The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial

Raygan, Fariba; Ostadmohammadi, Vahidreza; Bahmani, Fereshteh; Asemi, Zatollah

doi:10.1016/j.pnpbp.2018.02.007

Cited by 77 publications

(102 citation statements)

References 44 publications

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“…Two of the studies included in the qualitative review were excluded from quantitative analysis because they did not report sufficient data and the corresponding authors could not be contacted. The 25 trials included in the meta‐analysis were conducted in Australia (4 trials: Dean et al, 2011; Lansdowne & Provost, 1998; Mousa, Naderpoor, de Courten, & de Courten, 2018; Sanders et al, 2011), Iran (8 trials: Alavi et al, 2018; Ghaderi et al, 2017; Jamilian et al, 2018; Khoraminya et al, 2013; Mozaffari‐Khosravi, Nabizade, Yassini‐Ardakani, Hadinedoushan, & Barzegar, 2013; Raygan, Ostadmohammadi, Bahmani, & Asemi, 2018; Sepehrmanesh et al, 2016; Vaziri et al, 2016), Norway (4 trials: Grung et al, 2017; Jorde & Kubiak, 2018; Jorde et al, 2008; Kjaergaard et al, 2012), United States (4 trials: Arvold et al, 2009; Bertone‐Johnson et al, 2012; Mason et al, 2016; Yalamanchili & Gallagher, 2012), Denmark (1 trial: Frandsen, Pareek, Hansen, & Nielsen, 2014), China (1 trial: Wang et al, 2016), Netherlands (1 trial: Rolf et al, 2017), Sweden (1 trial: von Berens et al, 2018), and New Zealand (1 trial: Choukri, Conner, Haszard, Harper, & Houghton, 2018). Sample size ranged from 34 to 726.…”

Section: Resultsmentioning

confidence: 99%

“…We consider that the effects of vitamin D on depression and anxiety are capable of explanation by a common mechanism. However, there have been fewer studies of anxiety and a greater diversity of tools have been used to measure anxiety (Choukri et al, 2018; Dean et al, 2011; Ghaderi et al, 2017; Jamilian et al, 2018; Kjaergaard et al, 2012; Raygan et al, 2018; Tartagni et al, 2016), so the finding that vitamin D supplementation reduces anxiety should be viewed conservatively.…”

Section: Discussionmentioning

confidence: 99%

“…As for the limited response in elderly people it is difficult to offer an explanation due to the presence of confounding factors. For example, 3 of the 5 studies of elderly people included subjects without clinically meaningful depression (Alavi et al, 2018; Raygan et al, 2018; Sanders et al, 2011; von Berens et al, 2018; Yalamanchili & Gallagher, 2012) and baseline vitamin D levels and dosage were variable (Alavi et al, 2018; Raygan et al, 2018; Sanders et al, 2011; von Berens et al, 2018; Yalamanchili & Gallagher, 2012). The recommended dose for vitamin D supplementation is higher for elderly people than other age groups (Bacon, Gamble, Horne, Scott, & Reid, 2009; Hanley et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

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The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Cheng

Huang

2020

Depress Anxiety

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Background The several meta‐analyses of the effect of vitamin D on depression have produced inconsistent results and studies dealing with anxiety were not incorporated. There has been no comprehensive analysis of how results are affected by the nature of the sample or the dosage and duration of supplementation. The study is aimed to investigate whether vitamin D supplementation reduces negative emotions and to analyze the possible influence of sample and regimen. Method We conducted a systematic review and meta‐analysis of randomized controlled trials comparing the effect of vitamin D and placebo on negative emotion. Databases were searched for relevant articles published before February 2019. Results The analysis covered 25 trials with a total of 7,534 participants and revealed an effect of vitamin D on negative emotion (Hedges' g = −0.4990, 95% CI [−0.8453, −0.1528], p = .0047, I2 = 97.7%). Subgroup analysis showed that vitamin D had an effect on patients with major depressive disorder and on subjects with serum 25(OH)D levels ≤50 nmol/L. The pooled data from trials of vitamin D supplementation lasting ≥8 weeks and dosage ≤4,000 IU/day indicated that vitamin D had an effect. Conclusions Our results support the hypothesis that vitamin D supplementation can reduce negative emotions. Patients with major depressive disorder and individuals with vitamin D deficiency are most likely to benefit from supplementation. But to interpret the results with high heterogeneity should still be cautious.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Cheng

