The effects of α‐methyldopa on myometrial noradrenaline release and myometrial contractility in rat

Abstract

Our experimental data suggest that besides its antihypertensive effect, alpha-methyldopa may influence the adrenergic transmission of the pregnant uterus. Our results indicate that the agent decreases the efficacy of beta(2)-adrenergic agonists at term pregnancy and increases the response to alpha-sympathomimetics in early pregnancy.

Effects of Maternal Alpha Methyldopa Administration on Memory of Rat Offspring during Growing Age

“…The current study was performed to evaluate the effect of prenatal exposure to the alpha methyldopa, a classic anti-hypertensive drug severally used in pregnant mother, on the memory of children during growing age in the rat [1][2][3]. For the assessment of memory we used the object recognition task which is a stress-less and reliable task for the evaluation of spatial memory [15,16].…”

“…Alpha-Methyldopa (AMD) is a classic antihypertensive agent used in the treatment of hypertensive crisis [1]. In some countries, including United States and United Kingdom, the AMD is the first line on the treatment of pregnancy hypertension and commonly used in the pregnant women [2,3].…”

The effects of experimental diabetes mellitus on the adrenergic functions of the rat uterus

“…This remodeling involves a profound denervation procedure in which the histologically visualized density of these nerves decreases substantially, as the pregnancy continues. According to our previous superfusion studies, adrenergic denervation regarding the uterine contractile functions can be detected, as early as at the 7 th day of pregnancy in the rat [48]. However the morphological degeneration of the axons only becomes evident at day 15 of pregnancy, detected by hystochemical characterization [49].…”