2014
DOI: 10.1097/sap.0b013e318255a3eb
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The Effects of Vasonatrin Peptide on Random Pattern Skin Flap Survival

Abstract: This study found that VNP, which could elevate the tissue blood perfusion and mitigate the tissue damage and inflammatory reaction, is associated with a higher percentage of survival random pattern skin flap area.

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Cited by 12 publications
(9 citation statements)
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“…Unlike these studies, we applied inactive form of PRP into dermal layer of flap tissue and showed that inactive form of PRP increased flap viability too. In this study we used random patern dorsal skin flap model 11 and we placed a silicone layer under the distal region of the flap in certain groups for inhibiting revascularization from the wound to demostrate flap viability increasing effect of inactive form of PRP is caused via revascularization from the wound bed or not. In random pattern skin flap models as we used, 52% part of the flap stays viable with basal vascularization as with composite graft 12 so revascularization from the wound bed is very important for flap viability.…”
Section: ■ Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Unlike these studies, we applied inactive form of PRP into dermal layer of flap tissue and showed that inactive form of PRP increased flap viability too. In this study we used random patern dorsal skin flap model 11 and we placed a silicone layer under the distal region of the flap in certain groups for inhibiting revascularization from the wound to demostrate flap viability increasing effect of inactive form of PRP is caused via revascularization from the wound bed or not. In random pattern skin flap models as we used, 52% part of the flap stays viable with basal vascularization as with composite graft 12 so revascularization from the wound bed is very important for flap viability.…”
Section: ■ Discussionmentioning
confidence: 99%
“…Surgical area was cleaned with 10% povidone iodine solution and covered under sterilized conditions. From their back, random patern dorsal flap included panniculus carnosus of 9 x 3 cm in size was elevated 11 . 3x4.5 cm silicone layer was placed under the distal region of the flap in 18 animals that were determined randomly for precluding vascularization from the wound bed.…”
Section: Surgical Proceduresmentioning
confidence: 99%
“…Many agents that enhance or reduce flap viability have been reported in the literature. Investigated agents improving flap viability include agents suppressing free radical production (6,7), nitric oxide (8,9), sildenafil (10,11), vascular endothelial growth factor (12) and vasonatrin peptide (13).…”
mentioning
confidence: 99%
“…From the back of the rats, a 9×3 cm random-pattern skin flap with the panniculus carnosus was elevated. The flaps were then sutured to the same area with 4/0 Vicryl (8).…”
Section: Surgicalmethodsmentioning
confidence: 99%