The effects of vitamin B12 supplementation on metabolic profile of patients with non-alcoholic fatty liver disease: a randomized controlled trial

Talari, Hamid Reza; Molaqanbari, Mohamad Reza; Mokfi, Milad; Taghizadeh, Mohsen; Bahmani, Fereshteh; Tabatabaei, S M; Sharifi, Nasrin

doi:10.1038/s41598-022-18195-8

Cited by 16 publications

(12 citation statements)

References 44 publications

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“…Therefore, it does not necessarily imply that higher levels of serum vitamin B12 is due to a higher intake. A recent randomized controlled trial indicated that vitamin B12 supplementation significantly decreased serum levels of homocysteine compared to placebo, while no significant difference was revealed in between-group comparisons for fasting blood glucose, malondialdehyde, and liver steatosis ( 55 ). Because this study was unable to support our findings, further studies with different doses will reveal additional evidence.…”

Section: Discussionmentioning

confidence: 99%

Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data

Wang²,

Hu³

2023

Front. Nutr.

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ObjectivesMany observational studies evaluate the association between vitamin B12 and non-alcoholic fatty liver disease (NAFLD). However, the causality of this association remains uncertain, especially in European populations. We conducted a bidirectional Mendelian randomization study to explore the association between vitamin B12 and NAFLD.MethodsTwo-sample Mendelian randomization study was conducted. Summary statistics for vitamin B12 were acquired from a genome-wide association studies (GWAS) meta-analysis including 45,576 subjects. Summary-level data for NAFLD was obtained from a GWAS meta-analysis of 8,434 cases and 770,180 non-cases and another GWAS meta-analysis of 1,483 cases and 17,781 non-cases. Summary-level data for 4 enzymes including alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma glutamyltransferase (GGT), was available from the UK Biobank. Inverse variance weighting (as main analysis), weighted median estimate, robust adjusted profile score, MR-Egger, and MR-PRESSO (sensitivity analyses) were performed to calculate causal estimates.ResultsGenetically predicted higher vitamin B12 concentrations were consistently associated with an increased NAFLD in two sources. The combined odds ratio (OR) of NAFLD was 1.30 (95% confidence interval (CI), 1.13 to 1.48; p < 0.001) per SD-increase in vitamin B12 concentrations. Genetic liability to NAFLD was also positively associated with vitamin B12 concentrations (Beta 0.08, 95%CI, 0.01 to 0.16; p = 0.034). Sensitivity analyses also revealed consistent results. Genetically predicted vitamin B12 concentrations showed no significant association with liver enzymes.ConclusionThe present study indicates that increased serum vitamin B12 concentrations may play a role in NAFLD risk. NAFLD also has a causal impact on elevated vitamin B12 concentrations in the circulation. Notably, vitamin B12 concentrations imply the levels of vitamin B12 in the circulation, and higher intake of vitamin B12 may not directly lead to higher levels of serum vitamin B12, instead the higher levels of vitamin B12 in the circulation may be caused by the dysregulation of the metabolism of this vitamin in this study. There exist bidirectional causal effects between serum vitamin B12 concentrations and risk of NAFLD in European individuals.

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Section: Discussionmentioning

confidence: 99%

Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data

Wang²,

Hu³

2023

Front. Nutr.

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“…Dietary supplementation with folate and vitamin B 12 alleviates steatohepatitis by promoting the enzymatic conversion of homocysteine [180]. A randomized controlled trial also showed the beneficial effects of vitamin B 12 supplementation in patients with MAFLD [181]. However, reports about the relationship between vitamins B 5 and B 7 and MAFLD are very limited.…”

Section: Vitamin B Metabolism and Mafldmentioning

confidence: 99%

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

Fu,

Wang,

Qin

2024

Metabolites

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Metabolic-associated fatty liver disease (MAFLD), characterized primarily by hepatic steatosis, has become the most prevalent liver disease worldwide, affecting approximately two-fifths of the global population. The pathogenesis of MAFLD is extremely complex, and to date, there are no approved therapeutic drugs for clinical use. Considerable evidence indicates that various metabolic disorders play a pivotal role in the progression of MAFLD, including lipids, carbohydrates, amino acids, and micronutrients. In recent years, the medicinal properties of natural products have attracted widespread attention, and numerous studies have reported their efficacy in ameliorating metabolic disorders and subsequently alleviating MAFLD. This review aims to summarize the metabolic-associated pathological mechanisms of MAFLD, as well as the natural products that regulate metabolic pathways to alleviate MAFLD.

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“…This affects the signaling pathway in response to sterols, and as a consequence, the progression of NAFLD occurs [ 319 ]. In this way, the daily administration of 1000 µg of cyanocobalamin for 3 months in NAFLD patients decreased the serum concentration of homocysteine [ 320 ]. In NAFLD patients, by administering Vitamin B12, the serum concentration of homocysteine decreased significantly.…”

Section: Vitamins With Antioxidant Activity In Nafldmentioning

confidence: 99%

“…In NAFLD patients, by administering Vitamin B12, the serum concentration of homocysteine decreased significantly. Therefore, Vitamin B12 supplementation exerts therapeutic effects regarding the pathology of NAFLD [ 320 ]. Moreover, in NAFLD pathology, it has been observed that MDA, which is a marker of lipid peroxidation, is always increased [ 321 ].…”

Section: Vitamins With Antioxidant Activity In Nafldmentioning

confidence: 99%

The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease

Munteanu

Schwartz

2023

Antioxidants

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In the current review, we focused on identifying aliment compounds and micronutrients, as well as addressed promising bioactive nutrients that may interfere with NAFLD advance and ultimately affect this disease progress. In this regard, we targeted: 1. Potential bioactive nutrients that may interfere with NAFLD, specifically dark chocolate, cocoa butter, and peanut butter which may be involved in decreasing cholesterol concentrations. 2. The role of sweeteners used in coffee and other frequent beverages; in this sense, stevia has proven to be adequate for improving carbohydrate metabolism, liver steatosis, and liver fibrosis. 3. Additional compounds were shown to exert a beneficial action on NAFLD, namely glutathione, soy lecithin, silymarin, Aquamin, and cannabinoids which were shown to lower the serum concentration of triglycerides. 4. The effects of micronutrients, especially vitamins, on NAFLD. Even if most studies demonstrate the beneficial role of vitamins in this pathology, there are exceptions. 5. We provide information regarding the modulation of the activity of some enzymes related to NAFLD and their effect on this disease. We conclude that NAFLD can be prevented or improved by different factors through their involvement in the signaling, genetic, and biochemical pathways that underlie NAFLD. Therefore, exposing this vast knowledge to the public is particularly important.

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The effects of vitamin B12 supplementation on metabolic profile of patients with non-alcoholic fatty liver disease: a randomized controlled trial

Cited by 16 publications

References 44 publications

Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data

Bi-directional causal effect between vitamin B12 and non-alcoholic fatty liver disease: Inferring from large population data

Examining the Pathogenesis of MAFLD and the Medicinal Properties of Natural Products from a Metabolic Perspective

The Effect of Bioactive Aliment Compounds and Micronutrients on Non-Alcoholic Fatty Liver Disease

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