The effects of zinc treatment on matrix metalloproteinases: A systematic review

Nosrati, Rahmat; Kheirouri, Sorayya; Ghodsi, Ramin; Ojaghi, Habib

doi:10.1016/j.jtemb.2019.08.001

Cited by 35 publications

(17 citation statements)

References 78 publications

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“…After zinc doping, the amount of VEGF released from the endothelial cells on the TiO 2 nanotubes surface increased further because the matrix metalloproteinase (MMP) in endothelial cells is a kind of extracellular protein hydrolase with zinc ions and calcium ions dependence. It can promote the release of VEGF from the endothelial cells, thus enhancing the adhesion and proliferation of endothelial cells . Because more zinc ions are released from the surface of TNT-50Zn, they can promote the synthesis of MMP and further release more VEGF.…”

Section: Results and Discussionmentioning

confidence: 99%

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Pan

Gong

et al. 2020

ACS Biomater. Sci. Eng.

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Titanium dioxide nanotube arrays are widely used in biomaterials due to their unique tubular structure and tunable biocompatibility. In the present study, titanium oxide nanotube arrays with different diameters were prepared on the titanium surface by anodization, followed by zinc doping using hydrothermal treatment to enhance the biocompatibility. Both the nanotube dimensions and zinc doping had obvious influences on the hydrophilicity, protein adsorption, blood compatibility, and endothelial cell behaviors of the titanium surface. The increase of the diameter and zinc doping can improve the hydrophilicity of the titanium surface. The increase of nanotube diameter could reduce the albumin adsorption while increasing the fibrinogen adsorption. However, zinc doping can simultaneously promote the adsorption of albumin and fibrinogen, and the effect was more obvious for albumin. Zinc doping can significantly improve the blood compatibility of the titanium oxide nanotubes because it cannot only increase the activity of cyclophosphate guanylate (cGMP) but also significantly reduce the platelets adhesion and hemolysis rate. Moreover, it was also found that both the smaller diameter and zinc doping nanotubes can enhance the endothelial cell adhesion and proliferation as well as up-regulate the expression of NO and VEGF. Therefore, the zinc doped titanium dioxide nanotube array can be used to simultaneously improve the blood compatibility and promote endothelialization of the titanium-based biomaterials and implants, such as intravascular stents.

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Section: Results and Discussionmentioning

confidence: 99%

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Pan

Gong

et al. 2020

ACS Biomater. Sci. Eng.

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“…The degradation rate of implanted TM-doped cryogels was in the order: Zn > Cu > Co ≥ Ctrl ( Figure 8 , 1 ). The profound promoting effect of the Zn dopant is apparently associated with this TM activity as a key cofactor of different MMPs, including MMP-1, MMP-3, MMP-8, MMP-13, MMP-2, and MMP-9 [ 75 ]. The peptidase activity of MMP-1 and MMP-9 can be also promoted by Cu [ 38 ] in accordance with some lesser effect of the latter dopant.…”

Section: Discussionmentioning

confidence: 99%

Regenerative Activities of ROS-Modulating Trace Metals in Subcutaneously Implanted Biodegradable Cryogel

Yergeshov

Zoughaib

Ishkaeva

et al. 2022

Gels

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Divalent trace metals (TM), especially copper (Cu), cobalt (Co) and zinc (Zn), are recognized as essential microelements for tissue homeostasis and regeneration. To achieve a balance between therapeutic activity and safety of administered TMs, effective gel formulations of TMs with elucidated regenerative mechanisms are required. We studied in vitro and in vivo effects of biodegradable macroporous cryogels doped with Cu, Co or Zn in a controllable manner. The extracellular ROS generation by metal dopants was assessed and compared with the intracellular effect of soluble TMs. The stimulating ability of TMs in the cryogels for cell proliferation, differentiation and cytokine/growth factor biosynthesis was characterized using HSF and HUVEC primary human cells. Multiple responses of host tissues to the TM-doped cryogels upon subcutaneous implantation were characterized taking into account the rate of biodegradation, production of HIF-1α/matrix metalloproteinases and the appearance of immune cells. Cu and Zn dopants did not disturb the intact skin organization while inducing specific stimulating effects on different skin structures, including vasculature, whereas Co dopant caused a significant reorganization of skin layers, the appearance of multinucleated giant cells, along with intense angiogenesis in the dermis. The results specify and compare the prooxidant and regenerative potential of Cu, Co and Zn-doped biodegradable cryogels and are of particular interest for the development of advanced bioinductive hydrogel materials for controlling angiogenesis and soft tissue growth.

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“…In addition, bioactive compounds that are more rapidly released can diffuse through the extracellular fluid helping cell proliferation and matrix formation [ 60 , 61 ]. The presence of Zn 2+ in the extracellular environment has been related to the activation of matrix metalloproteases responsible for the degradation of the cartilage matrix by proteolysis and is closely related to osteoarthritis mechanisms [ 41 , 62 ]. However, there is a therapeutic concentration range of Zn 2+ (0.015 to 6.5 μg/mL) in which this element can have the opposite effect inhibiting the activity of these enzymes [ 63 ].…”

Section: Discussionmentioning

confidence: 99%

Biomimetic Gradient Scaffolds Containing Hyaluronic Acid and Sr/Zn Folates for Osteochondral Tissue Engineering

et al. 2021

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Regenerative therapies based on tissue engineering are becoming the most promising alternative for the treatment of osteoarthritis and rheumatoid arthritis. However, regeneration of full-thickness articular osteochondral defects that reproduces the complexity of native cartilage and osteochondral interface still remains challenging. Hence, in this work, we present the fabrication, physic-chemical characterization, and in vitro and in vivo evaluation of biomimetic hierarchical scaffolds that mimic both the spatial organization and composition of cartilage and the osteochondral interface. The scaffold is composed of a composite porous support obtained by cryopolymerization of poly(ethylene glycol) dimethacrylate (PEGDMA) in the presence of biodegradable poly(D,L-lactide-co-glycolide) (PLGA), bioactive tricalcium phosphate β-TCP and the bone promoting strontium folate (SrFO), with a gradient biomimetic photo-polymerized methacrylated hyaluronic acid (HAMA) based hydrogel containing the bioactive zinc folic acid derivative (ZnFO). Microscopical analysis of hierarchical scaffolds showed an open interconnected porous open microstructure and the in vitro behaviour results indicated high swelling capacity with a sustained degradation rate. In vitro release studies during 3 weeks indicated the sustained leaching of bioactive compounds, i.e., Sr2+, Zn2+ and folic acid, within a biologically active range without negative effects on human osteoblast cells (hOBs) and human articular cartilage cells (hACs) cultures. In vitro co-cultures of hOBs and hACs revealed guided cell colonization and proliferation according to the matrix microstructure and composition. In vivo rabbit-condyle experiments in a critical-sized defect model showed the ability of the biomimetic scaffold to promote the regeneration of cartilage-like tissue over the scaffold and neoformation of osteochondral tissue.

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The effects of zinc treatment on matrix metalloproteinases: A systematic review

Cited by 35 publications

References 78 publications

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Improved Blood Compatibility and Endothelialization of Titanium Oxide Nanotube Arrays on Titanium Surface by Zinc Doping

Regenerative Activities of ROS-Modulating Trace Metals in Subcutaneously Implanted Biodegradable Cryogel

Biomimetic Gradient Scaffolds Containing Hyaluronic Acid and Sr/Zn Folates for Osteochondral Tissue Engineering

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