The Effects of Vaginal Prolapse Surgery Using Synthetic Mesh on Vaginal Wall Sensibility, Vaginal Vasocongestion, and Sexual Function: A Prospective Single‐Center Study

Weber, Maaike A.; Lakeman, M. M. E.; Laan, Ellen; Roovers, Jan‐Paul W. R.

doi:10.1111/jsm.12545

Cited by 10 publications

(6 citation statements)

References 28 publications

(46 reference statements)

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“…Pelvic organ prolapse (POP) is a common condition resulting from damage to the supportive structures of the pelvic floor. 1,2 The annual incidence of surgery for POP is approximately 4.9 cases per 1000 women, with an overall lifetime risk for surgery of 11%. 3,4 Synthetic permanent polypropylene (PP) meshes have been introduced for the surgical repair of POP to provide mechanical support to the pelvic floor by inducing a foreign body response.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the short‐term host response and biomechanics of an absorbable poly‐4‐hydroxybutyrate scaffold in a sheep model following vaginal implantation

Diedrich

Guler

Hympánová

et al. 2021

BJOG

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Section: Introductionmentioning

confidence: 99%

Evaluation of the short‐term host response and biomechanics of an absorbable poly‐4‐hydroxybutyrate scaffold in a sheep model following vaginal implantation

Diedrich

Guler

Hympánová

et al. 2021

BJOG

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“…Native tissue prolapse repair has been shown to have a higher anatomical failure rate, which has led to the adoption of alternative techniques, in particular, the use of augmented repair with mesh and an abdominal approach to mesh placement. Some surgeons favor transvaginal mesh in selected patients as randomized trials show a significantly lower rate of prolapse recurrence compared with native tissue repair [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Analysis of changes in sexual function in women undergoing pelvic organ prolapse repair with abdominal or vaginal approaches

et al. 2016

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“…Pelvic organ prolapse (POP) is a common condition resulting from damage to the supportive structures of the pelvic floor (1,2). The annual incidence of surgery for POP is approximately 4.9 cases per 1000 women with the overall life-time risk for POP surgery of 11% (3,4).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Short Term Host Response and Biomechanics of an Absorbable Poly-4-Hydroxybutyrate Scaffold in a Sheep Model Following Vaginal Implantation

Diedrich¹,

Güler²,

Lh³

et al. 2021

Preprint

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Objective: To compare the host and biomechanical response to a fully absorbable poly-4-hydroxybutyrate (P4HB) scaffold to the response to PP mesh in an animal model of vaginal POP surgery. Design: A study employing a sheep model Setting: KU Leuven Center for Surgical Technologies Population: 14 parous female Mule sheep Methods: P4HB scaffolds were surgically implanted in the posterior vaginal wall of sheep. The comparative PP mesh data were obtained from an identical protocol. Main outcome measures: Gross necropsy, histological and biomechanical evaluation of explants, and the in vivo P4HB scaffold degradation were evaluated at 60- and 180-days post-implantation. Results: Gross necropsy revealed no implant related adverse events using P4HB scaffolds. The tensile stiffness of the P4HB explants increased at 180-days (12.498 ± 2.66 N/mm (P=0.019)) as compared to 60-days (4.585 ± 1.57 N/mm) post-implantation, while P4HB degraded gradually. P4HB scaffolds exhibited excellent tissue integration with dense connective tissue and a moderate initial host response. P4HB scaffolds induced a significantly higher M2/M1 ratio (1.70 ± 0.67 SD, score 0-4), as compared to PP mesh (0.99 ± 0.78 SEM, score 0-4) at 180-days. Conclusions: P4HB scaffold facilitated a gradual load transfer to vaginal tissue over time. The fully absorbable P4HB scaffold, in comparison to PP mesh, has a favorable host response with comparable load bearing capacity. If these results are also observed at longer follow-up, a clinical study for vaginal POP surgery may be warranted to demonstrate efficacy. Key words: Pelvic organ prolapse, vaginal surgery, Poly-4-hydroxybutyrate, degradable scaffold, host response, biomechanics.

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The Effects of Vaginal Prolapse Surgery Using Synthetic Mesh on Vaginal Wall Sensibility, Vaginal Vasocongestion, and Sexual Function: A Prospective Single‐Center Study

Cited by 10 publications

References 28 publications

Evaluation of the short‐term host response and biomechanics of an absorbable poly‐4‐hydroxybutyrate scaffold in a sheep model following vaginal implantation

Evaluation of the short‐term host response and biomechanics of an absorbable poly‐4‐hydroxybutyrate scaffold in a sheep model following vaginal implantation

Analysis of changes in sexual function in women undergoing pelvic organ prolapse repair with abdominal or vaginal approaches

Evaluation of the Short Term Host Response and Biomechanics of an Absorbable Poly-4-Hydroxybutyrate Scaffold in a Sheep Model Following Vaginal Implantation

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