The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials

Dashti, Fatemeh; Mousavi, Seyed Mohammad; Larijani, Bagher; Esmaillzadeh, Ahmad

doi:10.1016/j.phrs.2021.105727

Cited by 7 publications

(5 citation statements)

References 70 publications

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“…A meta-analysis of 24 RCTs did not find such an association [74]. However, if meta-analyses of RCTs are restricted to populations with specific diseases, such as diabetes, abnormal glucose homeostasis, and psychiatric disorders, statistically significant inverse associations between vitamin D supplementation and CRP were observed [75][76][77].…”

Section: Vitamin D Status and Crp-based Biomarkers Of Sirmentioning

confidence: 95%

About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants

et al. 2023

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It is unknown whether the well-known association between vitamin D deficiency and mortality could be explained by the immune system modulating effects of vitamin D, which may protect from a systemic inflammatory response (SIR) to adverse health conditions. This study aims to investigate the interrelationships of vitamin D deficiency, biomarkers of SIR, and mortality. We used multivariate logistic regression with adjustment for 51 covariates to assess the associations of vitamin D deficiency with disadvantageous levels of nine biomarkers of SIR in the UK Biobank cohort. Furthermore, we tested with Cox regression and mediation analysis whether biomarkers of SIR and vitamin D deficiency were independently associated with mortality. We included 397,737 participants aged 37–73 years. Vitamin D deficiency was associated with disadvantageous levels of all blood cell count-based biomarkers, but not with C-reactive protein (CRP)-based biomarkers after adjustment for body weight. Vitamin D deficiency and all biomarkers of SIR were significantly associated with all-cause mortality and mortality from cancer, cardiovascular and respiratory disease. The strength of these associations was unaltered if vitamin D deficiency and biomarkers of SIR were put in the same model. This finding was further supported by the mediation analyses. This study showed that vitamin D deficiency is associated with disadvantageous levels of blood cell count-based but not CRP-based biomarkers of SIR. Vitamin D deficiency and systemic inflammation were independently and strongly associated with mortality. The potential of clinical interventions against both vitamin D deficiency and underlying causes of systemic inflammation should be explored.

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Section: Vitamin D Status and Crp-based Biomarkers Of Sirmentioning

confidence: 95%

About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants

et al. 2023

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“…Indeed, VitD deficiency is related to endothelial dysfunction, partially because of the downregulation of the VitD Receptor (VDR) [ 18 ]. Consistently, VitD supplementation in VitD-deficient diabetic patients improved endothelial function [ 19 ], and a recent systematic review and metanalysis of randomized clinical trials demonstrated that VitD supplementation decreases circulating inflammatory cytokines in patients with altered glucose tolerance [ 20 ]. However, another study reported no significant effects of VitD supplementation on endothelial dysfunction [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein

et al. 2021

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Vitamin D (VitD) exerts protective effects on the endothelium, which is fundamental for vascular integrity, partly by inhibiting free radical formation. We found that VitD prevents high glucose-induced Thioredoxin Interacting Protein (TXNIP) upregulation. Increased amounts of TXNIP are responsible for the accumulation of reactive oxygen species and, as a consequence, of lipid droplets. This is associated with increased amounts of triglycerides as the result of increased lipogenesis and reduced fatty acid oxidation. Remarkably, VitD rebalances the redox equilibrium, restores normal lipid content, and prevents the accumulation of lipid droplets. Our results highlight TXNIP as one of the targets of VitD in high glucose-cultured endothelial cells and shed some light on the protective effect of VitD on the endothelium.

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“…270 Supplementation of vitamin D in patients with abnormal glucose homeostasis could reduce the expression of related inflammatory cytokines, such as CRP, TNF-α, and IL-6. 271 A healthy diet could improve inflammation in overweight or obese people and reduce risk of developing DM. 272 As compared with traditional low-fat diet, traditional low-carbohydrate diet could regulate blood glucose and downregulate inflammatory cytokines, suggesting low-carbohydrate diet could improve the subclinical inflammatory state of T2DM patients.…”

Section: Healthy Diet and Exercisementioning

confidence: 99%

“…In a short‐term study, vitamin C was found to improve blood glucose control and blood pressure in patients with T2DM 270 . Supplementation of vitamin D in patients with abnormal glucose homeostasis could reduce the expression of related inflammatory cytokines, such as CRP, TNF‐α, and IL‐6 271 . A healthy diet could improve inflammation in overweight or obese people and reduce risk of developing DM 272 .…”

Section: Therapeutic Interventions Targeting Inflammation In Diabetesmentioning

confidence: 99%

Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions

Zhao,

Hu,

Zhang

et al. 2024

MedComm

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At present, diabetes mellitus (DM) has been one of the most endangering healthy diseases. Current therapies contain controlling high blood sugar, reducing risk factors like obesity, hypertension, and so on; however, DM patients inevitably and eventually progress into different types of diabetes complications, resulting in poor quality of life. Unfortunately, the clear etiology and pathogenesis of diabetes complications have not been elucidated owing to intricate whole‐body systems. The immune system was responsible to regulate homeostasis by triggering or resolving inflammatory response, indicating it may be necessary to diabetes complications. In fact, previous studies have been shown inflammation plays multifunctional roles in the pathogenesis of diabetes complications and is attracting attention to be the meaningful therapeutic strategy. To this end, this review systematically concluded the current studies over the relationships of susceptible diabetes complications (e.g., diabetic cardiomyopathy, diabetic retinopathy, diabetic peripheral neuropathy, and diabetic nephropathy) and inflammation, ranging from immune cell response, cytokines interaction to pathomechanism of organ injury. Besides, we also summarized various therapeutic strategies to improve diabetes complications by target inflammation from special remedies to conventional lifestyle changes. This review will offer a panoramic insight into the mechanisms of diabetes complications from an inflammatory perspective and also discuss contemporary clinical interventions.

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The effects of vitamin D supplementation on inflammatory biomarkers in patients with abnormal glucose homeostasis: A systematic review and meta-analysis of randomized controlled trials

Cited by 7 publications

References 70 publications

About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants

About the associations of vitamin D deficiency and biomarkers of systemic inflammatory response with all-cause and cause-specific mortality in a general population sample of almost 400,000 UK Biobank participants

Vitamin D Prevents High Glucose-Induced Lipid Droplets Accumulation in Cultured Endothelial Cells: The Role of Thioredoxin Interacting Protein

Inflammation in diabetes complications: molecular mechanisms and therapeutic interventions

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