The effects of urolithin A on poly I:C-induced microglial activation
Yakum Benard Mingo,
Lea Gabele,
Niklas Lonnemann
et al.
Abstract:Neuroinflammation can be triggered by various stimuli, including viral infections. Viruses can directly invade the brain and infect neuronal cells or indirectly trigger a “cytokine storm” in the periphery that eventually leads to microglial activation in the brain. While this initial activation of microglial cells is important for viral clearance, chronic activation leads to excessive inflammation and oxidative stress, which can be neurotoxic. Remarkebly, recent studies have shown that certain viruses such as … Show more
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