The effects of vitamin D<sub>3</sub> during pregnancy and lactation on offspring physiology and behavior in Sprague–Dawley rats

Pan, Pauline; Jin, Daniel H.S.; Chatterjee-Chakraborty, Munmun; Halievski, Katherine; Lawson, Daeria O.; Remedios, David; Smetka, Cassandra; Pinto, Vânia Lopes; Parra, Esteban J.; Fleming, Alison S.

doi:10.1002/dev.21086

Cited by 28 publications

(11 citation statements)

References 43 publications

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“…Although sunlight-induced vitamin D is not an important source of vitamin D for lower animals, it has been shown that prenatal dietary vitamin D in Sprague-Dawley rats has significant effects on postnatal anxiety and social behaviors (Pan et al, 2013). …”

Section: Discussionmentioning

confidence: 99%

Evidence for phenotypic plasticity in response to photic cues and the connection with genes of risk in schizophrenia

Miller¹

2013

Front. Behav. Neurosci.

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Numerous environmental factors have been identified as influential in the development of schizophrenia. Some are byproducts of modern life, yet others were present in our evolutionary past and persist to a lesser degree in the current era. The present study brings together published epidemiological data for schizophrenia and data on variables related to photic input for places of residence across geographical regions, using rainfall as an inverse, proxy measure for light levels. Data were gathered from the literature for two countries, the former Yugoslavia and Ireland, during a time in the early 20th century when mobility was relatively limited. The data for Yugoslavia showed a strong correlation between hospital census rates for schizophrenia (by place of birth) and annual rain (r = 0.96, p = 0.008). In Ireland, the hospital census rates and first admissions for schizophrenia (by place of permanent residence) showed a trend for correlation with annual rain, reaching significance for 1st admissions when the rainfall data was weighted by the underlying population distribution (r = 0.71, p = 0.047). In addition, across the years 1921–1945, birth-year variations in a spring quarter season-of-birth effect for schizophrenia in Ireland showed a trend for correlation with January-March rainfall (r = 0.80, p ≤ 0.10). The data are discussed in terms of the effect of photoperiod on the gestation and behavior of offspring in animals, and the premise is put forth that vestigial phenotypic plasticity for such photic cues still exists in humans. Moreover, genetic polymorphisms of risk identified for psychotic disorders include genes modulated by photoperiod and sunlight intensity. Such a relationship between phenotypic plasticity in response to a particular environmental regime and subsequent natural selection for fixed changes in the environmentally responsive genes, has been well studied in animals and should not be discounted when considering human disease.

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Section: Discussionmentioning

confidence: 99%

Evidence for phenotypic plasticity in response to photic cues and the connection with genes of risk in schizophrenia

Miller¹

2013

Front. Behav. Neurosci.

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“…Juvenile progeny of VDD Sprague-Dawley rat dams treated from mating until weaning showed heightened anxiety-like behaviors, as measured by significantly increased grooming frequency compared to other groups when tested in the elevated plus maze (EPM, measures anxiety-like and exploratory behaviors) (Pan et al 2014). Interestingly, juvenile offspring of dams provided an excessive vitamin D diet (10.0 IU/g) also showed significantly increased grooming frequency during social behavior and learning tests (Pan et al 2014). Effects of maternal VDD on anxiety-related behavior appear to be independent of the hypothalamic-pituitary-axis (HPA) with one study showing normal function in rats born to VDD dams (Eyles et al 2006).…”

Section: Neuro-affective Disordersmentioning

confidence: 99%

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Ideraabdullah

Belenchia

Rosenfeld

et al. 2019

Journal of Endocrinology

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Vitamin D is an essential nutrient that is metabolized in the body to generate an active metabolite (1,25(OH)2D) with hormone-like activity and highly diverse roles in cellular function. Vitamin D deficiency (VDD) is a prevalent but easily preventable nutritional disturbance. Emerging evidence demonstrates the importance of sufficient vitamin D concentrations during fetal life with deficiencies leading to long-term effects into adulthood. Here, we provide a detailed review and perspective of evidence for the role of maternal VDD in offspring long-term health, particularly as it relates to developmental origins of health and disease (DOHaD). We focus on the roles in neurobehavioral and cardiometabolic disorders in humans and highlight recent findings from zebrafish and rodent models that probe potential mechanisms linking early life VDD to later life health outcomes. Moreover, we explore evidence implicating epigenetic mechanisms as a mediator of this link. Gaps in our current understanding of how maternal VDD might result in deleterious offspring outcomes later in life are also addressed.

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“…For instance, U- and J-shaped associations between 25(OH)D concentration and disease outcomes have been previously reported [ 27 , 28 , 29 ] and could also exist in relation to neurodevelopment and maternal vitamin D status. Adverse effects of elevated 25(OH)D concentration on both offspring behavior and physiology have been observed in animal models [ 30 ] but it is unknown on how translatable this is to humans.…”

Section: Introductionmentioning

confidence: 99%

Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

et al. 2017

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Vitamin D has an important role in early life; however, the optimal vitamin D status during pregnancy is currently unclear. There have been recent calls for pregnant women to maintain circulating 25-hydroxyvitamin D (25(OH)D) concentrations >100 nmol/L for health, yet little is known about the long-term potential benefits or safety of achieving such high maternal 25(OH)D concentrations for infant or child health outcomes. We examined maternal vitamin D status and its associations with infant anthropometric and later childhood neurocognitive outcomes in a mother-child cohort in a sun-rich country near the equator (4.6° S). This study was conducted in pregnant mothers originally recruited to the Seychelles Child Development Nutrition Study. Blood samples (n = 202) taken at delivery were analysed for serum 25-hydroxyvitamin D (25(OH)D) concentrations. Multiple linear regression models assessed associations between maternal 25(OH)D and birth weight, infant head circumference, and neurocognitive outcomes in the children at age 5 years. Mothers were, on average, 27 years of age, and the children’s average gestational age was 39 weeks. None of the women reported any intake of vitamin D supplements. Maternal 25(OH)D concentrations had a mean of 101 (range 34–218 nmol/L) and none were deficient (<30 nmol/L). Maternal 25(OH)D concentrations were not associated with child anthropometric or neurodevelopmental outcomes. These findings appear to indicate that a higher vitamin D status is not a limiting factor for neonatal growth or neurocognitive development in the first 5 years of life. Larger studies with greater variability in vitamin D status are needed to further explore optimal cut-offs or non-linear associations (including for maternal health) that might exist among populations with sub-optimal exposure.

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The effects of vitamin D₃ during pregnancy and lactation on offspring physiology and behavior in Sprague–Dawley rats

Cited by 28 publications

References 43 publications

Evidence for phenotypic plasticity in response to photic cues and the connection with genes of risk in schizophrenia

Evidence for phenotypic plasticity in response to photic cues and the connection with genes of risk in schizophrenia

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

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The effects of vitamin D3 during pregnancy and lactation on offspring physiology and behavior in Sprague–Dawley rats

Cited by 28 publications

References 43 publications

Evidence for phenotypic plasticity in response to photic cues and the connection with genes of risk in schizophrenia

Evidence for phenotypic plasticity in response to photic cues and the connection with genes of risk in schizophrenia

Maternal vitamin D deficiency and developmental origins of health and disease (DOHaD)

Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

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The effects of vitamin D₃ during pregnancy and lactation on offspring physiology and behavior in Sprague–Dawley rats