Objective: To assess the effect of graduated compression stockings (GCS) on lower leg volume and leg complaints in runners during and after exercise.Design: Cross-sectional study. Setting: Radboud University Nijmegen Medical Centre and an outdoor running track in Nijmegen, The Netherlands.Patients or Other Participants: Thirteen Dutch trained recreational runners.Intervention(s): Participants used a GCS on 1 leg during running.Main Outcome Measures: (1) Lower leg volume of both legs was measured at baseline, directly after running, and at 5 minutes and 30 minutes after running using a validated perometer. (2) Leg complaints were reported on questionnaires at set intervals.Results: (1) In both experiments, the legs with GCS showed a reduction in mean (6 SEM) leg volume directly after running, as compared with the leg without GCS: À14.1 6 7.6 mL (P ¼ .04) for the 10-km running track and À53.5 6 17.8 mL (P ¼ .03) for the maximum exercise test. This effect was not observed at 5 and 30 minutes after running. (2) No differences in leg complaints were reported in either experiment.Conclusions: The GCS prevented an increase in leg volume just after the running exercise. However, this result was not accompanied by a reduction in subjective questionnaire-reported leg complaints. The practical consequences of the present findings need further study.Key Words: lower leg, leg volume, venous hemodynamics G raduated compression stockings (GCS) are gaining popularity among athletes in various sports disciplines, such as running. In athletes, increased arterial inflow in the legs may impair venous outflow, which may result in complaints of venous insufficiency. Furthermore, the feet of runners absorb 1.5 to 3 times body weight at every step.1 This may result in injuries such as cramps and medial tibial stress syndrome, impeding optimal muscle functioning during the next exercise.Studies have demonstrated beneficial effects of GCS on venous hemodynamics. The GCS support and stimulate the calf muscle pump, increasing venous return and reducing leg edema. 2,3 Recently, the use of GCS has become a growing trend among athletes, with the aim of improving venous return by applying graduated compression around the calves. This may increase end-diastolic volume, with an improvement of the cardiac output as a result, allowing athletes to perform at the same intensity with less cardiac stress or to increase their exercise intensity and performance. 4 Furthermore, GCS may reduce muscular vibrations triggered by the contact of the feet with the ground, thereby reducing lateral movements of the gastrocnemius muscle, resulting in less traction on the Achilles tendon and less muscular damage. 4,5 Few authors have investigated the effect of GCS on performance and recovery after exercise among various sports disciplines. These show conflicting results. [4][5][6][7][8][9][10][11][12][13][14] Three recent studies demonstrated the effect of wearing GCS during running in trained male runners. [4][5][6] In 2 of these studies, 4,5 the effect of wearing...