The effects of vitamin D supplementation on lipid profiles and oxidative indices among diabetic nephropathy patients with marginal vitamin D status

Barzegari, Maliheh; Sarbakhsh, Parvin; Mobasseri, Majid; Noshad, Hamid; Esfandiari, Asra; Khodadadi, Behnam; Gargari, Bahram Pourghassem

doi:10.1016/j.dsx.2018.11.008

Cited by 37 publications

(46 citation statements)

References 25 publications

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“…In the RCT of Barzegari et al [79] DN patients with marginal serum vitamin D have been treated with 1.25-dihydroxycholecalciferol (50,000 IU/week) for 8 weeks. Vitamin D supplementation significantly increased vitamin D levels in the intervention group; a significant reduction in the serum levels of triglycerides, low density lipoproteins and total cholesterol ( p = 0.04, p = 0.006 and p = 0.02, respectively) has also been reported in treated patients.…”

Section: Vitamin D and Diabetes In Kidney Diseasesmentioning

confidence: 99%

Role of Vitamin D Status in Diabetic Patients with Renal Disease

et al. 2019

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Diabetes mellitus (DM) poses a major public health problem worldwide, with ever-increasing incidence and prevalence in recent years. The Institute for Alternative Futures (IAF) expects that the total number of people with type 1 and type 2 DM in the United States will increase by 54%, from 19,629,000 to 54,913,000 people, between 2015 and 2030. Diabetic Nephropathy (DN) affects about one-third of patients with DM and currently ranks as the first cause of end-stage kidney disease in the Western world. The complexity of interactions of Vitamin D is directly related with progressive long-term changes implicated in the worsening of renal function. These changes result in a dysregulation of the vitamin D-dependent pathways. Various studies demonstrated a pivotal role of Vitamin D supplementation in regression of albuminuria and glomerulosclerosis, contrasting the increase of glomerular basement membrane thickening and podocyte effacement, with better renal and cardiovascular outcomes. The homeostasis and regulation of the nephron’s function are absolutely dependent from the cross-talk between endothelium and podocytes. Even if growing evidence proves that vitamin D may have antiproteinuric, anti-inflammatory and renoprotective effects in patients with DN, it is still worth investigating these aspects with both more in vitro studies and randomized controlled trials in larger patient series and with adequate follow-up to confirm the effects of long-term vitamin D analogue supplementation in DN and to evaluate the effectiveness of this therapy and the appropriate dosage.

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Section: Vitamin D and Diabetes In Kidney Diseasesmentioning

confidence: 99%

Role of Vitamin D Status in Diabetic Patients with Renal Disease

et al. 2019

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“…The association between vitamin D deficiency and insulin resistance has been also proposed [2]. Numerous clinical studies showed that vitamin D supplementation reduces the level of metabolic parameters such as total cholesterol (TC), low-density lipoprotein (LDL), triglyceride (TG), glycated hemoglobin (HbA1c), as well as decreases insulin resistance indicator—HOMA-IR—in T2DM patients [3,4,5,6,7]. However, it is not fully recognized how vitamin D may reduce the risk of metabolic disorders development.…”

Section: Introductionmentioning

confidence: 99%

Analysis of Association between Vitamin D Deficiency and Insulin Resistance

2019

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Recent evidence revealed extra skeleton activity of vitamin D, including prevention from cardiometabolic diseases and cancer development as well as anti-inflammatory properties. It is worth noting that vitamin D deficiency is very common and may be associated with the pathogenesis of insulin-resistance-related diseases, including obesity and diabetes. This review aims to provide molecular mechanisms showing how vitamin D deficiency may be involved in the insulin resistance formation. The PUBMED database and published reference lists were searched to find studies published between 1980 and 2019. It was identified that molecular action of vitamin D is involved in maintaining the normal resting levels of ROS and Ca2+, not only in pancreatic β-cells, but also in insulin responsive tissues. Both genomic and non-genomic action of vitamin D is directed towards insulin signaling. Thereby, vitamin D reduces the extent of pathologies associated with insulin resistance such as oxidative stress and inflammation. More recently, it was also shown that vitamin D prevents epigenetic alterations associated with insulin resistance and diabetes. In conclusion, vitamin D deficiency is one of the factors accelerating insulin resistance formation. The results of basic and clinical research support beneficial action of vitamin D in the reduction of insulin resistance and related pathologies.

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“…El Hajj et al have found that vitamin D triggers to significantly diminish of HOMA-IR, FPG, TC, and LDL, but without any significant changes in HbA1c [ 9 ]. The results of studies conducted by Barzegardi et al have presented pronounced decrease in serum levels of TG, LDL, and TC in diabetic nephropathy patients after supplementation with vitamin D [ 10 ]. Taken together, these observations support that vitamin D improves metabolic control of diabetes.…”

Section: Introductionmentioning

confidence: 99%

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

Szymczak-Pajor

Drzewoski

Śliwińska

2020

IJMS

105

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Numerous studies have shown that vitamin D deficiency is very common in modern societies and is perceived as an important risk factor in the development of insulin resistance and related diseases such as obesity and type 2 diabetes (T2DM). While it is generally accepted that vitamin D is a regulator of bone homeostasis, its ability to counteract insulin resistance is subject to debate. The goal of this communication is to review the molecular mechanism by which vitamin D reduces insulin resistance and related complications. The university library, PUBMED, and Google Scholar were searched to find relevant studies to be summarized in this review article. Insulin resistance is accompanied by chronic hyperglycaemia and inflammation. Recent studies have shown that vitamin D exhibits indirect antioxidative properties and participates in the maintenance of normal resting ROS level. Appealingly, vitamin D reduces inflammation and regulates Ca2+ level in many cell types. Therefore, the beneficial actions of vitamin D include diminished insulin resistance which is observed as an improvement of glucose and lipid metabolism in insulin-sensitive tissues.

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The effects of vitamin D supplementation on lipid profiles and oxidative indices among diabetic nephropathy patients with marginal vitamin D status

Cited by 37 publications

References 25 publications

Role of Vitamin D Status in Diabetic Patients with Renal Disease

Role of Vitamin D Status in Diabetic Patients with Renal Disease

Analysis of Association between Vitamin D Deficiency and Insulin Resistance

The Molecular Mechanisms by Which Vitamin D Prevents Insulin Resistance and Associated Disorders

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