The effects of vitamin D supplemantation on prognosis in patients with mild  obstructive sleep apnea syndrome

Ayyıldız, Feride; Yıldıran, Hilal; Afandiyeva, Nigar; Gülbahar, Özlem; Köktürk, Oğuz

doi:10.3906/sag-2101-83

Cited by 7 publications

(5 citation statements)

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“…Collectively, our findings and those of previous epidemiological studies raise the possibility that reduced bioavailability and activity of 25(OH)D in OSA may facilitate the emergence and progression of the pathophysiology of the MetS. Moreover, in light of interventional data indicating that vitamin D supplementation may have beneficial effects on individual cardiometabolic risk factors (e.g., glucose metabolism, lipidemic profile, and inflammation) both in the general population [ 50 ] and in patients with OSA [ 51 – 53 ], vitamin D supplementation may prove beneficial for the management of both the respiratory and the cardiometabolic manifestations of OSA in vitamin D deficient subjects. Nevertheless, whether such an approach would lead to a meaningful reduction in cardiovascular risk in OSA remains unknown.…”

Section: Discussionsupporting

confidence: 66%

Associations between serum vitamin D status and the cardiometabolic profile of patients with obstructive sleep apnea

et al. 2023

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Purpose Obstructive sleep apnea (OSA) and the metabolic syndrome (MetS) frequently coexist. Low serum vitamin D has been positively associated with OSA presence and severity; however, data on its link to cardiometabolic features in patients with OSA remain scarce. We aimed to assess serum 25-hydroxyvitamin D [25(OH)D] and explore its association with cardiometabolic parameters in OSA. Methods This was a cross-sectional study among 262 patients (49 ± 9 years old, 73% men) with polysomnography-diagnosed OSA. Participants were evaluated in terms of anthropometric indices, lifestyle habits, blood pressure, biochemical, plasma inflammatory and urinary oxidative stress markers, and the presence of MetS. Serum 25(OH)D was assessed by chemiluminescence, and vitamin D deficiency (VDD) was defined as 25(OH)D < 20 ng/mL. Results Median (1st, 3rd quartile) serum 25(OH)D levels were 17.7 (13.4, 22.9) ng/mL and 63% of participants had VDD. Serum 25(OH)D correlated negatively with body mass index (BMI), homeostasis model of assessment of insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein (hsCRP), and urinary oxidized guanine species (oxG), and positively with high-density lipoprotein cholesterol (all P < 0.050). In logistic regression analysis, serum 25(OH)D was associated with lower odds of MetS [odds ratio (95% confidence interval): 0.94 (0.90–0.98)], after adjustment for age, sex, season of blood sampling, Mediterranean diet score, physical activity, smoking, apnea–hypopnea index, HOMA-IR, hsCRP, and oxG. In the same multivariate model, VDD was associated with ~ twofold greater odds of MetS [2.39 (1.15, 4.97)]. Conclusion VDD is highly prevalent and is associated with a detrimental cardiometabolic profile among patients with OSA.

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Section: Discussionsupporting

confidence: 66%

Associations between serum vitamin D status and the cardiometabolic profile of patients with obstructive sleep apnea

et al. 2023

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“…Insulin resistance caused by obesity as well as low levels of vitamin D (Vit D) presented in obesity are also a risk factor of OSAS ( 13 , 24 , 25 ). Based on the association between levels of Vit D and OSAS, there was a study that investigated whether Vit D supplementation can improve the prognosis of mild OSAS and found that Vit D supplementation had a positive effect which could significantly decrease the AHI value of the patients ( 26 ).…”

Section: Discussionmentioning

confidence: 99%

Association Between Abdominal Adipose Tissue Distribution and Obstructive Sleep Apnea in Chinese Obese Patients

Wang

et al. 2022

Front. Endocrinol.