Huang

2020

Depress Anxiety

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“…In a small study by Arnson et al [85], five days of cholecalciferol treatment attenuated some inflammatory and endothelial markers (CRP, VCAM-1 and IL-6). Likewise, Raygan et al found reduced vascular inflammation (hsCRP) and metabolic improvements in diabetic patients supplemented with 12 weeks of vitamin D [88,89]. Low calcium intake and low vitamin D status have been associated with obesity and diabetes mellitus [92,93].…”

Section: Discussionmentioning

confidence: 99%

Potential Beneficial Effects of Vitamin D in Coronary Artery Disease

et al. 2019

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Vitamin D plays a pivotal role in bone homeostasis and calcium metabolism. However, recent research has indicated additional beneficial effects of vitamin D on the cardiovascular system. This review aims to elucidate if vitamin D can be used as an add-on treatment in coronary artery disease (CAD). Large-scale epidemiological studies have found a significant inverse association between serum 25(OH)-vitamin D levels and the prevalence of essential hypertension. Likewise, epidemiological data have suggested plasma levels of vitamin D to be inversely correlated to cardiac injury after acute myocardial infarction (MI). Remarkably, in vitro trials have showed that vitamin D can actively suppress the intracellular NF-κB pathway to decrease CAD progression. This is suggested as a mechanistic link to explain how vitamin D may decrease vascular inflammation and atherosclerosis. A review of randomized controlled trials with vitamin D supplementation showed ambiguous results. This may partly be explained by heterogeneous study groups. It is suggested that subgroups of diabetic patients may benefit more from vitamin D supplementation. Moreover, some studies have indicated that calcitriol rather than cholecalciferol exerts more potent beneficial effects on atherosclerosis and CAD. Therefore, further studies are required to clarify these assumptions.

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“…et al, 2016;Dhaliwal et al, 2018;Lew et al, 2018), B. longum (Bercik et al, 2010(Bercik et al, , 2011Savignac et al, 2014;Allen et al, 2016) and B. breve (Savignac et al, 2014;Okubo et al, 2019;Tian et al, 2019). Moreover, MSPs intake often decreased depression and anxiety simultaneously in randomized controlled trials (Mohammadi et al, 2016;Kouchaki et al, 2017;Jamilian et al, 2018;Raygan et al, 2018;Ostadmohammadi et al, 2019;Salami et al, 2019).…”

Section: Heterogeneity Of Depressionmentioning

confidence: 98%

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

et al. 2020

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The accumulating knowledge of the host-microbiota interplay gives rise to the microbiota-gut-brain (MGB) axis. The MGB axis depicts the interkingdom communication between the gut microbiota and the brain. This communication process involves the endocrine, immune and neurotransmitters systems. Dysfunction of these systems, along with the presence of gut dysbiosis, have been detected among clinically depressed patients. This implicates the involvement of a maladaptive MGB axis in the pathophysiology of depression. Depression refers to symptoms that characterize major depressive disorder (MDD), a mood disorder with a disease burden that rivals that of heart diseases. The use of probiotics to treat depression has gained attention in recent years, as evidenced by increasing numbers of animal and human studies that have supported the antidepressive efficacy of probiotics. Physiological changes observed in these studies allow for the elucidation of probiotics antidepressive mechanisms, which ultimately aim to restore proper functioning of the MGB axis. However, the understanding of mechanisms does not yet complete the endeavor in applying probiotics to treat MDD. Other challenges remain which include the heterogeneous nature of both the gut microbiota composition and depressive symptoms in the clinical setting. Nevertheless, probiotics offer some advantages over standard pharmaceutical antidepressants, in terms of residual symptoms, side effects and stigma involved. This review outlines antidepressive mechanisms of probiotics based on the currently available literature and discusses therapeutic potentials of probiotics for depression.

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The effects of vitamin D and probiotic co-supplementation on mental health parameters and metabolic status in type 2 diabetic patients with coronary heart disease: A randomized, double-blind, placebo-controlled trial

Cited by 77 publications

References 44 publications

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

The effect of vitamin D supplement on negative emotions: A systematic review and meta‐analysis

Potential Beneficial Effects of Vitamin D in Coronary Artery Disease

Antidepressive Mechanisms of Probiotics and Their Therapeutic Potential

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