted in a clinical setting. In this study, we prepared new topical anesthetic formulations with favorable intra-oral retentivity and an excellent anesthetic effect, and clinically evaluated their efficacy. We used 4% lidocaine solution as an anesthetic drug and gelatin, agar, and a food thickener as a base to prepare new topical anesthetic formulations. The subjects rested in a supine position on a chair for dental practice prior to the following experiments. Firstly, about 0.2 g of the sample was applied at a test site. One minute later, the sample was removed, and a 30 G dental injection needle was inserted into the test site. The agar/ gelatin-based formulation containing gelatin of 2% and agar of 1% had a moderate solidity at 25°C and a moderate fluidity at 37°C. This formulation showed a significantly greater depth than any of the commercially available topical anesthetics. The results of the present study demonstrated that the agar/gelatin-based formulation showed an excellent analgesic effect against pain associated with needle insertion.

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mentioning

confidence: 99%

Development and Clinical Evaluation of New Topical Anesthetic Formulations for Dental Care

Ando

Shimoo²,

Nakasato³

et al. 2016

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

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The Effects on the Pain of Infiltration Anesthesia at the Canine Mucobuccal Region by Different Concentrations of Topical Anesthesia

Cited by 1 publication

References 1 publication

Development and Clinical Evaluation of New Topical Anesthetic Formulations for Dental Care

Development and Clinical Evaluation of New Topical Anesthetic Formulations for Dental Care

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