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PurposeFactors related to the occurrence of obstructive sleep apnea syndrome (OSAS) in obesity have not been fully clarified. The aim of this study was to identify the association between OSAS and abdominal fat distribution in a cohort of Chinese obese patients.MethodsThis cross-sectional study collected demographic data of 122 obese patients who were admitted into the in-patient unit of the Department of Endocrinology, Shanghai Tenth People’s Hospital from July 2018 to January 2021. OSAS was diagnosed based on the results of overnight polysomnography, and the abdominal fat distribution was measured by bioelectrical impedance analysis (BIA). Univariate and multivariate logistic regression analyses were used to investigate the association between OSAS and the distribution of abdominal fat.Results(1) The mean age (SD) of the obese patients included was 32.44 (11.81) years old, and the overall incidence rate of OSAS was 51.06%. Twenty-four (25.53%) patients had mild OSAS, 10 (10.64%) had moderate OSAS, and 14 (14.89%) had severe OSAS. The apnea hypopnea index (AHI) of men was significantly higher than that of women (5.50, interquartile range (IQR) 3.80–30.6 vs. 4.2, IQR 1.4–12 events/h, p = 0.014). Meanwhile, men had a significantly higher visceral fat area when compared with women (180.29 ± 51.64 vs. 143.88 ± 53.42 cm2, p = 0.002). (2) Patients with OSAS had a significantly higher waist circumference, fasting plasma glucose, 2 h postprandial plasma glucose, glycated hemoglobin, and visceral fat area than patients without OSAS (all p < 0.05). (3) AHI was significantly positively associated with BMI, neck circumference, waist circumference, and visceral fat area (r = 0.306, p = 0.003; r = 0.380, p < 0.001; r = 0.328, p = 0.002; r = 0.420, p < 0.001) but not with subcutaneous fat area (p = 0.094). Multivariate analysis demonstrated that abdominal fat area and fasting plasma glucose were independent risk factors for OSAS (odds ratio, 1.016; 95% confidence interval, 1.005–1,026, p = 0.005; odds ratio, 1.618; 95% confidence interval, 1.149–2.278, p = 0.006).ConclusionsIn obese patients, the abdominal visceral adipose deposit but not the subcutaneous fat area was associated with OSAS and was an independent risk factor for OSAS. Therefore, improving the distribution of abdominal fat may contribute to alleviating the severity of OSAS in obesity.

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“…On the other hand, with increasing OSA severity serum 25(OH)D levels further decreased, this suggests that serum 25(OH)D might be a risk factor for OSA [ 10 ]. Finally, markers of inflammation and HOMA-IR were significantly decreased after Vit D supplementation in a small group of patients with mild OSA [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?

Archontogeorgis

Voulgaris

Nena

et al. 2022

JPM

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Background: The coexistence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) has been defined as overlap syndrome (OVS). Recently, a link between OSA, COPD and Vitamin D (Vit D) serum concentration was reported, however, evidence regarding Vit D status in patients with OVS is scarce. The aim of the present study was to evaluate Vit D serum levels and to explore the association of those levels with anthropometric, pulmonary function and sleep parameters in patients with OVS. Methods: Vit D serum levels were measured in patients diagnosed with OVS, as confirmed by overnight polysomnography and pulmonary function testing. Results: A total of 90 patients (79 males and 11 females) were included in the analysis. The patients were divided into three groups matched for age, gender, and BMI: the control group that included 30 patients (27 males and 3 females), the OSA group that included 30 patients (26 males and 4 females), and the OVS group that included 30 patients (26 males and 4 females). Patients with OVS exhibited decreased serum 25(OH)D levels compared with OSA patients and controls (14.5 vs. 18.6 vs. 21.6 ng/mL, p < 0.001). In the OVS group, multiple linear regression analysis identified AHI and FEV1, as predictors of serum 25(OH)D levels (p = 0.041 and p = 0.038, respectively). Conclusions: Lower Vit D levels have been observed in patients with OVS compared with OSA patients and non-apneic controls, indicating an increased risk of hypovitaminosis D in this population which might be associated with disease severity.

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The effects of vitamin D supplemantation on prognosis in patients with mild obstructive sleep apnea syndrome

Cited by 7 publications

References 0 publications

Associations between serum vitamin D status and the cardiometabolic profile of patients with obstructive sleep apnea

Associations between serum vitamin D status and the cardiometabolic profile of patients with obstructive sleep apnea

Association Between Abdominal Adipose Tissue Distribution and Obstructive Sleep Apnea in Chinese Obese Patients

Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?

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