The Effects of Volatile Anesthetics on Lung Ischemia-Reperfusion Injury: Basic to Clinical Studies

Oshima, Yoshiaki; Otsuki, Akihiro; Endo, Ryo; Nakasone, Masato; Harada, Tomonari; Takahashi, Shunsaku; Inagaki, Yoshimi

doi:10.1016/j.jss.2020.11.042

Cited by 11 publications

(7 citation statements)

References 136 publications

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“…Sevoflurane is a volatile anesthetic that is frequently used in the clinic due to its advantages, such as having a low blood-gas partition coefficient, providing sufficient depth of anesthesia in a short time, short awakening time, less airway irritation, and being able to be used in inhalation anesthesia. 35 The protective effects of sevoflurane at different pathways in IRI have been demonstrated in various studies.…”

Section: Discussionmentioning

confidence: 99%

Effects of sevoflurane and fullerenol C60 on lower limb ischemia–reperfusion injury in streptozocin-induced diabetic mice

Polat,

Şengel,

Küçük

et al. 2024

Science Progress

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Background: Ischemia–reperfusion injury (IRI) poses a significant challenge for physicians, necessitating the management of cell damage and the preservation of organ functions. Various surgical procedures, such as vascular surgery on extremities, temporary cross-clamping of the abdominal aorta in aortic surgery, and the use of a tourniquet in extremity surgeries, may induce lower limb IRI. The susceptibility to IRI is heightened in individuals with diabetes. This study aimed to investigate the effects of fullerenol C60 and sevoflurane on mouse muscle tissue in a lower limb IRI model and to assess their potential in preventing complications arising from ischemia–reperfusion in mice with streptozocin-induced diabetes. Methods: A total of 36 adult Swiss albino mice were randomly divided into six groups, each consisting of six mice: control group (group C), diabetes group (group D), diabetes–ischemia/reperfusion group (group DIR), diabetes–ischemia/reperfusion–fullerenol C60 group (group DIR-FC60), diabetes–ischemia/reperfusion–sevoflurane group (group DIR-S), and diabetes–ischemia/reperfusion–sevoflurane–fullerenol C60 group (DIR-S-FC60). Streptozocin (55 mg/kg) was intraperitoneally administered to induce diabetes in the relevant groups, with mice displaying blood glucose levels of 250 mg/dL or higher at 72 h were considered diabetic. After 4 weeks, all groups underwent laparotomy under anesthesia. In DIR-FC60 and DIR-S-FC60 groups, fullerenol C60 (100 mg/kg) was intraperitoneally administrated 30 min before the ischemia period. Sevoflurane, delivered in 100% oxygen at a rate of 2.3% and 4 L/min, was administered during the ischemia period in DIR-S and DIR-S-FC60 groups. In the IR groups, a microvascular clamp was placed on the infrarenal abdominal aorta for 120 min during the ischemia period, followed by the removal of the clamp and a 120-min reperfusion period. At the end of the reperfusion, gastrocnemius muscle tissues were removed for histopathological and biochemical parameter examinations. Results: Histopathological examination revealed a significant reduction in the disorganization and degeneration of muscle cells in the DIR-S-FC60 group compared to the DIR group (p = 0.041). Inflammatory cell infiltration was notably lower in the DIR-S, DIR-FC60, and DIR-S-FC60 groups than in the DIR group (p = 0.031, p = 0.011, and p = 0.013, respectively). The total damage scores in the DIR-FC60 and DIR-S-FC60 groups were significantly lower than in the DIR group (p = 0.018 and p = 0.008, respectively). Furthermore, the levels of malondialdehyde (MDA) in the DIR-S, DIR-FC60, and DIR-S-FC60 groups were significantly lower than in the DIR group (p < 0.001, p < 0.001, and p < 0.001, respectively). Catalase (CAT) enzyme activity in the DIR-S, DIR-FC60, and DIR-S-FC60 groups was higher than in the DIR group (p = 0.001, p = 0.014, and p < 0.001, respectively). Superoxide dismutase (SOD) enzyme activity in the DIR-FC60 and DIR-S-FC60 groups was also higher than in the DIR group (p < 0.001 and p = 0.001, respectively). Conclusion: Our findings indicate that administering fullerenol C60 30 min prior to ischemia in diabetic mice, in combination with sevoflurane, led to a reduction in oxidative stress and the correction of IR-related damage in muscle tissue histopathology. We believe that the administration of fullerenol C60 before IR, coupled with sevoflurane administration during IR, exerts a protective effect in mice.

