The effects of using pregabalin versus clonidine premedication in laparoscopic cholecystectomy

Bahgat, Nadia M.; Sadik, Sadik A; Mahdy, Wafiya R; El-Sharkawy, Osama A; Metwally, Ahmed A.; El-Shafey, Maather K

doi:10.4103/1110-2098.198695

Cited by 3 publications

(3 citation statements)

References 3 publications

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“…There was a non-significant difference between groups II and III in intraoperative fentanyl consumption but, there was a moderately significant reduction in groups II and III compared with group I. These results are in agreement with those of Bahgat et al, whose study showed that the preoperative administration of 300 mg of oral pregabalin significantly reduces the intraoperative fentanyl requirements and end-tidal isoflurane concentrations required to maintain adequate anesthesia [22].…”

Section: Discussionsupporting

confidence: 90%

Preoperative Sedation, Hemodynamic Stability during General Anesthesia and Improving Postoperative Pain: Pregabalin Is the Answer

El-Hussiny¹,

Fahmy²,

Eldemrdash³

2018

OJAnes

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Background: Tracheal intubation is a noxious stimulus that tends to provoke a marked sympathetic response which is potentially deleterious in some patients. Various methods have been used to minimize and attenuate these potentially harmful responses. Aim of the study: The present study compared the efficacy and safety of two different doses (150 mg and 300 mg) of oral pregabalin premedication on attenuation of the hemodynamic pressor response to airway instrumentation, perioperative hemodynamic stability, preoperative sedation, and postoperative pain reduction. Patients and methods: This prospective, observational study consisted of 60 adult patients scheduled for laparoscopic cholecystectomy. The patients were randomized into three groups of 20 patients each. Group I (P0) received an oral placebo, group II (P150) received 150 mg of oral pregabalin and group III (P300) received 300 mg of oral pregabalin 1 h prior to induction. All patients were assessed for pre-operative sedation, perioperative hemodynamic changes, Post-operative pain and analgesic consumption. Results: Regarding the efficacy of the preoperative administration of oral pregabalin, a dose dependent attenuation in the increased in heart rate, systolic, and diastolic blood pressure, and mean arterial blood pressure resulting from laryngoscopy and intubation was observed (300 mg > 150 mg), along with a subsequent decrease in intraoperative fentanyl supplementation. On anxiolysis, patients were more comfortable and asleep in the pregabalin groups as compared with the control group, in which more patients were awake and agitated. Post-operative pain and analgesic consumption were effectively reduced by (150 mg and 300 mg) pregabalin in a dose-dependent manner. Postoperative nausea and vomiting were significantly lower with the administration of pregabalin compared with the placebo group (P < 0.008). Additionally, pregabalin increased the incidence of dizziness and visual disturbances in a dose-dependent manner. Con- clusion: Oral pregabalin premedication adequately sedated patients and attenuated the hemodynamic pressor response to airway instrumentation in a dose-dependent manner. Premedicated patients were haemodynamically stable perioperatively without recovery time prolongation or side effects, except dizziness with 300 mg of oral pregabalin. Additionally, oral pregabalin reduced postoperative pain and analgesic consumption in a dose-dependent manner.

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Section: Discussionsupporting

confidence: 90%

Preoperative Sedation, Hemodynamic Stability during General Anesthesia and Improving Postoperative Pain: Pregabalin Is the Answer

El-Hussiny¹,

Fahmy²,

Eldemrdash³

2018

OJAnes

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“…Various study done by Kumkum Gupta et al (2011), [8] aged 35 to 52 years, Shirin Parveen et al (2016), [9] included aged between 20-60 years of both sexes, Bhawna Rastogi et al (2012), [10] aged 24-56 years. Another study done by Nadia M Bahgat et al (2016), [11] aged 18-60 years. No significant difference was found in age, sex in our study.…”

Section: Discussionmentioning

confidence: 98%

Oral Pregabalin vs Oral Hormone in An Exceedingly Attenuation of Hemodyanamic Response to Laryngoscopy Insertion, Extubation in Patients Undergoing Laparoscopic Cholecystectomy

Mishra

Gupta

2019

AAN

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Background: Premedication in the form of vasodilators, adreno receptor blockers, calcium channel blockers and opioids were used earlier to attenuate these responses, with variable results. This study will be conducted to evaluate & compare efficacy of oral pregabalin & oral melatonin in attenuation of haemodynamic responses during laryngoscopy, intubation & extubation in laparoscopic cholecystectomy. Subjects and Methods: This is a Prospective randomized double blind comparative study done on 60 Patients undergoing laparoscopic

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“…The use of pregabalin in combination with other non-opioid regimens as part of multimodal analgesia can provide significant pain relief and decrease postoperative pain scores. This leads to a decrease in the duration of hospital stay and reduces complications such as thromboembolism caused by immobility [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Reduction of Acute Postoperative Pain With Pre-Emptive Pregabalin Following Laparoscopic Cholecystectomy

Najam¹,

Jafri²,

Khan³

et al. 2022

Cureus

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Pregabalin has been considered to be a safe treatment for neuropathic pain. Owing to the lack of research regarding the use of pregabalin in the management of pain in under-resourced settings, our study aimed to deduce the effectiveness of a pre-emptive single dose of pregabalin pre-operatively to provide pain relief after laparoscopic cholecystectomy. Treating acute pain is essential to avoid an increased hospital stay. There is a need for non-opioid drugs with lower risks to avoid using opioids, which lead to many side effects. MethodologyPatients diagnosed with cholelithiasis and scheduled to undergo laparoscopic cholecystectomy at the Abbasi Shaheed Hospital were included in this study. The study aimed to determine whether the effect of pregabalin in combination with patient-controlled analgesia can decrease pain scores. This was a double-blind study where patients, caregivers, and analysts were blinded to group allocation and drugs administered until the data was recorded and sealed. The patients were divided into pregabalin and placebo groups through a webbased model; blocks of four were used and stratification was employed at the center. A confidence interval of 95% was considered significant. ResultsIn our study, a total number of 60 patients were included. They were randomly divided by a computer-based model into two groups, the pregabalin group, and the control group. The placebo group had 33 patients while the pregabalin group had 27 patients. The pregabalin group was given a pregabalin tablet of 150 mg before surgery while the placebo group was given an identical-looking placebo. Patient-controlled analgesia was started in both groups and the visual analog scale (VAS) scoring was observed postoperatively. The pregabalin group had a decreased incidence of pain as compared to the placebo group. There were no significant side effects during the trial; episodes of vomiting were managed using intravenous ondansetron. ConclusionPregabalin is effective in reducing pain in an acute postoperative period when compared with a placebo. Patients who were pre-emptively administered pregabalin reported decreased VAS as compared to the placebo. However, both were inefficient in reducing postoperative nausea and vomiting.

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The effects of using pregabalin versus clonidine premedication in laparoscopic cholecystectomy

Cited by 3 publications

References 3 publications

Preoperative Sedation, Hemodynamic Stability during General Anesthesia and Improving Postoperative Pain: Pregabalin Is the Answer

Preoperative Sedation, Hemodynamic Stability during General Anesthesia and Improving Postoperative Pain: Pregabalin Is the Answer

Oral Pregabalin vs Oral Hormone in An Exceedingly Attenuation of Hemodyanamic Response to Laryngoscopy Insertion, Extubation in Patients Undergoing Laparoscopic Cholecystectomy

Reduction of Acute Postoperative Pain With Pre-Emptive Pregabalin Following Laparoscopic Cholecystectomy

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