The effects of vitamin C supplementation on biomarkers of oxygen radical generated damage in human volunteers with “low” or “high” cholesterol levels

Protective Effects of Vitamin C, Alone or in Combination with Vitamin A, on Endotoxin-Induced Oxidative Renal Tissue Damage in Rats

“…Most rodents are able to produce Vit C (ascorbic acid), unlike humans and primates (Challem and Taylor 1998). Many health benefits have been attributed to ascorbic acid such as antioxidant, anti-atherogenic, anti-carcinogenic, immunomodulator and prevents cold (Steinbrecher et al 1990;Anderson et al 1997;Campbell et al 1999;Douglas et al 2000). Vit C is an important dietary antioxidant, it significantly decreases the adverse effect of reactive species such as reactive oxygen and nitrogen species that can cause oxidative damage to macromolecules such as lipids, DNA and proteins, which are implicated in chronic diseases including cardiovascular, stroke, cancer, neurodegenerative diseases and cataractogenesis (Halliwell and Gutteridge 1999).…”

Effect of l-ascorbic acid addition on quality, polyphenolic compounds and antioxidant capacity of cloudy apple juices

“…Clinical and epidemiological studies suggest that the consumption of 100 mg per day of vitamin C reduces the risk of heart disease and cancer [21]. Ascorbic acid is not toxic for our bodies, but taken in high doses (2-6 g per day) may cause diarrhea and disorders of the work of digestive system [22,23]. Apples are characterized by a low concentration of L-ascorbic acid, whose content varies from 3 to 30 mg per 100 g of fresh fruit and is dependent on a variety [24].…”

The efficacy of vitamin C supplementation on reducing total serum cholesterol in human subjects: a review and analysis of 51 experimental trials

“…71,72 Vitamin C has been shown to significantly reduce lipid peroxide levels 8 and protect LDL cholesterol from oxidation, thus facilitating LDL's normal binding to membrane receptors on the liver and therefore expedite its removal from the blood by LDL-cholesterol catabolic pathways. 73 However, a couple of groups contest this finding as they observed that vitamin C did not protect plasma lipids 74 or LDL 7,75 from oxidation, and one group suggested that this is because …”