The Effects of Vitamin D Fortified Products on Bone Bi-omarkers: A Systematic Review and Meta-Analysis

Emadzadeh, Maryam; Mehdizadeh, Atieh; Sharifan, Payam; Khoshakhlagh, Mahdieh; Sahebi, Reza; Sadeghi, Ramin; Ferns, Gordon A.; Ghayour‐Mobarhan, Majid

doi:10.18502/ijph.v51i2.8681

Cited by 4 publications

(17 citation statements)

References 62 publications

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“…The systematic reviews included 2 to 40 vitamin D fortification trials. Of the 27 systematic reviews, 5 included children only [44,[56][57][58]60], and 7 included exclusively adults [36,42,43,[46][47][48]59], while in 15 reviews all age groups were included [35,[37][38][39][40][41]45,[49][50][51][52][53][54][55]61]. Most of the systematic reviews included studies of both sexes, with the exception of two studies including only women [48,53].…”

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

“…While most of the studies did not apply restrictions based on the geographic location of the study [35][36][37][38][39][40][41][42][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61], one systematic review included only RCTs from Iran [43]. Only eight systematic reviews reported data on other forms of vitamin D intake, e.g., from sun exposure or dietary vitamin D intake from other foods or supplements [35,36,38,40,41,52,58,59].…”

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

“…The types of vehicles included in the systematic reviews are shown in Table S3, Supplementary File S3. The dose of fortification varied between 60-5000 IU/day in most systematic reviews, with the exception of two studies that used 28,000 IU/day of vitamin D for fortification [49,51]. The intervention duration ranged from three weeks to 30 months in the studies included.…”

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

“…Among the 27 included systematic reviews, 22 reported the effect of vitamin D fortification on serum 25(OH)D concentrations [35][36][37][38][40][41][42][43][44][45][46][47][48][51][52][53][55][56][57][58][59][60], 9 reviews reported serum parathormone (PTH) levels [37,38,40,41,[46][47][48]51,53], 3 reported serum calcium (Ca) [38,40,53] and 4 systematic reviews reported adverse effects [35,41,55,58]. Five systematic reviews examined the effect of vitamin D-fortified foods on bone markers e.g., osteocalcin (OC), alkaline phosphatase (ALP), total procollagen type 1 N-terminal propeptide (P1NP), serum telopeptides of type-1 collagen (CTX) and bone mineral density (BMD) [37,38,48,51,53]. Regarding anthropometric parameters, two reviews described the effect of food fortification with vitamin D [47,50].…”

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

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Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews

Nyakundi,

Némethné Kontár,

Kovács

et al. 2023

Nutrients

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Vitamin D deficiency is a global public health concern with significant implications for bone health and chronic disease prevention. Our aim was to summarize the evidence from Cochrane and other systematic reviews evaluating the benefits or harms of vitamin D fortification of staple foods for household use. In April 2023, we systematically searched Ovid MEDLINE, Embase, Epistemonikos and the Cochrane Database of Systematic Reviews for systematic reviews investigating the effects of vitamin D fortification of food in general populations of any age. We used Cochrane methodology and assessed the methodological quality of included studies using AMSTAR (A MeaSurement Tool to Assess Systematic Reviews). We assessed the degree of overlap among reviews. All outcomes included in systematic reviews were assessed. The protocol is registered in PROSPERO (registration number: CRD42023420991). We included 27 systematic reviews out of 5028 records for analysis. Overall, 11 out of 12 systematic reviews calculating pooled estimates reported a significant increase in serum 25(OH)D concentrations. The mean change in serum 25(OH)D concentrations per additional 100 units of vitamin D ranged from 0.7 to 10.8 nmol/L. Fortification of food with vitamin D showed a reduction in the prevalence of vitamin D deficiency based on high-certainty evidence. Parathormone (PTH) levels were described to decrease, bone mineral density to increase, while the effects on other bone turnover markers were inconsistent. Fortification did not significantly impact most anthropometric parameters, but it seemed to positively influence lipid profiles. In summary, fortification of food with vitamin D results in a reduction of vitamin D deficiency and might increase serum 25(OH)D concentrations, to varying extents depending on the fortified vehicle and population characteristics. Additionally, fortification may have a positive impact on bone turnover and lipid metabolism but may only have a limited effect on anthropometric parameters.

