The Effects of α2-Adrenergic Receptor Agonist Dexmedetomidine on Hemodynamic Response in Direct Laryngoscopy

Işık, Berrin; Arslan, Mustafa; Ozsoylar, Ozgur; Akçabay, Mehmet

doi:10.2174/1874428100701010005

Cited by 10 publications

(4 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In our study the mean SBP, mean DBP, mean MAP decreased in both the study groups after premedication (Table no. 6,7,8). There was statistically significant reduction in systolic and diastolic blood pressure and mean arterial blood pressure in group A as compared to group B at 5, 10, 15, 20, 25 and 30 min after premedication (p value < 0.05).In our study, peripheral arterial SpO2 and RR were compared in both groups (Table no.…”

Section: Anxiety Score:-mentioning

confidence: 51%

Comparison of Intranasal Dexmedetomidine v/S Midazolam as a Premedication in Chidren With Congenital Heart Disease Undergoing Cardiac Surgery

Morwal¹,

Singh²,

Vyas³

et al. 2021

IJAR

View full text Add to dashboard Cite

Background: The intranasal route is a reliable way to administer preanaesthetics and sedatives to children. The aim of present study was to compare the anxiolytic and sedative effects of intranasal dexemedetomidine and midazolam as a premedication in children with congenital heart disease undergoing cardiac surgery.. Patients and Methods: Fifty chidrens 2-12 years of age group of either sex with congenital heart disease undergoing cardiac surgery were randomly allocated into two groups. Group A-(n=25) - received intranasal dexmedetomidine as premedication.(0.1 Ã‚Âµg/kg diluted in 2ml NS ) Group B- (n=25)- received intranasal midazolam as premedication. (0.2 mg/kg diluted in 2ml NS) Heart rate, mean arterial blood pressure and oxygen saturation were monitored upto30 minute after drug administration. The sedation score, anxiety score and child separation score were recorded until the child taken to the OR. The postoperative agitation score was also observed. Results and Conclusion: Premedication with intranasal dexmedetomidine attained significant and satisfactory sedation with better parental separation and lower anxiety levels without any adverse effects as compared with intranasal midazolam in children with congenital heart disease undergoing cardiac surgery.

show abstract

Section: Anxiety Score:-mentioning

confidence: 51%

Comparison of Intranasal Dexmedetomidine v/S Midazolam as a Premedication in Chidren With Congenital Heart Disease Undergoing Cardiac Surgery

Morwal¹,

Singh²,

Vyas³

et al. 2021

IJAR

View full text Add to dashboard Cite

show abstract

“…The main disadvantage of IV dexmedetomidine is that sedative action is more pronounced than analgesic effect with profound bradycardia and hypotension [ 18 ]. Moreover, rapid IV dexmedetomidine infusion may cause biphasic alteration of MAP, which is undesirable in anesthesia [ 17 , 19 ]. To minimize these adverse effects, alternative routes of dexmedetomidine were under trial.…”

Section: Discussionmentioning

confidence: 99%

Nebulized Versus Intravenously Administered Dexmedetomidine for Obtunding Hemodynamic Responses to Laryngoscopy and Tracheal Intubation: A Randomized Double-Blind Comparative Study

Singla,

Saraswat,

Bharadwaj

et al. 2024

Cureus

View full text Add to dashboard Cite

Introduction Intravenous dexmedetomidine is known to cause major adverse effects such as bradycardia, hypotension, cardiac arrhythmias, and heart block when used as premedication for attenuation of the laryngoscopy and intubation response, limiting its routine use. Thus, it is important to study other routes of administration of dexmedetomidine. Objectives To compare the hemodynamic response and sedation score between intravenous and nebulized dexmedetomidine as premedication for the attenuation of the laryngoscopy and intubation response. Materials and methods In this study, 60 patients fulfilling inclusion criteria undergoing surgeries under general anesthesia (ASA Grade I and II) were randomly allocated into two groups of 30 patients each. Group IV received intravenous 1 mcg/kg dexmedetomidine in 100 mL normal saline, and Group IN received nebulization with 1 mcg/kg dexmedetomidine diluted to a total volume of 5 cc of normal saline, 30 minutes prior to the induction of general anesthesia. Sedation scores were calculated using the Ramsay sedation score at 20 minutes after the administration of the drug; patients were induced by the standard protocol, and laryngoscopy was performed. Vitals were recorded before the administration of the drug and after intubation at stipulated time intervals. Results The median heart rate becomes significantly lower at 15 minutes (70 vs. 76.5) and 20 minutes (66 vs. 76) after induction among Group IV as compared to Group IN. The median systolic blood pressure was significantly lower at 20 minutes in Group IV (110 mmHg) than in Group IN (119 mmHg). The median diastolic blood pressure was significantly lower at 10 minutes (76 vs. 79), 15 minutes (70 vs. 77), and 20 minutes (69 vs. 78.5) in Group IV than in Group IN. The median of mean arterial pressure was significantly lower at 15 minutes (84.8 vs. 91.5) and 20 minutes (83 vs. 92) in Group IV than in Group IN. A comparison of vitals after induction shows that the median heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure were significantly lower statistically among Group IV as compared to Group IN at 0, 1, 3, 5, 10, 15, and 30 minutes after induction (except for systolic blood pressure at 3 minutes). The median sedation score was lower in Group IN (0) than in Group IV (1); this difference is statistically significant. Conclusion The obtundation of hemodynamic responses following laryngoscopy and maintaining hemodynamics intraoperatively is statistically better with nebulized dexmedetomidine compared to intravenous dexmedetomidine.

