The effects of whole-body cryotherapy on oxidative stress in multiple sclerosis patients

Miller, Elżbieta; Mrowicka, Małgorzata; Malinowska, Katarzyna; Mrowicki, Jerzy; Saluk-Juszczak, Joanna; Kędziora, J

doi:10.1016/j.jtherbio.2010.08.006

Cited by 38 publications

(40 citation statements)

References 22 publications

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“…Hypoxia (decreased oxygen availability) is strictly connected with chronic inflammation, that is one of the main feature of neurodegeneration in MS [57]. Axonal loss is the main reason of disability progression in MS [59][60][61]. Patients with secondary progressive multiple sclerosis (SPMS) had lower activity of SOD [62,63].…”

Section: Multiple Sclerosismentioning

confidence: 99%

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Miller¹,

Morel²,

Saso³

et al. 2015

CTMC

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Neurodegeneration is the hallmark of many chronic progressive neurogical disorders characterized by specific clinical, morphological and biochemical features. Central nervous system is very sensitive to oxidative stress, which is considered as a key factor of neurodegenerative disorders. Therefore, many therapeutical strategies are focused on molecules with redox activity to re-establish the equilibrium between pro and antioxidants. Due to the fact that melatonin readily crosses the blood- brain-barrier, concomitant with its safety profile at the highest dosages makes this dietary supplement very useful in possible clinical application in neurodegeneration. Melatonin is currently marketed in several countries as a dietary supplement with no prescription. Clinical trials have shown different effectiveness of melatonin supplementation in several disorders, including neurodegenerative disorders. Melatonin has unique biochemical properties such as scavenging of hydroxyl, carbonate, alkoxyl, peroxyl and aryl cation radicals and stimulation of activities main antioxidative enzymes (glutathione peroxidase, superoxide dismutase etc.). Moreover, it can suppress nitric oxide synthase. The present paper highlighted the potential clinical role of melatonin in main neurodegenerative diseases including Alzheimer disease, Parkinson disease, amylotrophic lateral sclerosis and multiple sclerosis. Moreover, in this review the main molecular aspects of melatonin in brain cell protection and survival mechanisms were discussed. Therefore, melatonin is regarded as a potential therapeutical agent in clinical application in neurodegenerative disorders, but this findings needs to be confirmed by the larger, more well-designed clinical trials.

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Section: Multiple Sclerosismentioning

confidence: 99%

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Miller¹,

Morel²,

Saso³

et al. 2015

CTMC

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“…Recently, we have shown a significant and positive impact of a series of 10 sessions of WBC in MS patients with neurological deficits (muscle strength increase, decreased spasticity, disability reduction, and a higher level of antioxidative status) . However, the impact of WBC on functional status (physical and psychological aspects) and quality of life in MS patients with fatigue syndrome is unknown .…”

Section: Introductionmentioning

confidence: 99%

Whole-body cryostimulation (cryotherapy) provides benefits for fatigue and functional status in multiple sclerosis patients. A case-control study

et al. 2016

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“…The cardiovascular changes have a stimulating effect, and therefore, the cryotherapy is used to combat pain, as anti-inflammation therapy, and also for relaxation and improving neurological, as well as psychological conditions [4][5][6]. Although, the range of indications treated by the whole body cryotherapy is quite wide, the optimal treatment conditions are still not established.…”

Section: Introductionmentioning

confidence: 99%

“…Frequently, the 3-min exposure in -110°C is recommended [7][8][9][10][11][12]; however, the treatment in -175°C is used, as well [13,14]. The applications of other temperatures are also reported, e.g., -100, -120, and -130°C [2,4,6]. Exposure times also vary from 1 [15] to 3 min [8,16,17].…”

Section: Introductionmentioning

confidence: 99%

Application of thermovision for estimation of the optimal and safe parameters of the whole body cryotherapy

Dębiec-Bąk

Skrzek

Podbielska

2012

J Therm Anal Calorim

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Exposure to the extreme low temperatures, ranging between -60 and -140°C, has many beneficial effects on the human body what is exploited for example in sport medicine, for treatment of locomotory system diseases or even some psychiatric disorders. To insure the safe treatment in a cryochamber, careful planning of the procedure and proper qualification of patients, is required. Cardiovascular system, especially skin vasculature plays the major role of the body response to the extreme cold. The changes in skin blood flow are reflected in changes of the temperature distribution. Therefore, the thermal imaging, which allows to analyze the temperature distribution on the human body, may be successfully exploited to examine the influence of extremely low temperatures on the skin vascular system. The aim of this work was to examine the temperature, blood pressure, and heart rate changes after the whole body cryotherapy in healthy subjects to determine the safety conditions of the treatment. 480 healthy students of the Wrocław University School of Physical Education were divided into two groups (each 240 persons). All subjects were exposed for 1-3 min to the extremely low temperatures: -60, -100, -120, and -140°C. In one group, the thermograms were recorded before and 5 and 30 min after the cryotherapy by means of ThermoVision A20 M thermal camera. In the other one, heart rate and blood pressure were measured before and 5 min after the cryotherapy. It was demonstrated that 3-min exposure in the cryochamber and the temperature -120°C are the optimal and safe cryotherapy parameters.

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The effects of whole-body cryotherapy on oxidative stress in multiple sclerosis patients

Cited by 38 publications

References 22 publications

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Melatonin Redox Activity. Its Potential Clinical Applications in Neurodegenerative Disorders

Whole-body cryostimulation (cryotherapy) provides benefits for fatigue and functional status in multiple sclerosis patients. A case-control study

Application of thermovision for estimation of the optimal and safe parameters of the whole body cryotherapy

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