The Effects of Vasonatrin Peptide on Random Pattern Skin Flap Survival

Wang, Shiping; Lan, Zhiyong; Zhao, Xi; Ma, Gejia; Liu, Bei; Bao-hua, Pan; Guo, Shuzhong

doi:10.1097/sap.0b013e318255a3eb

Cited by 12 publications

(9 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Unlike these studies, we applied inactive form of PRP into dermal layer of flap tissue and showed that inactive form of PRP increased flap viability too. In this study we used random patern dorsal skin flap model 11 and we placed a silicone layer under the distal region of the flap in certain groups for inhibiting revascularization from the wound to demostrate flap viability increasing effect of inactive form of PRP is caused via revascularization from the wound bed or not. In random pattern skin flap models as we used, 52% part of the flap stays viable with basal vascularization as with composite graft 12 so revascularization from the wound bed is very important for flap viability.…”

Section: ■ Discussionmentioning

confidence: 99%

“…Surgical area was cleaned with 10% povidone iodine solution and covered under sterilized conditions. From their back, random patern dorsal flap included panniculus carnosus of 9 x 3 cm in size was elevated 11 . 3x4.5 cm silicone layer was placed under the distal region of the flap in 18 animals that were determined randomly for precluding vascularization from the wound bed.…”

Section: Surgical Proceduresmentioning

confidence: 99%

See 1 more Smart Citation

The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

et al. 2017

View full text Add to dashboard Cite

Purpose: To evaluate the effect of inactive form of platelet rich plasma (PRP) on the flap viability. Methods: Thirty six rats were used. Rats were divided into six groups then 9x3 cm random pattern skin flaps were elevated from dorsum of all rats. For precluding vascularization from the base, a silicone layer was placed under the flap in groups 2(only flap+silicone), 4(saline+silicone) and 6(PRP+silicone). In groups 1(only flap), 2(only flap+silicone) nothing was done except flap surgery. In groups 3(saline) and 4(saline+silicone), saline was applied intradermally , in groups 5(PRP) and 6(PRP+silicone), inactive form of PRP which obtained from different 16 rats was applied intradermally, into certain points of flaps immediately after surgery. After 7 days flap necrosis ratio was measured in all groups. Results: Mean necrosis rate in group 5(PRP) (16.05%) was statistically significantly lower than group 1(only flap) (31,93%) and group 3(saline) (30,43%) (p<0.001). Mean necrosis rate in group 6(PRP+silicone) (36.37%) was statistically significantly lower than group 2(only flap+silicone) (47.93%) and group 4(saline+silicone) (45.65%) (p<0.001). Conclusion: Intradermal inactive platelet rich plasma administration decreases flap necrosis so for skin application.

show abstract

Section: ■ Discussionmentioning

confidence: 99%

Section: Surgical Proceduresmentioning

confidence: 99%

The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Many agents that enhance or reduce flap viability have been reported in the literature. Investigated agents improving flap viability include agents suppressing free radical production (6,7), nitric oxide (8,9), sildenafil (10,11), vascular endothelial growth factor (12) and vasonatrin peptide (13).…”

mentioning

confidence: 99%

Prevention of unfavourable effects of cigarette smoke on flap viability using botulinum toxin in random pattern flaps: An experimental study

Karayel¹,

Kaya²,

Çaydere³

et al. 2015

CAN J PLAST SURG

View full text Add to dashboard Cite

“…From the back of the rats, a 9×3 cm random-pattern skin flap with the panniculus carnosus was elevated. The flaps were then sutured to the same area with 4/0 Vicryl (8).…”

Section: Surgicalmethodsmentioning

confidence: 99%

The Effect of <i>Quercus coccifera L.</i> Extract on the Necrosis of Random-pattern Skin Flaps in Rats

Orhan¹,

Aka²,

Yuzbasioglu³

et al. 2019

Haseki

View full text Add to dashboard Cite

İskemi-reperfüzyon hasarı önemli bir flep kaybı nedenidir. Bu çalışmada antioksidan ve antiinflamatuvar aktivitesi olduğu bilinen Quercus coccifera ekstresinin flep yaşayabilirliği üzerindeki etkisi incelenmiştir Yöntemler: On sekiz Wistar cinsi sıçan kullanıldı. Sıçanların sırt bölgesinde 9x3 cm'lik random patern deri flebi kaldırıldı ve daha sonra flep tekrar aynı yere iade edildi. Daha sonra ratlar üç gruba ayrıldı. Grup 2'deki sıçanların sırtlarına günde bir defa 2 cc nitrofurazon krem, grup 3'teki sıçanların sırtına ise günde bir defa 2 cc Q. coccifera ektresi uygulandı. Grup 1'deki sıçanlara flep cerrahisi dışında bir işlem yapılmadı. Flep cerrahisinden 7 gün sonra fleplerdeki nekroz miktarı hesaplandı ve doku örnekleri alınarak histopatolojik inceleme yapıldı Bulgular: Grup 1'de ortalama nekroz miktarı %44,1, grup 2'de %42,5 ve grup 3'de %21,8 olarak hesaplandı. Grup 3'deki nekroz miktarı, grup 1 ve grup 2'den istatistiksel olarak anlamlı olacak şekilde az olduğu tespit edildi (p<0,001, p<0,001). Nötrofil skoru da grup 3 'de, grup 1 ve grup 2'ye göre istatistiksel olarak anlamlı olacak şekilde az bulundu. (p=0,002 ve p=0,002) Sonuç: Q. coccifera ekstresi uygulanması ile fleplerdeki nekroz miktarı azalmaktadır.

show abstract

The Effects of Vasonatrin Peptide on Random Pattern Skin Flap Survival

Abstract: This study found that VNP, which could elevate the tissue blood perfusion and mitigate the tissue damage and inflammatory reaction, is associated with a higher percentage of survival random pattern skin flap area.

Cited by 12 publications

References 23 publications

The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

The effect of intradermal administration of inactive platelet-rich plasma on flap viability in rats

Prevention of unfavourable effects of cigarette smoke on flap viability using botulinum toxin in random pattern flaps: An experimental study

The Effect of <i>Quercus coccifera L.</i> Extract on the Necrosis of Random-pattern Skin Flaps in Rats

Contact Info

Product

Resources

About