The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma

Arshi, Saba; Fallahpour, Morteza; Nabavi, Mohammad; Bemanian, Mohammad Hasan; Javad-Mousavi, Seyed Ali; Nojomi, Marzieh; Esmaeilzadeh, Hossein; Molatefi, Rasol; Rekabi, Mahsa; Jalali, Farhad; Akbarpour, Nadieh

doi:10.1016/j.anai.2014.07.005

Cited by 62 publications

(58 citation statements)

References 39 publications

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“…Arshi et al conducted an RCT enrolling 130 patients with moderate persistent asthma and found vitamin D supplementation to be associated with asthma controllers that could significantly improve FEV1 in mild to moderate persistent asthma after 24 weeks [34]. In addition, Yadav and Mittal reported monthly doses of 60,000 IU vitamin D3 significantly reduced the number of exacerbations as compared with placebo and PEFR significantly increased in the treatment group [35].…”

Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Levels and Vitamin D Supplement in Adult Patients with Asthma Exacerbation

et al. 2016

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Introduction. Vitamin D deficiency has been linked to an increased risk of asthma exacerbations. Objective. This study aimed to compare vitamin D status during the period of severe asthma exacerbations and investigate if vitamin D supplementation improves asthma control. Methods. A total of 47 asthmatic patients and 40 healthy subjects participated in this study. Serum 25-hydroxyvitamin D (25(OH)D), asthma control test (ACT) score, and % predicted peak expiratory flow rate were evaluated in the period with and without severe asthma exacerbations. After that, we provided vitamin D2 supplements to the patients with low vitamin D levels for 3 months. Results. At the period of asthma exacerbation, the prevalence of vitamin D deficiency and insufficiency was 38.29% and 34.04%. There was no significant difference in the levels of serum 25(OH)D with and without asthma exacerbations but the levels were significantly higher in the healthy group. Serum 25(OH)D levels significantly correlated with ACT score. Moreover, vitamin D2 supplementation improved asthma control in uncontrolled asthma group. Conclusions. Hypovitaminosis D was common in asthmatic patients but was not the leading cause of asthma exacerbations. Serum 25(OH)D levels correlated with the ability to control asthma. Improving vitamin D status might be a benefit in uncontrolled asthmatic patients.

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Section: Discussionmentioning

confidence: 99%

Serum Vitamin D Levels and Vitamin D Supplement in Adult Patients with Asthma Exacerbation

et al. 2016

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“…Monthly doses of vitamin D, 60,000 IU per month for six months, significantly reduced the number of asthma exacerbations, requirement for steroids and emergency room visits in asthmatic patients [30]. Vitamin D supplementation was also found to significantly improve FEV 1 in patients with mild to moderate persistent asthma after 24 weeks [31]. …”

Section: Vitamin D and Asthmamentioning

confidence: 99%

The impact of vitamin D on asthmatic human airway smooth muscle

Hall

Fischer

Agrawal

2015

Expert Review of Respiratory Medicine

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Asthma is a chronic heterogeneous disorder, which involves airway inflammation, airway hyperresponsiveness (AHR) and airway remodeling. The airway smooth muscle (ASM) bundle regulates the broncho-motor tone and plays a critical role in AHR as well as orchestrating inflammation. Vitamin D deficiency has been linked to increased severity and exacerbations of symptoms in asthmatic patients. It has been shown to modulate both immune and structural cells, including ASM cells, in inflammatory diseases. Given that current asthma therapies have not been successful in reversing airway remodeling, vitamin D supplementation as a potential therapeutic option has gained a great deal of attention. Here, we highlight the potential immunomodulatory properties of vitamin D in regulating ASM function and airway inflammation in bronchial asthma.

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“…Recent studies introduced a genetic factor, vitamin D receptor gene polymorphisms, that is responsible for vitamin D deficiency in children. In this regard, the predictive role of some polymorphisms such as FokI, ApaI, and TaqI has been suggested, but not completely understood [2]. Also, in a developing long time series transcriptome data (DLCGS) in order to infer the role of in utero changes of vitamin D responsive genes in both the developing lung and asthma, some evidences have been obtained the set of vitamin D related genes to be associated with lung development [3], but these gene associations have not been clearly determined in other population-based studies.…”

Section: Introductionmentioning

confidence: 99%

Vitamin D deficiency and its impact on asthma severity in asthmatic children

et al. 2016

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BackgroundDespite obtaining evidences on association between vitamin D and development of lung in fetus, little is known about vitamin D level and its impact on severity of asthma in children. The present study aimed to assess the relationship between the asthma severity and vitamin D deficiency in asthmatic children.MethodsThis case-control study was conducted on 106 individuals including asthmatic (n = 53) and healthy children (n = 53) who referred to Mofid hospital in Tehran in 2013. The level of serum vitamin D in both groups was measured by radioimmunoassay method at the reference lab and was categorized as sufficient (> 30 ng/ml), insufficient (20 to 30 ng/ml), or deficient (< 20 ng/ml). The control status of asthma in patients group was classified as controlled, partially controlled, and uncontrolled.ResultsIn the groups with and without asthma, the prevalence of vitamin D deficiency was 73.6 and 49.1%, and the prevalence of vitamin D insufficiency was 18.9 and 18.9%, while normal vitamin D level was revealed in 7.5 and 32.1%, respectively with a significant difference (p = 0.005). Using the multivariate logistic regression analysis, the presence of asthma was associated with reduced level of vitamin D (OR = 1.068, 95% CI: 1.027–1.110, P = 0.001). In this context, the risk for asthma in the children with vitamin D deficiency was 6.3 times of those with normal vitamin D level. Although the presence of asthma was strongly associated with reduced level of vitamin D in serum, neither severity of asthma nor control status of asthma were associated with vitamin D deficiency.ConclusionThe presence of vitamin D deficiency effectively predict increased risk for childhood asthma; however the severity or control status of this event may not be predicted by confirming vitamin D deficiency.

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The effects of vitamin D supplementation on airway functions in mild to moderate persistent asthma

Cited by 62 publications

References 39 publications

Serum Vitamin D Levels and Vitamin D Supplement in Adult Patients with Asthma Exacerbation

Serum Vitamin D Levels and Vitamin D Supplement in Adult Patients with Asthma Exacerbation

The impact of vitamin D on asthmatic human airway smooth muscle

Vitamin D deficiency and its impact on asthma severity in asthmatic children

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