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Section: Discussionmentioning

confidence: 99%

Effects of sevoflurane and fullerenol C60 on lower limb ischemia–reperfusion injury in streptozocin-induced diabetic mice

Polat,

Şengel,

Küçük

et al. 2024

Science Progress

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“…Moreover, longer isoflurane-maintained anesthesia induced more alveolar macrophage aggregation, but less phagocytic activity (Kotani et al 1998). Long term exposure to isoflurane is also related to airway inflammation (Oshima et al;Odeh et al 2022. IL-8 is one of the key chemokines involved in the migration of epithelial granulocytes, which promote pulmonary inflammation and asthma (Cromwell et al 1992).…”

Section: Discussionmentioning

confidence: 99%

Physiological and Pathological Evaluation of Mechanically Ventilated Anesthetized Pigs

2023

Int J Vet Sci

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Prolonged assisted ventilation during anesthesia and critical care is associated with increased morbidity and mortality in both humans and animals. However, no study of mechanically ventilated patients has examined the mortality-related physiology and pathology. Our study investigated physiological, hematological and pathological changes in pigs that died during anesthesia. Six pigs were placed under ventilation-assisted anesthesia for up to 48h. The heart rate (HR), respiratory rate (RR), mean arterial blood (MAP), end-tidal carbon dioxide (ETCO2), and oxygen saturation (SpO2) were monitored every 15min until the pigs dies. Blood glucose, serum lactate, pH, and serum bicarbonate (HCO3-) were measured every 12h until death. Tissues were harvested from lung, liver, heart, and kidney of pigs immediately after death during anesthesia. All pigs died during anesthesia. Times of death varied. One pig died at approximately 18h (Group I), two pigs at 24h (Group II), one pig at 36h (Group III), and two pigs at 48h (Group IV). Decreased MAP was reported in all groups throughout anesthesia. Each group showed different changes before death; Group I and III showed decreased blood glucose (45mg/dL) and (17mg/dL), respectively; Group III showed elevated serum lactate (9.76 mmol/l) and reduced pH (7.13) that suggested metabolic acidosis; Group IV showed increased ETCO2 (64.35±5.79 mmHg). Pigs that survived longer showed a higher level of cellular injury to the liver and respiratory system. Blood glucose, MAP, and ETCO2 should be carefully monitored during anesthesia for better patient outcomes and reduced mortality.

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“…A potential role of the anaesthetic regimen on the rate of postoperative pulmonary complications (PPCs) in cardiac surgery has been suggested [ 2 ]. Proposed mechanisms for VA lung protection include anti-inflammatory, antioxidant, and anti-apoptotic effects on endothelial cells, immunocompetent cells, and epithelial cells by inhibiting nuclear factor kappa B (NF-kB), mitogen-activated protein kinase (MAPK), and protein kinase C (PKC) signalling, as well as by inhibiting overexpression of inducible nitric oxide synthase (iNOS) and maintaining expression of endothelial nitric oxide synthase (eNOS) [ 99 ]. These lung protective effects of VA might be triggered by the small amounts of ROS induced by VA. VA also exert a lung protective effect on the glycocalyx present on the surface of pulmonary endothelium and on the tight junctions between alveolar epithelial and endothelial cells [ 99 ].…”

Section: Clinical Translation Of Anaesthetic Cardioprotectionmentioning

confidence: 99%

Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery—A Narrative Review

Ştefan

Predoi

Goicea

et al. 2022

JCM

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Recent research has contested the previously accepted paradigm that volatile anaesthetics improve outcomes in cardiac surgery patients when compared to intravenous anaesthesia. In this review we summarise the mechanisms of myocardial ischaemia/reperfusion injury and cardioprotection in cardiac surgery. In addition, we make a comprehensive analysis of evidence comparing outcomes in patients undergoing cardiac surgery under volatile or intravenous anaesthesia, in terms of mortality and morbidity (cardiac, neurological, renal, pulmonary).

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The Effects of Volatile Anesthetics on Lung Ischemia-Reperfusion Injury: Basic to Clinical Studies

Cited by 11 publications

References 136 publications

Effects of sevoflurane and fullerenol C60 on lower limb ischemia–reperfusion injury in streptozocin-induced diabetic mice

Effects of sevoflurane and fullerenol C60 on lower limb ischemia–reperfusion injury in streptozocin-induced diabetic mice

Physiological and Pathological Evaluation of Mechanically Ventilated Anesthetized Pigs

Volatile Anaesthesia versus Total Intravenous Anaesthesia for Cardiac Surgery—A Narrative Review

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