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Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

Section: Description Of Included Systematic Reviewsmentioning

confidence: 99%

See 2 more Smart Citations

Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews

Nyakundi,

Némethné Kontár,

Kovács

et al. 2023

Nutrients

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“…A meta-analysis conducted in 2017 on twenty randomised clinical trials (RCT) showed that consumption of vitamin-fortified foods can significantly increase serum 25(OH)D and bone mineral density levels and decrease PTH concentrations, without having a beneficial effect on bone turnover markers (12) . In another meta-analysis of forty RCT in 2020, vitamin D fortification resulted in significant reductions in serum levels of PTH and C-terminal telopeptide of type-I collagen (CTX), with no impact on bone mineral density (13) . These two meta-analyses evaluated the effect of vitamin D fortification on bone markers regardless of biological differences in the two sexes.…”

mentioning

confidence: 99%

Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis

Nasimi,

Jamshidi,

Askari

et al. 2024

Br J Nutr

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Vitamin D is a vital indicator of musculoskeletal health, as it plays an important role through the regulation of bone and mineral metabolism. This meta-analysis was performed to investigate the effects of vitamin D supplementation/fortification on bone turnover markers in women. All human randomized clinical trials (RCTs) reported changes in bone resorption markers (serum C-terminal Telopeptide of type-I collagen (sCTX) and urinary type I collagen cross-linked N-telopeptide (uNTX)) or bone formation factors (osteocalcin (OC), bone alkaline phosphatase (BALP), and Procollagen type-1 intact N-terminal Propeptide (P1NP)) following vitamin D administration in women (aged ≥18 years old) were considered. Mean differences (MDs) and their respective 95% confidence intervals (CIs) were calculated based on fixed or random effects models according to the heterogeneity status. Subgroup analyses, meta-regression models, sensitivity analysis, risk of bias, publication bias, and the quality of the included studies were also evaluated. We found that vitamin D supplementation had considerable effect on sCTX (MD: -0.038, n= 22) and OC (MD: -0.610, n=24) with high heterogeneity and uNTX (MD: -8.188, n= 6) without heterogeneity. Our results showed that age, sample size, dose, duration, baseline vitamin D level, study region, and quality of studies might be sources of heterogeneity in this meta-analysis. Subgroup analysis also revealed significant reductions in P1NP level in dose less than 600IU/day and larger study sample size (>100 participants). Moreover, no significant change was found in BALP level. Vitamin D supplementation/fortification significantly reduced bone resorption markers in women. However, results were inconsistent for bone formation markers.

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Effect of Education on Knowledge and Attitude Level Related to Vitamin D in Pharmacy Students

Lorensia,

Mahmudah,

Naim

et al. 2023

J. Trop. Pharm. Chem.

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Indonesia is a country located in the tropics with sun exposure throughout the season. Sun exposure is the best source of vitamin D and there have been no cases of vitamin D intoxication due to excessive sun exposure. Pharmacy students tend to lack knowledge of vitamin D. Changes in lifestyle and modernization lead to high use of sunscreens which can lead to a decrease in the synthesis of vitamin D in the skin. This research was conducted to determine the differences in knowledge and attitudes towards sun exposure using cross sectional method on 100 first semester pharmacy students and 100 final semester students. Test differences in aspects of knowledge and attitudes using odds ratios. The results of the knowledge aspect odds ratio test are 1,000 and the attitude aspect odds ratio test results were 0.583 so that it can be concluded that both knowledge and attitudes towards sun exposure have the same risk tendency for first semester and final semester pharmacy students.

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The Effects of Vitamin D Fortified Products on Bone Bi-omarkers: A Systematic Review and Meta-Analysis

Cited by 4 publications

References 62 publications

Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews

Fortification of Staple Foods for Household Use with Vitamin D: An Overview of Systematic Reviews

Effect of vitamin D supplementation or fortification on bone turnover markers in women: a systematic review and meta-analysis

Effect of Education on Knowledge and Attitude Level Related to Vitamin D in Pharmacy Students

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