show abstract

“…30 Berrin et al 2007 and Turan et al 2008 have similarly shown the advantageous effects of Dexmedetomidine during intubation and extubation respectively. 31,32 Hsu YW et al 2004 elicited that Dexmedetomidine, at 0.6-1.2 ng/ml plasma concentration, simulated natural sleep with intact hypercapnic ventilatory response, significant reduction in apnoea-hypopnoea index with intact hypercapnic arousal phenomenon; thereby, changes in paCO 2 and minute ventilation was found comparable to baseline. 33 Yacout AG et al 2012 assessed recovery profile by measuring tracheal extubation time, time to eye opening and time to following verbal commands which were longer in group D relative to group P but with no statistically significant difference between both groups.…”

Section: Bi Spectral Index Monitormentioning

confidence: 99%

Effect of dexmedetomidine infusion on stress induced blood glucose levels and intraoperative sevoflurane requirement

Kameshwar¹,

Upadhyay²

2020

IJCA

View full text Add to dashboard Cite

Introduction: Dexmedetomidine has been shown to blunt the stress response to surgery and reduce the consumption of inhalational anaesthetic agents. Hence, we designed this study to observe the effects of IV Dexmedetomidine infusion on stressinduced blood glucose levels and intra operative Sevoflurane requirement during laparoscopic surgery. Materials and Methods: Sixty patients between the ages of 18-60 years, of either gender, ASA Grade I & II, posted for elective laparoscopic surgical procedures under general anaesthesia were divided into two groups of 30 each. Group D received loading dose of Inj. Dexmedetomidine at 1µg/kg diluted to 50 ml and given over 10 minutes; followed by maintenance with 0.5µg/kg/hour, till the end of surgery. Group P received similar volume of normal saline. Anaesthesia was maintained with Nitrous oxide in oxygen (50:50) and Sevoflurane keeping BIS 40 -60. Serial blood glucose levels, sevoflurane requirement by Dion's method, extubation time, sedation score and adverse effects were observed. The data was analyzed using student t test.Results: Blood glucose levels at first hour post operatively in group P and in group D, were 136.7±6.30 mg/dl and 103.8±8.28 mg/dl respectively (P<0.0001). There was 27.07% rise in group P and 2.89% fall in group D from baseline value. Mean first hourly Sevoflurane consumption in group P and in group D were 11.22±1.14 ml and 8.34±0.88 ml respectively (p<0.0001) (25.61% reduction in group D). Conclusion: IV Dexmedetomidine infusion was effective in attenuating stress induced blood glucose levels and it also reduced Sevoflurane requirement without affecting the time for extubation.

show abstract

The Effects of α2-Adrenergic Receptor Agonist Dexmedetomidine on Hemodynamic Response in Direct Laryngoscopy

Cited by 10 publications

References 21 publications

Comparison of Intranasal Dexmedetomidine v/S Midazolam as a Premedication in Chidren With Congenital Heart Disease Undergoing Cardiac Surgery

Comparison of Intranasal Dexmedetomidine v/S Midazolam as a Premedication in Chidren With Congenital Heart Disease Undergoing Cardiac Surgery

Nebulized Versus Intravenously Administered Dexmedetomidine for Obtunding Hemodynamic Responses to Laryngoscopy and Tracheal Intubation: A Randomized Double-Blind Comparative Study

Effect of dexmedetomidine infusion on stress induced blood glucose levels and intraoperative sevoflurane requirement

Contact Info

Product

Resources

About