The Effects of Vitamin D Supplementation on Anthropometric and Biochemical Indices in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Rezaei, Shahla; Tabrizi, Reza; Nowrouzi-Sohrabi, Peyman; Jalali, Mohammad; Shabani-Borujeni, Mojtaba; Modaresi, Shayan; Doaei, Saeid

doi:10.3389/fphar.2021.732496

Cited by 20 publications

(18 citation statements)

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“…The duration of vitamin D supplementation ranged from 8 to 43 weeks. The location of the studies were as follows: four in China ( 20 , 24 – 26 ), two in Iran ( 18 , 27 ), two in United States ( 28 , 29 ), one each in Philippines ( 30 ), Bahrain ( 17 ), India ( 19 ), Australia ( 31 ), United Kingdom ( 32 ), and Brazil ( 33 ). Table 1 describes the quality of randomized controlled trials that were included in the included meta-analyses.…”

Section: Resultsmentioning

confidence: 99%

“…The results of the meta-analysis are also contradictory in this regard. While some meta-analysis studies show a positive effect of the vitamin D supplement on weight loss and waist circumference ( 17 , 18 ), some have reported ineffectiveness of the supplementation on anthropometric indices ( 19 , 20 ). Therefore, we conducted present umbrella meta-analysis to clarify the effect of vitamin D supplementation on anthropometric indices in different health conditions.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

et al. 2022

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Despite the growing evidence from meta-analyses on vitamin D’s anti-obesity properties, their results are controversial. The current umbrella review was performed to assess the available evidence and provide a conclusive explanation in this regard. The international databases PubMed, Scopus, Embase, Web of Science and Google Scholar were systematically searched till March, 2022. A random-effects model was used to run the meta-analysis. All meta-analyses that examined the effect of vitamin D supplementation on BW, BMI, WC, and fat mass were included. Findings of 14 meta-analyses revealed that vitamin D supplementation reduced body mass index (BMI) (ES: −0.11 kg/m2; 95% CI: −0.18, −0.05, p?0.001; I2 = 61.0%, p < 0.001), and waist circumference (WC) (ES = −0.79 cm; 95% CI: −1.20, −0.37; p < 0.001; I2 = 46.5%, p = 0.096) in comparison to control group. However, the effects of vitamin D on body weight (ES = −0.16 kg, 95% CI: −0.36, 0.04; p = 0.125; I2 = 57.0%, p = 0.017), and fat mass (ES: 0.02, 95% CI: −0.20, 0.24, p = 0.868; I2 = 0.0%, p = 0.531) were not considerable. Vitamin D supplementation significantly improved levels of obesity indices such as BMI, and WC.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

et al. 2022

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“…The evaluation of the efficacy of 6 months of intramuscular vitamin D supplementation in improving liver-related parameters in NAFLD patients found that a single monthly intramuscular dose of cholecalciferol was effective in improving laboratory and fibroscan markers in NAFLD patients [ 128 ]. The effect of vitamin D supplementation on anthropometric and biochemical variables in NAFLD patients was investigated in a recent meta-analysis; the results showed that vitamin D significantly improved indices such as high-density lipoprotein-cholesterol, body weight, body mass index, waist circumference, serum alanine transaminase, serum fasting blood glucose, homeostatic model assessment for insulin resistance (HOMA-IR), and calcium markers, suggesting its use as an alternative treatment strategy for NAFLD patients [ 129 ].…”

Section: Possible Mechanisms Of the Association Between Vitamin D–vdr...mentioning

confidence: 99%

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Αγγελετοπούλου

Thomopoulos

Mouzaki

et al. 2022

IJMS

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There is consistent evidence that vitamin D deficiency is strongly associated with liver dysfunction, disease severity, and poor prognosis in patients with liver disease. Vitamin D and its receptor (VDR) contribute to the regulation of innate and adaptive immune responses. The presence of genetic variants of vitamin D- and VDR-associated genes has been associated with liver disease progression. In our recent work, we summarized the progress in understanding the molecular mechanisms involved in vitamin D–VDR signaling and discussed the functional significance of VDR signaling in specific cell populations in liver disease. The current review focuses on the complex interaction between immune and liver cells in the maintenance of liver homeostasis and the development of liver injury, the interplay of vitamin D and VDR in the development and outcome of liver disease, the role of vitamin D- and VDR-associated genetic variants in modulating the occurrence and severity of liver disease, and the therapeutic value of vitamin D supplementation in various liver diseases. The association of the vitamin D–VDR complex with liver dysfunction shows great potential for clinical application and supports its use as a prognostic index and diagnostic tool.

