The effects of zinc supplementation on metabolic profile and oxidative stress in overweight/obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

Fathi, Mojdeh; Alavine­jad, Pezhman; Haidari, Zahra; Amani, Reza

doi:10.1016/j.jtemb.2020.126635

Cited by 28 publications

(18 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease with 24.4% prevalence worldwide, with 20−30% dominance in Western countries, and 5−18% in Asian countries. NAFLD is a multifactorial disease with complex pathophysiology such as obesity (80% of obese individuals present NAFLD), insulin resistance (IR), dyslipidemia and metabolic syndrome [96,97]. Recently, it was shown that COVID-19 patients with NAFLD have increased risk of COVID-19 disease progression, underlined by an abnormal liver function, and by a longer period of viral shedding in comparison with non-NAFLD individuals [98].…”

Section: Zinc In the Therapy Of Non-alcoholic Liver Disease (Nafld)mentioning

confidence: 99%

“…In addition, zinc regulates secretion, receptor activation and signal transduction of insulin [111], thus zinc deficiency may influence insulin resistance and diabetes mellitus [112]. The recent studies by Fathi et al [97] showed that 3-month therapy with 30 mg elemental zinc supplement improves serum levels of insulin, insulin resistance, superoxide dismutase 1 (SOD1) and malondialdehyde (MDA), thus improving stress status in overweight/obese NAFLD patients.…”

Section: Zinc In the Therapy Of Non-alcoholic Liver Disease (Nafld)mentioning

confidence: 99%

See 1 more Smart Citation

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

et al. 2021

View full text Add to dashboard Cite

Zinc is the second most abundant trace element in the human body, and it plays a fundamental role in human physiology, being an integral component of hundreds of enzymes and transcription factors. The discovery that zinc atoms may compete with copper for their absorption in the gastrointestinal tract let to introduce zinc in the therapy of Wilson’s disease, a congenital disorder of copper metabolism characterized by a systemic copper storage. Nowadays, zinc salts are considered one of the best therapeutic approach in patients affected by Wilson’s disease. On the basis of the similarities, at histological level, between Wilson’s disease and non-alcoholic liver disease, zinc has been successfully introduced in the therapy of non-alcoholic liver disease, with positive effects both on insulin resistance and oxidative stress. Recently, zinc deficiency has been indicated as a possible factor responsible for the susceptibility of elderly patients to undergo infection by SARS-CoV-2, the coronavirus responsible for the COVID-19 pandemic. Here, we present the data correlating zinc deficiency with the insurgence and progression of Covid-19 with low zinc levels associated with severe disease states. Finally, the relevance of zinc supplementation in aged people at risk for SARS-CoV-2 is underlined, with the aim that the zinc-based drug, classically used in the treatment of copper overload, might be recorded as one of the tools reducing the mortality of COVID-19, particularly in elderly people.

show abstract

Section: Zinc In the Therapy Of Non-alcoholic Liver Disease (Nafld)mentioning

confidence: 99%

Section: Zinc In the Therapy Of Non-alcoholic Liver Disease (Nafld)mentioning

confidence: 99%

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Compared to the placebo arm, zinc supplementation reduced fasting blood sugar and improved oxidative stress markers, highlighting the systemic metabolic impacts of micronutrients. 197 Sprague-Dawley rats fed a high-fat diet for 20 weeks exhibited NAFLD-like features, including hepatic steatosis and elevated fasting blood sugar compared with control counterparts. Cosupplementation with zinc and selenium during the final 8 weeks of the study significantly reduced these features.…”

Section: Supplementary Materialsmentioning

confidence: 96%

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

et al. 2022

View full text Add to dashboard Cite

“…This includes reductions in ammonia levels, improvement of glucose tolerance, decrease in insulin resistance, stimulation of liver regeneration [109,110], and several hepatoprotective effects, e.g., induction of metallothionein synthesis; improvement of protein synthesis in the liver; inhibition of lipid peroxidation; anti-oxidative effects against cellular, mitochondrial, and ER stress; and anti-inflammatory effects [111]. In a recent study on the effects of a 3-month course of zinc supplementation (30 mg elemental Zn) on metabolic profile and oxidative stress in obese patients with non-alcoholic fatty liver disease (NAFLD), Fathi et al [112] demonstrated improvement of insulin resistance and oxidative stress. Lipid profiles and weight were not affected.…”

Section: Zinc Supplementation In Liver Diseasementioning

confidence: 99%

Albumin Substitution in Decompensated Liver Cirrhosis: Don’t Forget Zinc

et al. 2021

View full text Add to dashboard Cite

Decompensated liver cirrhosis has a dismal prognosis, with patients surviving on average for 2–4 years after the first diagnosis of ascites. Albumin is an important tool in the therapy of cirrhotic ascites. By virtue of its oncotic properties, it reduces the risk of cardiovascular dysfunction after paracentesis. Treatment with albumin also counteracts the development of hepatorenal syndrome and spontaneous bacterial peritonitis. More recently, the positive impact of long-term albumin supplementation in liver disease, based on its pleiotropic non-oncotic activities, has been recognized. These include transport of endo- and exogenous substances, anti-inflammatory, antioxidant and immunomodulatory activities, and stabilizing effects on the endothelium. Besides the growing recognition that effective albumin therapy requires adjustment of the plasma level to normal physiological values, the search for substances with adjuvant activities is becoming increasingly important. More than 75% of patients with decompensated liver cirrhosis do not only present with hypoalbuminemia but also with zinc deficiency. There is a close relationship between albumin and the essential trace element zinc. First and foremost, albumin is the main carrier of zinc in plasma, and is hence critical for systemic distribution of zinc. In this review, we discuss important functions of albumin in the context of metabolic, immunological, oxidative, transport, and distribution processes, alongside crucial functions and effects of zinc and their mutual dependencies. In particular, we focus on the major role of chronic inflammatory processes in pathogenesis and progression of liver cirrhosis and how albumin therapy and zinc supplementation may affect these processes.

show abstract

The effects of zinc supplementation on metabolic profile and oxidative stress in overweight/obese patients with non-alcoholic fatty liver disease: A randomized, double-blind, placebo-controlled trial

Cited by 28 publications

References 50 publications

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury

Nonalcoholic Fatty Liver Disease and the Gut-Liver Axis: Exploring an Undernutrition Perspective

Albumin Substitution in Decompensated Liver Cirrhosis: Don’t Forget Zinc

Contact Info

Product

Resources

About