The effects of wild bitter gourd fruit extracts on ICAM-1 expression in pulmonary epithelial cells of C57BL/6J mice and microRNA-221/222 knockout mice: Involvement of the miR-221/-222/PI3K/AKT/NF-κB pathway

Sung, Hsin-Ching; Liu, Chen‐Wei; Hsiao, Chien‐Yu; Lin, Shu‐Rung; Yu, I-Shing; Lin, Shu‐Wha; Chiang, Ming‐Hsien; Liang, Cher‐Wei; Pu, Chi-Ming; Chen, Yu‐Chen; Lin, Ming‐Shyan

doi:10.1016/j.phymed.2018.03.023

Cited by 19 publications

(14 citation statements)

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“…D treatment reduces the morbidity and mortality of patients with chronic kidney failure and end-stage renal disease by reducing inflammatory mechanisms (Assimon et al 2012 ). Our previous studies and other reports demonstrated that the inflammatory cytokines TNF-α and IL-1β increased ICAM-1 expression and monocyte adhesion in human lung epithelial cells and lung tissues (Oh and Kwon 2009 ; Sung et al 2015 , 2018 ; Peng et al 2018 ). Furthermore, this study shows for the first time to show that Vit.…”

Section: Discussionmentioning

confidence: 74%

“…MAPK, PI3K/AKT and NF-κB pathways play vital roles in regulating the expression of pro-inflammatory cytokines, leading to the occurrence and development of lung inflammation (Lee and Yang 2013 ; Sung et al 2015 , 2018 ). In our study, as reported in previous studies, MAPK, AKT and NF-κB were strongly phosphorylated in A549 cells treated with TNF-α (Lee and Yang 2013 ; Oh and Kwon 2009 ).…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy

et al. 2021

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and mechanisms of action of vitamin D 3 (Vit. D) on the expression of intercellular adhesion molecule-1 (ICAM-1) in vitro and in vivo with or without tumor necrosis factor α (TNF-α) treatment. Pretreatment with Vit. D reduced the expression of ICAM-1 and leukocyte adhesion in TNF-α-treated A549 cells. TNF-α increased the accumulation of mitochondrial reactive oxygen species (mtROS), while Vit. D reduced this effect. Pretreatment with Vit. D attenuated TNF-α-induced mitochondrial fission, as shown Abstract Previous work has shown an association between vitamin D 3 deficiency and an increased risk for acquiring various inflammatory diseases. Vitamin D 3 can reduce morbidity and mortality in these patients via different mechanisms. Lung inflammation is an important event in the initiation and development of respiratory disorders. However, the anti-inflammatory effects of vitamin D 3 and the underlying mechanisms remained to be determined. The purpose of this study was to examine the effects

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy

et al. 2021

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“…Recently, it was reported that MC extracts reduced intercellular adhesion molecule-1 expression and upregulated mir-221/-222 in TNF-α treated lung tissues in mice, also decreasing PI3K/Akt/NF-κB/IκB. MC extracts were given before TNF-α, suggesting that bitter melon supplementation may be useful as a chemo-preventive agent in individuals at risk for inflammatory-related diseases (Sung et al, 2018). Therefore, MC exerts its anti-inflammatory effects by acting on several important signaling pathways involved in inflammation.…”

Section: Anti-inflammatory and Anti-oxidant Activity Of Momordica Chamentioning

confidence: 99%

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

2019

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Momordica charantia , commonly called bitter melon, is a plant belonging to Cucurbitaceae family known for centuries for its pharmacological activities, and nutritional properties. Due to the presence of many bioactive compounds, some of which possess potent biological actions, this plant is used in folk medicine all over the world for the treatment of different pathologies, mainly diabetes, but also cancer, and other inflammation-associated diseases. It is widely demonstrated that M. charantia extracts contribute in lowering glycaemia in patients affected by type 2 diabetes. However, the majority of existing studies on M. charantia bioactive compounds were performed only on cell lines and in animal models. Therefore, because the real impact of bitter melon on human health has not been thoroughly demonstrated, systematic clinical studies are needed to establish its efficacy and safety in patients. Besides, both in vitro and in vivo studies have demonstrated that bitter melon may also elicit toxic or adverse effects under different conditions. The aim of this review is to provide an overview of anti-inflammatory and anti-neoplastic properties of bitter melon, discussing its pharmacological activity as well as the potential adverse effects. Even if a lot of literature is available about bitter melon as antidiabetic drug, few papers discuss the anti-inflammatory and anti-cancer properties of this plant.

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“…MAP30 induces p300, a histone acetyltransferase, and promotes histone H3 acetylation in leukemia cells [18]. Bitter melon fruit extract shows anti-inflammatory effects in human lung epithelial cells by upregulating micro RNAs miR-221 and miR-222 [109]. This indicates that regulation in gene expression by bitter melon might be due to epigenetic modification activity; however, detailed studies are needed to elucidate these mechanisms.…”

Section: Epigenetic Modificationmentioning

confidence: 99%

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy

Sur

Ray

2020

Cancers

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Cancer is the second leading cause of death worldwide. Many dietary plant products show promising anticancer effects. Bitter melon or bitter gourd (Momordica charantia) is a nutrient-rich medicinal plant cultivated in tropical and subtropical regions of many countries. Traditionally, bitter melon is used as a folk medicine and contains many bioactive components including triterpenoids, triterpene glycoside, phenolic acids, flavonoids, lectins, sterols and proteins that show potential anticancer activity without significant side effects. The preventive and therapeutic effects of crude extract or isolated components are studied in cell line-based models and animal models of multiple types of cancer. In the present review, we summarize recent progress in testing the cancer preventive and therapeutic activity of bitter melon with a focus on underlying molecular mechanisms. The crude extract and its components prevent many types of cancers by enhancing reactive oxygen species generation; inhibiting cancer cell cycle, cell signaling, cancer stem cells, glucose and lipid metabolism, invasion, metastasis, hypoxia, and angiogenesis; inducing apoptosis and autophagy cell death, and enhancing the immune defense. Thus, bitter melon may serve as a promising cancer preventive and therapeutic agent.

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The effects of wild bitter gourd fruit extracts on ICAM-1 expression in pulmonary epithelial cells of C57BL/6J mice and microRNA-221/222 knockout mice: Involvement of the miR-221/-222/PI3K/AKT/NF-κB pathway

Cited by 19 publications

References 23 publications

Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy

Vitamin D3 decreases TNF-α-induced inflammation in lung epithelial cells through a reduction in mitochondrial fission and mitophagy

Momordica charantia, a Nutraceutical Approach for Inflammatory Related Diseases

Bitter Melon (Momordica Charantia), a Nutraceutical Approach for Cancer Prevention and Therapy

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