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“…Recently, extra-hepatic health benefits were reported following vitamin D supplementation in NAFD [improvements in HDL-cholesterol, body weight, BMI, ALT, insulin resistance and fasting glycaemia], the authors suggesting that vitamin D supplementation should be included in the management of patients with NAFDL. [51]. Covid-19 illness.…”

Section: Than Any Others Remains Unacceptable Since Deficiency Increa...mentioning

confidence: 99%

Vitamin D deficiency in British South Asians, a persistent but avoidable problem associated with many health risks (including rickets, T2DM, CVD, COVID-19 and pregnancy complications): the case for correcting this deficiency

Boucher

2022

Endocrine Connections

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High vitamin D deficiency rates, with rickets and osteomalacia, have been common in south Asians (SAs) arriving in Britain since the 1950s with preventable infant deaths from hypocalcaemic status-epilepticus and cardiomyopathy. Vitamin D deficiency increases common SA disorders (type 2 diabetes and cardiovascular disease), recent trials and non-linear Mendelian randomisation studies having shown deficiency to be causal for both disorders. Ethnic minority, obesity, diabetes and social deprivation are recognised COVID-19 risk factors but vitamin D deficiency isn’t, despite convincing mechanistic evidence of it. Adjusting analyses for obesity/ethnicity abolishes vitamin D deficiency in COVID-19 risk prediction but both factors lower serum 25(OH)D specifically. Social deprivation inadequately explains increased ethnic-minority COVID-19 risks. SA vitamin D deficiency remains uncorrected after 70 years, official bodies using ‘education’, ‘assimilation’ and ‘diet’ as ‘proxies’ for ethnic differences and increasing pressures to assimilate. Meanwhile, English rickets was abolished from ~1940 by free ‘welfare foods’ (meat, milk, eggs, cod-liver-oil), for all pregnant/nursing mothers and young children (<5 years old). Cod-liver-oil was withdrawn from antenatal clinics from 1994 (for excessive vitamin A teratogenicity), without alternative provision. The take-up of 2006 ‘Healthy-Start’ scheme food-vouchers for low-income families with young children (<3 years old) has been poor, being inaccessible and poorly publicized. COVID-19 pandemic advice for UK adults in ‘lockdown’ was ‘400 IU vitamin D/day’, inadequate for correcting the deficiency seen winter/summer at 17.5%/5.9% in White, 38.5%/30% in Black and 57.2%/50.8% in SA people in representative UK Biobank subjects when recruited ~14 years ago and remaining similar in 2018. Vitamin D inadequacy worsens many non-skeletal health risks. Not providing vitamin D for preventing SA rickets and osteomalacia continues to be unacceptable, as deficiency-related health risks increase ethnic health disparities, while abolishing vitamin D deficiency would be easier and more cost-effective than correcting any other factor worsening ethnic minority health in Britain

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The Effects of Vitamin D Supplementation on Anthropometric and Biochemical Indices in Patients With Non-alcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis

Cited by 20 publications

References 63 publications

Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

Vitamin D supplementation positively affects anthropometric indices: Evidence obtained from an umbrella meta-analysis

Vitamin D–VDR Novel Anti-Inflammatory Molecules—New Insights into Their Effects on Liver Diseases

Vitamin D deficiency in British South Asians, a persistent but avoidable problem associated with many health risks (including rickets, T2DM, CVD, COVID-19 and pregnancy complications): the case for correcting this deficiency

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