The effects of Zinc-Methionine on glucose metabolism and insulin resistance during late pregnancy in ewes

Sadegzadeh-Sadat, M.; Anassori, Ehsan; Khalilvandi-Behroozyar, Hamed; Asri‐Rezaei, Siamak

doi:10.1016/j.domaniend.2021.106647

Cited by 5 publications

(3 citation statements)

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“…Decreased insulin sensitivity is observed at different life stages and is physiological at puberty, ageing, and pregnancy (Duehlmeier et al 2013;Brondani et al 2016;Sadegzadeh-Sadat et al 2021). A complex endocrine-metabolic adaptation occurs during pregnancy involving changes in insulin sensitivity, increased β cell mass response, slight elevation of blood glucose after feeding (Duehlmeier et al 2013), and changes in circulating levels of phospholipids, free fatty acids, triglycerides, and cholesterol (Santarosa et al 2019a).…”

Section: Discussionmentioning

confidence: 99%

“…In addition to insulin and glucagon (insulin-antagonist), somatotropic axis hormones, including the growth hormone, IGF-1, and thyroid hormones (T3 and T4), are the major determinants of basal metabolism, and the deposition or secretion of nutrients (Schmitt et al 2012;Sadegzadeh-Sadat et al 2021). The homeostatic model assessment for IR (HOMA IR) (Kalyesubula et al 2020) and β-cell activity (HOMA β) were developed to evaluate insulin sensitivity and β-cell activity, respectively, using only insulinemia and blood glucose values after fasting because insulin and glucose concentrations at the basal state are determined by feedback (Vasques et al 2008).…”

Section: Introductionmentioning

confidence: 99%

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Endocrine-metabolic Adaptations in Dorper Ewes: Comparison Between Single and Twin Pregnancies During Gestation, Delivery, and Postpartum

Santarosa

Ferreira

Hooper

et al. 2021

Preprint

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The present study involved a blood glucose, hormonal profile, and insulin resistance evaluation in sheep from conception until 48 h postpartum. A total of 60 healthy Dorper ewes, raised under semi-intensive management were included in the study. Two experimental groups were applied: G1, single pregnancy (n = 30) and G2, twin pregnancy (n = 30). The experimental time points were immediately after fixed-time artificial insemination; at 30 d, 90 d, 120 d, 130 d, and 140 d of pregnancy; on the delivery day (DD); and at 24 h (PD1) and 48 h (PD2) postpartum. Blood samples were taken to analyse glucose, insulin, glucagon, cortisol, thyroid hormones (T3 and T4) levels. All parameters showed significant differences over the analysed sample times; however, only cortisol showed differences within groups, with the G1 having higher values than the G2 group. The interaction of the groups in the nine sample times showed a significant result (P = 0.001) only for glucagon. The number of foetuses directly interfered with the glucagon profile throughout gestation and insulin concentration postpartum. The glucose, cortisol, insulin, glucagon, and HOMA IR concentrations increased at DD and decreased at PD1 and PD2. T3 and T4 levels increased at DD. Despite the changes found in the endocrine system and metabolism in Dorper ewes throughout pregnancy, the nutritional management ensured a healthy status during pregnancy, delivery, and postpartum.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endocrine-metabolic Adaptations in Dorper Ewes: Comparison Between Single and Twin Pregnancies During Gestation, Delivery, and Postpartum

Santarosa

Ferreira

Hooper

et al. 2021

Preprint

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show abstract

“…Previously, expression of key proteins related to fatty acid transport, fatty acid oxidation and glycolysis/gluconeogenesis were suppressed when dietary Met deficiency, which were ameliorated by feeding diets with adequate Met [ 20 ]. Compared with low dietary Met, high Met supplement enhanced the mRNA levels of hepatic gluconeogenesis related genes such as phosphoenolpyruvate carboxykinase and glucose-6-phosphatase [ 42 ], which was effective in improving energy metabolisms in late pregnant ewes [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of supplementing lysins and methionine to low-protein diets on growth performance, hepatic antioxidant capacity, immune status, and glycolytic activity of tibetan sheep

Ji,

Zhang,

et al. 2024

BMC Genomics

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Reducing the levels of dietary protein is an effective nutritional approach in lowering feed cost and nitrogen emissions in ruminants. The purpose of this study was to evaluate the effects of dietary Lys/Met ratio in a low protein diet (10%, dry matter basis) on the growth performance and hepatic function (antioxidant capacity, immune status, and glycolytic activity) in Tibetan lambs. Ninety two-month-old rams with an average weight of 15.37 ± 0.92 kg were randomly assigned to LP-L (dietary Lys/Met = 1:1), LP-M (dietary Lys/Met = 2:1) and LP-H (dietary Lys/Met = 3:1) treatments. The trial was conducted over 100 d, including 10 d of adaption to the diets. Hepatic phenotypes, antioxidant capacity, immune status, glycolytic activity and gene expression profiling was detected after the conclusion of the feeding trials. The results showed that the body weight was higher in the LP-L group when compared to those on the LP-M group (P < 0.05). In addition, the activities of the catalase (CAT) and glutathione peroxidase (GSH-Px) in the LP-L group were significantly increased compared with the LP-M group (P < 0.05), while the malondialdehyde (MDA) levels in LP-H group were significantly decreased (P < 0.05). Compared with LP-H group, both hepatic glycogen (P < 0.01) and lactate dehydrogenase (LDH) (P < 0.05) were significantly elevated in LP-L group. For the LP-L group, the hepatocytes were arranged radially with the central vein in the center, and hepatic plates exhibited tight arrangement. Transcriptome analysis identified 29, 179, and 129 differentially expressed genes (DEGs) between the LP-M vs. LP-L, LP-H vs. LP-M, and LP-H vs. LP-L groups, respectively (Q-values < 0.05 and |log2Fold Change| > 1). Gene Ontology (GO) and correlation analyses showed that in the LP-L group, core genes (C1QA and JUNB) enriched in oxidoreductase activity were positively correlated with antioxidant indicators, while the MYO9A core gene enriched in the immune response was positively associated with immune indicators, and core genes enriched in molecular function (PDK3 and PDP2) were positively correlated with glycolysis indicators. In summary, low-protein diet with a low Lys/Met ratio (1:1) could reduce the hepatic oxidative stress and improve the glycolytic activity by regulating the expression of related genes of Tibetan sheep.

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Endocrine-metabolic adaptations in Dorper ewes: comparison between single and twin pregnancies during gestation, parturition, and postpartum

Santarosa

Ferreira²,

Hooper

et al. 2022

Trop Anim Health Prod

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The effects of Zinc-Methionine on glucose metabolism and insulin resistance during late pregnancy in ewes

Cited by 5 publications

References 53 publications

Endocrine-metabolic Adaptations in Dorper Ewes: Comparison Between Single and Twin Pregnancies During Gestation, Delivery, and Postpartum

Endocrine-metabolic Adaptations in Dorper Ewes: Comparison Between Single and Twin Pregnancies During Gestation, Delivery, and Postpartum

Effect of supplementing lysins and methionine to low-protein diets on growth performance, hepatic antioxidant capacity, immune status, and glycolytic activity of tibetan sheep

Endocrine-metabolic adaptations in Dorper ewes: comparison between single and twin pregnancies during gestation, parturition, and postpartum

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