The effects of β₂ adrenoceptor gene polymorphisms 
on pressor response during laryngoscopy and tracheal intubation

Abstract

We investigated whether human beta2 adrenoceptor (beta2AR) gene polymorphisms are associated with the pressor response to laryngoscopy and tracheal intubation. Ninety-two patients undergoing elective surgery under general anaesthesia were enrolled into this study. Arterial systolic pressure, heart rate and rate pressure product were measured before induction of anaesthesia and 1 min following laryngoscopy and tracheal intubation. Genomic DNA was then used to identify the beta2AR-16 and beta2AR-27 genes using an allele-specific polymerase chain reaction method. Using multiple linear regression models, controlling for age, sex, weight, baseline blood pressure, heart rate and rate pressure product, we found that patients who possessed the glutamic acid homozygote of beta2AR-27 produced significantly greater changes in mean arterial pressure and rate pressure products than patients with the glutamine homozygote of beta2AR-27 (beta coefficient for mean blood pressure = 11.81, beta coefficient for pulse-pressure product = 8.76, both p-values = 0.023). These findings suggest that genetic variability in the human beta2AR gene polymorphisms may be associated with the pressor response to laryngoscopy and tracheal intubation.

β2 Adrenoceptor (ADRB2) Pharmacogenetics and Cardiovascular Phenotypes during Laryngoscopy and Tracheal Intubation

“…KAYMAK ET AL. laryngoscopy and tracheal intubation were investigated only in a previous study by Kim et al (2002). They found an association between changes of MAP and RPP and Glu27Glu (mutant) as compared with the Gln27Gln (wild-type) genotype.…”

Attenuation of hemodynamic responses to laryngoscopy and endotracheal intubation by intravenous esmolol

“…This increase in blood pressure and heart rate are usually transitory, variable and unpredictable. Transitory hypertension and tachycardia are probably of no consequence in healthy individuals, 14 but either or both may be hazardous to those with history of diabetes, preeclampsia, myocardial insufficiency or cerebrovascular diseases. 15,16 This sympathoadrenal response to laryngoscopy results in an increased cardiac work load which in turn may culminate in perioperative myocardial ischemia and acute heart failure in susceptible individuals.…”

Oral Clonidine Premedication: A Comparative Study With a Placebo in Attenuating Hemodynamic Responses to Laryngoscopy and Intubation

“…Transitory hypertension and tacdrycardia are probably of no consequence in healthy individuals. 10 But either or both may be hazardous to those with pre-ecclampsia, myocardial insufficiency or cerebrovascular diseases. 11 This sympatho adrenal responses to laryngoscopy results in an increased cardiac work load which in turn may culminate in preoperative myocardial ischemia and acute heart failure in susceptible individuals.…”